The Emerging Role of LncRNA FENDRR in Multiple Cancers: A
Review

Fazaeli, Hoda; Sheikholeslami, Azar; Ghasemian, Fatemeh; Amini, Elaheh; Sheykhhasan, Mohsen

doi:10.2174/1566524022666220509122505

Cited by 8 publications

(5 citation statements)

References 134 publications

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“…They are further classified based on the average size of nucleotides. Long ncRNAs (lncRNAs) are one of the major sub-grouped regulatory RNAs defined by RNA transcript lengths larger than 200 nucleotides [ 4 , 5 , 6 , 7 ]. Based on their location with respect to protein-coding genes, lncRNAs are distinguished into long intergenic ncRNAs (lincRNAs), long intronic ncRNAs, sense or anti-sense lncRNAs, and bidirectional lncRNA.…”

Section: Introductionmentioning

confidence: 99%

FLVCR1-AS1 and FBXL19-AS1: Two Putative lncRNA Candidates in Multiple Human Cancers

Sheykhhasan

Tanzadehpanah

Yazdi

et al. 2022

ncRNA

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(1) Background: Mounting evidence supports the idea that one of the most critical agents in controlling gene expression could be long non-coding RNAs (lncRNAs). Upregulation of lncRNA is observed in the different processes related to pathologies, such as tumor occurrence and development. Among the crescent number of lncRNAs discovered, FLVCR1-AS1 and FBXL19-AS1 have been identified as oncogenes in many cancer progression and prognosis types, including cholangiocarcinoma, gastric cancer, glioma and glioblastoma, hepatocellular carcinoma, lung cancer, ovarian cancer, breast cancer, colorectal cancer, and osteosarcoma. Therefore, abnormal FBXL19-AS1 and FLVCR1-AS1 expression affect a variety of cellular activities, including metastasis, aggressiveness, and proliferation; (2) Methods: This study was searched via PubMed and Google Scholar databases until May 2022; (3) Results: FLVCR1-AS1 and FBXL19-AS1 participate in tumorigenesis and have an active role in impacting several signaling pathways that regulate cell proliferation, migration, invasion, metastasis, and EMT; (4) Conclusions: Our review focuses on the possible molecular mechanisms in a variety of cancers regulated by FLVCR1-AS1 and FBXL19-AS1. It is not surprising that there has been significant interest in the possibility that these lncRNAs might be used as biomarkers for diagnosis or as a target to improve a broader range of cancers in the future.

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Section: Introductionmentioning

confidence: 99%

FLVCR1-AS1 and FBXL19-AS1: Two Putative lncRNA Candidates in Multiple Human Cancers

Sheykhhasan

Tanzadehpanah

Yazdi

et al. 2022

ncRNA

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“…In A549/DDP cells, FENDRR inhibits chemotherapy resistance by modulating ABCC1, a member of the ABC transporter superfamily. 51 …”

Section: Lncrna In Tumorigenesis and Chemotherapy Resistancementioning

confidence: 99%

Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm

Zhang,

Wu,

Wang

et al. 2024

DDDT

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In the past few decades, chemotherapy has been one of the most effective cancer treatment options. Drug resistance is currently one of the greatest obstacles to effective cancer treatment. Even though drug resistance mechanisms have been extensively investigated, they have not been fully elucidated. Recent genome-wide investigations have revealed the existence of a substantial quantity of long non-coding RNAs (lncRNAs) transcribed from the human genome, which actively participate in numerous biological processes, such as transcription, splicing, epigenetics, the cell cycle, cell differentiation, development, pluripotency, immune microenvironment. The abnormal expression of lncRNA is considered a contributing factor to the drug resistance. Furthermore, drug resistance may be influenced by genetic and epigenetic variations, as well as individual differences in patient treatment response, attributable to polymorphisms in metabolic enzyme genes. This review focuses on the mechanism of lncRNAs resistance to target drugs in the study of tumors with high mortality, aiming to establish a theoretical foundation for targeted therapy.

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“…miRNAs and lncRNAs play key roles in gene regulation and cancer biology. miRNAs are small non-coding RNAs that are known to bind and control mRNA expression [27][28][29][30][31]. In the ceRNA network, lncRNAs act as miRNAs to regulate gene expression and participate in cancer development.…”

Section: Fig 8 the Relationship Between Different Gene Expressions An...mentioning

confidence: 99%

Exploring the relationship between immune heterogeneity characteristic genes of rheumatoid arthritis and acute myeloid leukemia

Jiang,

Liu

et al. 2024

Discov Onc

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Background People with autoimmune diseases are prone to cancer, and there is a close relationship between rheumatoid arthritis (RA) and acute myeloid leukemia (AML). The bone marrow (BM) is affected throughout the course of RA, with a variety of hematologic involvement. Hopes are pinned on rheumatoid arthritis research to obtain BM biomarkers for AML. Methods Synovial transcriptome sequencing data for RA and osteoarthritis (OA), and single-cell sequencing data for RA and controls were obtained from the GEO database.Bone marrow sequencing data for AML patients and normal subjects were obtained from the UCSC Xena database. The final immune heterogeneity characteristics of RA were determined through ssGSEA analysis, gene differential expression analysis, fuzzy c-means clustering algorithm, and XGboost algorithm. Random Ferns classifiers (RFs) are used to identify new bone marrow markers for AML. Results SELL, PTPRC, IL7R, CCR7, and KLRB1 were able to distinguish leukemia cells from normal cells well, with AUC values higher than 0.970. Conclusion Genes characterizing the immune heterogeneity of RA are associated with AML, and KLRBA may be a potential target for AML treatment.

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The Emerging Role of LncRNA FENDRR in Multiple Cancers: A Review

Cited by 8 publications

References 134 publications

FLVCR1-AS1 and FBXL19-AS1: Two Putative lncRNA Candidates in Multiple Human Cancers

FLVCR1-AS1 and FBXL19-AS1: Two Putative lncRNA Candidates in Multiple Human Cancers

Research Progress of Long Non-Coding RNA in Tumor Drug Resistance: A New Paradigm

Exploring the relationship between immune heterogeneity characteristic genes of rheumatoid arthritis and acute myeloid leukemia

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