The emerging role of miR-20b in human cancer and other disorders: Pathophysiology and therapeutic implications

Abstract

miR-20b is a microRNA with diverse and somehow contradictory roles in the pathogenesis of human disorders, especially cancers. It has been known to be a tumor suppressor in colon cancer, renal cell carcinoma, prostate cancer, osteosarcoma and papillary thyroid cancer. In lung cancer and breast cancers, both tumor suppressor and oncogenic effects have been identified for this miRNA. Finally, in T cell leukemia, hepatocellular carcinoma, esophageal squamous cell carcinoma and cervical and gastric cancers, miR-20b is regarded as an oncogenic miRNA. In several types of cancer, dysregulation of miR-20b has been recognized as a predictive marker for patients’ survival. Dysregulation of miR-20b has also been recognized in Alzheimer’s disease, diabetic retinopathy, myocardial ischemia/infarction, chronic hepatitis B and multiple sclerosis. In the current review, we have summarized the miR-20b targets and related cellular processes. We have also provided a review of participation of this miRNA in different human disorders.

Alterations of miRNA Expression in Diffuse Hyperplastic Perilobar Nephroblastomatosis: Mapping the Way to Understanding Wilms’ Tumor Development and Differential Diagnosis

“…Both arms of the precursor mir-20b, miR-20b-5p and miR-20b-3p, are involved in the pathogenesis of various malignant and non-malignant conditions, with both tumor suppressor and oncogenic roles reported in the literature [38]. In our study, interesting log 2 FC values were obtained for miR-20b-5p.…”

MicroRNA Expression Profiling—Potential Molecular Discrimination of Papillary Thyroid Carcinoma Subtypes

“…Further research is needed to elucidate the specific roles of these miRNAs and their potential as therapeutic targets in TC treatment. Studies suggest that miR-20b dysregulation may play a role in TC progression by influencing key signalling pathways [26,27], including MAPK, as shown by the Diana miRpath analysis of this study, revealing 27 genes targeted by this transcript. miR-20b involvement in PTC is due to its regulatory impact on the MAPK signalling pathway [28] underscores its significance in the molecular landscape of PTC and its importance in differential diagnosis of TC subtypes.…”