The emerging role of noncoding RNAs in neuroinflammation: Implications in pathogenesis and therapeutic approaches

Ebrahimi, Reyhane; Golestani, Abolfazl

doi:10.1002/jcp.30624

Cited by 7 publications

(4 citation statements)

References 115 publications

(177 reference statements)

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“…RNA-based medications can include stabilized miRNAs, anti-miRNA (AM, antagomir) and other approaches directed against specific miRNA activators such as NF-kB (p50/p65), using targeted anti-NF-kB (p50/p65) treatment strategies, or any combination of these advanced therapeutics. NV, EX and/or EMV packets containing strategically designed and stabilized miRNA, anti-miRNA (AM), mRNA in conjunction with other therapeutic components and inflammatory mediators and tailored to individual AD patients using precision medicine and predictive, participatory, preventive and personalized (P4) approaches should be useful in the clinical management of AD and other complex neurological disorders that are now urgently requiring effective disease-modifying intervention [ 17 , 35 , 53 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 75 , 79 , 80 , 81 , 82 , 100 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 ].…”

Section: Discussionmentioning

confidence: 99%

“…The intrinsic complexity and magnitude of gene expression in the human brain and CNS make the elucidation of even fundamental miRNA-mRNA signaling pathways exceptionally challenging, as does the search for reliable biomarkers for neurodegeneration in the periphery. The manipulation of gene expression using miRNA-based strategies and the use of extracellular vesicles for therapeutic delivery should be of great strategic value in the clinical management of AD and related forms of progressive age-related inflammatory neurodegeneration [ 31 , 35 , 50 , 51 , 80 , 81 , 82 , 83 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 ].…”

Section: Specific Features Of Mirna Abundance Speciation and Traffick...mentioning

confidence: 99%

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MicroRNA (miRNA) Complexity in Alzheimer’s Disease (AD)

Lukiw

2023

Biology

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AD is a complex, progressive, age-related neurodegenerative disorder representing the most common cause of senile dementia and neurological dysfunction in our elderly domestic population. The widely observed heterogeneity of AD is a reflection of the complexity of the AD process itself and the altered molecular-genetic mechanisms operating in the diseased human brain and CNS. One of the key players in this complex regulation of gene expression in human pathological neurobiology are microRNAs (miRNAs) that, through their actions, shape the transcriptome of brain cells that normally associate with very high rates of genetic activity, gene transcription and messenger RNA (mRNA) generation. The analysis of miRNA populations and the characterization of their abundance, speciation and complexity can further provide valuable clues to our molecular-genetic understanding of the AD process, especially in the sporadic forms of this common brain disorder. Current in-depth analyses of high-quality AD and age- and gender-matched control brain tissues are providing pathophysiological miRNA-based signatures of AD that can serve as a basis for expanding our mechanistic understanding of this disorder and the future design of miRNA- and related RNA-based therapeutics. This focused review will consolidate the findings from multiple laboratories as to which are the most abundant miRNA species, both free and exosome-bound in the human brain and CNS, which miRNA species appear to be the most prominently affected by the AD process and review recent developments and advancements in our understanding of the complexity of miRNA signaling in the hippocampal CA1 region of AD-affected brains.

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Section: Discussionmentioning

confidence: 99%

Section: Specific Features Of Mirna Abundance Speciation and Traffick...mentioning

confidence: 99%

MicroRNA (miRNA) Complexity in Alzheimer’s Disease (AD)

Lukiw

2023

Biology

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“…They proposed that miR146a acts as a negative feedback modulator to regulate the synthesis of these inflammatory cytokines. 38 …”

