The Emerging Role of Quercetin in the Treatment of Chronic Pain

Liu, Cheng; Liu, Dai-Qiang; Tian, Yuan; Mei, Wei; Tian, Xiaojing; Xu, Aijun; Zhou, Ya‐Qun

doi:10.2174/1570159x20666220812122437

Cited by 9 publications

(4 citation statements)

References 73 publications

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“…Another constituent, quercetin, present in CT, CF, and GR, is a flavonoid with reported analgesic, anti-inflammatory, and antioxidant effects [ 32 ]. Additionally, PR contains paeoniflorin and GR contains glycyrrhizin, which both impact pain and inflammation [ 31 , 33 - 35 ]. For this study, the literature corroborated the analgesic and anti-inflammatory effects of these five principal compounds in NPP constituent herbs, guiding the subsequent HPLC analysis to confirm their presence.…”

Section: Discussionmentioning

confidence: 99%

Toxicity Evaluation of a Non-Pain Pharmacopuncture Extract Using a Bacterial Reverse Mutation Test

Hwang,

Jung

2024

J Pharmacopuncture

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Section: Discussionmentioning

confidence: 99%

Toxicity Evaluation of a Non-Pain Pharmacopuncture Extract Using a Bacterial Reverse Mutation Test

Hwang,

Jung

2024

J Pharmacopuncture

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“…Flavonoids have been widely used for their analgesic efect due to their antiinfammatory and antioxidant abilities. For example, quercetin modulated the MAPK, NF-κB, and NLRP3 to alleviate the infammatory pain, neuropathic pain, and cancer pain [82]. Orientin can modulate the MAPK and NF-κB [24], therefore it can be used for other chronic pain treatments in pediatric patients.…”

Section: Discussionmentioning

confidence: 99%

Orientin Reduces the Effects of Repeated Procedural Neonatal Pain in Adulthood: Network Pharmacology Analysis, Molecular Docking Analysis, and Experimental Validation

Guo,

Huang,

Liu

et al. 2023

Pain Research and Management

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Background. Premature infants often undergo painful procedures and consequently experience repeated procedural neonatal pain. This can elicit hyperalgesia and cognitive impairment in adulthood. Treatments for neonatal pain are limited. Orientin is a flavonoid C-glycoside that has repeatedly been shown to have pharmacological effects in the past decades. The aim of this study was to systematically explore the effect of orientin on repeated procedural neonatal pain using network pharmacology, molecular docking analysis, and experimental validation. Methods. Several compound-protein databases and disease-protein databases were employed to identify proteins that were both predicted targets of orientin and involved in neonatal pain. A protein-protein interaction (PPI) network was constructed, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to explore the potential mechanism of action. Molecular docking analysis was employed to calculate the binding energy and visualize the interactions between orientin and potential target proteins. Finally, a mouse model of repeated procedural neonatal pain was established and orientin was administered for 6 days. The mechanical and thermal pain thresholds were assessed in neonates and adult mice. A Morris water maze was employed to investigate cognitive impairment in adult mice. Results. A total of 286 proteins that were both predicted targets of orientin and involved in neonatal pain were identified. The hub proteins were SRC, HSP90AA1, MAPK1, RHOA, EGFR, AKT1, PTPN11, ESR1, RXRA, and HRAS. GO analysis indicated that the primary biological process (BP), molecular function (MF), and cellular component (CC) were protein phosphorylation, protein kinase activity, and vesicle lumen, respectively. KEGG analysis revealed that the mitogen-activated protein kinase (MAPK) signaling pathway may be the key to the mechanism of action. Molecular docking analysis showed the high binding affinities of orientin for MAPK1, MAPK8, and MAPK14. In mice, orientin inhibited the hyperalgesia in the pain threshold tests in neonates and adult mice and cognitive impairment in adult mice. Immunofluorescence showed that phosphorylated MAPK1 (p-ERK) protein levels in the hippocampus and spinal dorsal horn were downregulated by orientin. Conclusion. The findings suggested that orientin alleviates neonatal pain, and the MAPK signaling pathway is involved.

