The Emerging Role of Long Non-Coding RNAs in Plant Defense Against Fungal Stress

Zhang, Hong; Guo, Huan; Hu, Weiguo; Ji, Wanquan

doi:10.3390/ijms21082659

Cited by 30 publications

(14 citation statements)

References 99 publications

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“…The first eukaryotic lncRNA was H19, identified in the mouse [ 10 ]. GmENOD90 from Glycine max was the first identified plant lncRNA using RNA sequencing and in vitro based analysis [ 11 ]. Due to high-resolution transcriptomic analysis, the identification of lncRNAs in plants has blossomed and caught up with the mammalian research field in a few years [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…GmENOD90 from Glycine max was the first identified plant lncRNA using RNA sequencing and in vitro based analysis [ 11 ]. Due to high-resolution transcriptomic analysis, the identification of lncRNAs in plants has blossomed and caught up with the mammalian research field in a few years [ 11 ]. Long non-coding RNAs are transcribed by RNA polymerase II, similarly to mRNAs, and processed through 5′-capping and 3′ poly (A) addition.…”

Section: Introductionmentioning

confidence: 99%

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Long Non-Coding RNAs as Emerging Regulators of Pathogen Response in Plants

Sharma

Madhu

et al. 2022

ncRNA

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Long non-coding RNAs (lncRNAs) are transcripts without protein-coding potential that contain more than 200 nucleotides that play important roles in plant survival in response to different stresses. They interact with molecules such as DNA, RNA, and protein, and play roles in the regulation of chromatin remodeling, RNA metabolism, and protein modification activities. These lncRNAs regulate the expression of their downstream targets through epigenetic changes, at the level of transcription and post-transcription. Emerging information from computational biology and functional characterization of some of them has revealed their diverse mechanisms of action and possible roles in biological processes such as flowering time, reproductive organ development, as well as biotic and abiotic stress responses. In this review, we have mainly focused on the role of lncRNAs in biotic stress response due to the limited availability of knowledge in this domain. We have discussed the available molecular mechanisms of certain known lncRNAs against specific pathogens. Further, considering that fungal, viral, and bacterial diseases are major factors in the global food crisis, we have highlighted the importance of lncRNAs against pathogen responses and the progress in plant research to develop a better understanding of their functions and molecular mechanisms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNAs as Emerging Regulators of Pathogen Response in Plants

Sharma

Madhu

et al. 2022

ncRNA

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“…Discoveries in lncRNA biology have aroused interest in probing the transcriptome profiles of different diseases. In the field of botany, the regulatory roles of lncRNAs in the occurrence and development of mycosis have been disclosed [ 222 , 223 ]. Strategies that utilize lncRNAs such as RNA interference (RNAi) to develop the resistance of plants to fungi are being studied as well [ 222 , 224 , 225 ].…”

Section: Lncrnas As Potential Therapeutic Targets For Hdts Against ...mentioning

confidence: 99%

LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection

Wang

Chen

et al. 2022

Pharmaceutics

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Despite various drugs work against Candida, candidiasis represents clinical management challenges worldwide due to the rising incidence and recurrence rate, as well as epidemics, of new drug-resistant pathogens. Recent insights into interactions between Candida and hosts contribute to exploring novel therapeutic strategies, termed host-directed therapies (HDTs). HDTs are viable adjuncts with good efficacy for the existing standard antifungal regimens. However, HDTs induce other response unintendedly, thus requiring molecular targets with highly specificity. Long noncoding RNAs (lncRNAs) with highly specific expression patterns could affect biological processes, including the immune response. Herein, this review will summarize recent advances of HDTs based on the Candida–host interaction. Especially, the findings and application strategies of lncRNAs related to the host response are emphasized. We propose it is feasible to target lncRNAs to modulate the host defense during Candida infection, which provides a new perspective in identifying options of HDTs for candidiasis.

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“…LncRNAs are RNA transcripts exceeding 200 nucleotides (nt) in length with no coding potential and are synthesized from non-functional genetic regions in eukaryotes [6]. LncRNAs act as recruiters, linkers, facilitators, traps, and signaling molecules for transcriptional, post-transcriptional, and translational regulations [7,8].…”

Section: Introductionmentioning

confidence: 99%

Expression Patterns and Regulation of Non-Coding RNAs during Synthesis of Cellulose in Eucalyptus grandis Hill

Zhan

Wang

Xie

et al. 2021

Forests

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Cellulose, an essential structural component in the plant cell wall and a renewable biomass resource, plays a significant role in nature. Eucalyptus’s excellent timber tree species (including Eucalyptus grandis Hill) provide many raw materials for the paper and wood industries. The synthesis of cellulose is a very complex process involving multiple genes and regulated by various biological networks. However, research on regulating associated genes and non-coding RNAs during cellulose synthesis in E. grandis remains lacking. In this study, the wood anatomical characteristics and chemical indexes of E. grandis were analyzed by taking three different parts (diameter at breast height (DBH), middle and upper part of the trunk) from the main stem of E. grandis as raw materials. The role of non-coding RNAs (Long non-coding RNA, lncRNA; Micro RNA, miRNA; Circle RNA, circRNA) on regulating candidate genes was presented, and the network map of ceRNA (Competing endogenous RNA) regulation during wood cellulose biosynthesis of E. grandis was constructed. The transcriptome sequencing of nine samples obtained from the trunk of the immature xylem in E. grandis at DBH, middle and upper parts had a 95.81 G clean reading, 57,480 transcripts, 7365 lncRNAs, and 5180 circRNAs. Each sample had 172–306 known miRNAs and 1644–3508 new miRNAs. A total of 190 DE-lncRNAs (Differentially expressed long non-coding RNAs), 174 DE-miRNAs (Differentially expressed micro RNAs), and 270 DE-circRNAs (Differentially expressed circle RNAs) were obtained by comparing transcript expression levels. Four lncRNAs and nine miRNAs were screened out, and the ceRNA regulatory network was constructed. LncRNA1 and lncRNA4 regulated the genes responsible for cellulose synthesis in E. grandis, which were overexpressed in 84K (Populus Alba × Populus glandulosa) poplar. The cellulose and lignin content in lncRNA4-oe were significantly higher than wild type 84K poplar and lncRNA1-oe. The average plant height, middle and basal part of the stem diameter in lncRNA4-oe were significantly higher than the wild type. However, there was no significant difference between the growth of lncRNA1-oe and the wild type. Further studies are warranted to explore the molecular regulatory mechanism of cellulose biosynthesis in Eucalyptus species.

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The Emerging Role of Long Non-Coding RNAs in Plant Defense Against Fungal Stress

Cited by 30 publications

References 99 publications

Long Non-Coding RNAs as Emerging Regulators of Pathogen Response in Plants

Long Non-Coding RNAs as Emerging Regulators of Pathogen Response in Plants

LncRNA: A Potential Target for Host-Directed Therapy of Candida Infection

Expression Patterns and Regulation of Non-Coding RNAs during Synthesis of Cellulose in Eucalyptus grandis Hill

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