The emerging role of circadian rhythms in the development and function of thermogenic fat

Peng, Xuemin; Chen, Yong

doi:10.3389/fendo.2023.1175845

Cited by 2 publications

(1 citation statement)

References 116 publications

(152 reference statements)

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“…An altered circadian rhythm is associated with obesity and obesity-related metabolic disorders. BAT may play an important role in this process as it has a high capacity to burn fat and release energy as heat, supporting the fight against obesity and its associated metabolic disorders [135].…”

Section: Circadian Rhythm and Brown Fat Activationmentioning

confidence: 99%

Beyond the Cold: Activating Brown Adipose Tissue as an Approach to Combat Obesity

Negroiu,

Tudorașcu,

Bezna

et al. 2024

JCM

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With a dramatic increase in the number of obese and overweight people, there is a great need for new anti-obesity therapies. With the discovery of the functionality of brown adipose tissue in adults and the observation of beige fat cells among white fat cells, scientists are looking for substances and methods to increase the activity of these cells. We aimed to describe how scientists have concluded that brown adipose tissue is also present and active in adults, to describe where in the human body these deposits of brown adipose tissue are, to summarize the origin of both brown fat cells and beige fat cells, and, last but not least, to list some of the substances and methods classified as BAT promotion agents with their benefits and side effects. We summarized these findings based on the original literature and reviews in the field, emphasizing the discovery, function, and origins of brown adipose tissue, BAT promotion agents, and batokines. Only studies written in English and with a satisfying rating were identified from electronic searches of PubMed.

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Section: Circadian Rhythm and Brown Fat Activationmentioning

confidence: 99%

Beyond the Cold: Activating Brown Adipose Tissue as an Approach to Combat Obesity

Negroiu,

Tudorașcu,

Bezna

et al. 2024

JCM

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Chronic Unpredictable Mild Stress Affects Weight Changes Through Circadian Cycle Mechanism

Puriastuti,

Maramis,

Annas

et al. 2024

International Journal of Disabilities Sports and Health Sciences

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Everyday stress is unpredictable and comes in many different forms. The person is constantly exposed to stress because they cannot handle it. Chronic stress results from this illness. Chronic stress can affect changes in the body's standard mechanisms, including body weight modulated by the circadian cycle. Due to the fact that each person's response to stress is unique, stressful situations might result in two different variations in body weight. The purpose of this study is tobserve the effect of the CUMS on weight changes in Rattus novergicus through the circadian cycle mechanism. 16 chronic stress models of the Rattus norergicus were split into control and treatment groups. The chronic stress was provided using the Chronic Unpredictable Mild Stress (CUMS) approach. The control group did not receive any treatment but was still given maintenance such as providing food, drink and measuring their body weight every day. While the treatment group received CUMs for 20 days. Every morning before the stressor exposure, body weight was recorded. And the measurement of corticosterone levels using the Enzyme-Linked Immunoassay (ELISA) method with the Duplo technique. Before termination, blood is taken at the heart. Corticosterone levels varied across the groups (p = 0.032). The study's changes in body weight (p = 0.00) revealed a difference between the control and treatment groups, with the treatment group's weight being -11.15 ± 7.91. Chronic stress can alter how the body normally functions, mainly how the circadian cycle regulates body weight. Since each person's response to stress is unique, stressful situations might result in two different variations in body weight.

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The emerging role of circadian rhythms in the development and function of thermogenic fat

Cited by 2 publications

References 116 publications

Beyond the Cold: Activating Brown Adipose Tissue as an Approach to Combat Obesity

Beyond the Cold: Activating Brown Adipose Tissue as an Approach to Combat Obesity

Chronic Unpredictable Mild Stress Affects Weight Changes Through Circadian Cycle Mechanism

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