Section: Discussionmentioning

confidence: 99%

Evaluation of MicroRNAs in Pediatric Epilepsy

Çarman¹,

Tekin²,

Çavuşoğlu³

et al. 2023

Turkish Archives of Pediatrics

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Objective: The pathophysiology of epilepsy remains unknown. Recent research has shown that microRNA expression changes in epileptic adults. In the present work, we aimed to identify serum microRNA expression in drug-responsive and resistant children with idiopathic generalized epilepsy. Materials and Methods: The study included 43 (20 male and 23 female) epilepsy patients and 66 (43 male and 23 female) control subjects. The mean ages of the groups were 113.41 ± 61.83 and 105.46 ± 62.31 months, respectively. Twenty-eight epileptic patients were classified as drug resistant. Thirteen of the controls were the siblings of patients with epilepsy. The study only included children with idiopathic generalized epilepsy who had normal brain magnetic resonance imaging. The serum microRNA expressions (microRNA-181a, microRNA-155, microRNA-146, and microRNA-223) were investigated. Expressions of serum microRNA-181a, microRNA-155, microRNA-146, and microRNA-223 were previously investigated in epilepsy patients and children with febrile seizures. Therefore, these microRNAs were chosen. The expressions of serum levels of microRNAs were determined using quantitative real-time polymerase chain reaction. Results: The results indicated that the expressions of serum microRNA-155 and microRNA-223 were elevated in epileptic children ( P < .05). The expression of the same microRNAs was also elevated in individuals with drug-resistant epilepsy compared to healthy controls ( P < .05). microRNA-146a, microRNA-155, and microRNA-223 expressions were higher in drug-resistant patients than in drug-responsive children ( P < .05). A logistic regression study determined that an increase of microRNA-155 was a risk for epilepsy, while a decrease of microRNA-146a risk for epilepsy. Conclusion: Few researchers have investigated the function of microRNAs in the development of childhood epilepsy. Our findings revealed that epilepsy patients have abnormal microRNAexpression.

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“…Hu et al, 2013; Tehrani et al, 2021). Overall, it is tempting to speculate that changes in the ncRNAs expression levels may interact with abnormalities in the insulin signaling pathway and together affect the pathophysiological mechanisms underlying AD (Ebrahimi & Golestani, 2022). Hence, here, we aimed to review the recent studies about the role of ncRNAs and the downstream target proteins in the insulin signaling pathway that may play an important role in AD pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

A novel approach to type 3 diabetes mechanism: The interplay between noncoding RNAs and insulin signaling pathway in Alzheimer's disease

Moayedi

Orandi

Ebrahimi

et al. 2022

Journal Cellular Physiology

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Today, growing evidence indicates that patients with type 2 diabetes (T2D) are at a higher risk of developing Alzheimer's disease (AD). Indeed, AD as one of the main causes of dementia in people aged more than 65 years can be aggravated by insulin resistance (IR) and other metabolic risk factors related to T2D which are also linked to the function of the brain. Remarkably, a new term called “type 3 diabetes” has been suggested for those people who are diagnosed with AD while also showing the symptoms of IR and T2D. In this regard, the role of genetic and epigenetic changes associated with AD has been confirmed by many studies. On the other hand, it should be noted that the insulin signaling pathway is highly regulated by various mechanisms, including epigenetic factors. Among these, the role of noncoding RNAs (ncRNAs), including microRNAs and long noncoding RNAs has been comprehensively studied with respect to the pathology of AD and the most well‐known underlying mechanisms. Nevertheless, the number of studies exploring the association between ncRNAs and the downstream targets of the insulin signaling pathway in the development of AD has notably increased in recent years. With this in view, the present study aimed to review the interplay between different ncRNAs and the insulin signaling pathway targets in the pathogenesis of AD to find a new approach in the field of combining biomarkers or therapeutic targets for this disease.

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The emerging role of noncoding RNAs in neuroinflammation: Implications in pathogenesis and therapeutic approaches

Cited by 7 publications

References 115 publications

MicroRNA (miRNA) Complexity in Alzheimer’s Disease (AD)

MicroRNA (miRNA) Complexity in Alzheimer’s Disease (AD)

Evaluation of MicroRNAs in Pediatric Epilepsy

A novel approach to type 3 diabetes mechanism: The interplay between noncoding RNAs and insulin signaling pathway in Alzheimer's disease

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