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“…-isopropil-2-metil-2-ciclo-hexen-1-ona (1) e 1-metil-4β-isopropil-1-ciclohexeno-4α, 5α, 6αtriol (2), juntamente com cinco compostos conhecidos, (1S, 2S, 3R, 4S) -1-metil-4-(propan-2il) ciclo-hexano-1,2,3,4-tetrol (3), (1R, 2S, 3S, 4S) -1,2,3,4-tetra-hidroxi-p-mentano (4), (1R, 2S ) -3-p-menten-1,2-diol ( 5), (1R, 4S) -p-ment-2-en1-ol (6) e 1,4-di-hidroxi-p-menth-2-ene (7) (Hou et al, 2017). Também foram isolados da planta vários alcaloides (Shoaib et al, 2016), flavonoides como quercetina, luteolina, e outros compostos com atividade antinociceptiva comprovada cientificamente (Liu et al, 2022, Ntalouka , Tsirivakou, 2023, Estudos fitoquímicos com C. retusum estão sendo conduzidos por Farias (resultados não publicados) e evidenciaram 65% de semelhança fitoquímica com C. ambrosioides. Ao que tudo indica, a semelhança entre as duas plantas quanto as suas respectivas propriedades farmacológicas pode ser devido aos fitoconstituintes que ambas as espécies possuem em comum.…”

Section: Efeito Do Ehcr Sobre a Nocicepção Induzida Pelo Calor: Teste...unclassified

Avaliação pré-clínica do extrato hidroalcoólico de Chenopodium retusum: ênfase ao efeito antinociceptivo

Dadam Junior,

Pavesi,

De Bortoli

et al. 2023

Braz. J. Hea. Rev.

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A planta Chenopodium retusum é uma importante espécie do gênero Chenopodium, o qual contém espécies com propriedade analgésica, usada popularmente no tratamento de distúrbios gastrointestinais e manejo da dor. Este estudo objetivou avaliar o efeito antinociceptivo do extrato hidroalcoólico de Chenopodium retusum (EHCR) em testes farmacológicos de dor aguda in vivo e testes comportamentais (Campo aberto/TCA). Camundongos Swiss fêmeas (25-30g/n=8) foram submetidos a testes farmacológicos de dor aguda induzida quimicamente por: formalina (2,5%), ácido acético (0,6%), capsaicina (1,6 µg/pata), glutamato (30 nmol/pata) e termicamente (placa quente). EHCR (50, 150 e 300 mg/kg) foi administrado por via intraperitoneal ou oral respectivamente 30 e 60 minutos antes dos testes. Controles positivos Indometacina (10 mg/kg) e/ou Morfina (5 mg/kg) e, negativo (veículo de solubilização do EHCR) foram utilizados nos experimentos. EHCR reduziu ambas as fases (neurogênica e inflamatória) da nocicepção induzida pela formalina, e apresentou efeito antiedematogênico. Foi também observada redução da nocicepção induzida pela capsaicina, glutamato e ácido acético. No teste da placa quente houve aumento do limiar nociceptivo. Os resultados em conjunto confirmam o efeito antinociceptivo do EHCR, validando em parte o uso de Chenopodium retusum no manejo da dor. Estudos futuros poderão determinar os fitoconstituintes envolvidos e os mecanismos farmacodinâmicos responsáveis por essa ação.

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The Emerging Role of Quercetin in the Treatment of Chronic Pain

Cited by 9 publications

References 73 publications

Toxicity Evaluation of a Non-Pain Pharmacopuncture Extract Using a Bacterial Reverse Mutation Test

Toxicity Evaluation of a Non-Pain Pharmacopuncture Extract Using a Bacterial Reverse Mutation Test

Orientin Reduces the Effects of Repeated Procedural Neonatal Pain in Adulthood: Network Pharmacology Analysis, Molecular Docking Analysis, and Experimental Validation

Avaliação pré-clínica do extrato hidroalcoólico de Chenopodium retusum: ênfase ao efeito antinociceptivo

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