The emergence of sedentary behaviour physiology and its effects on the cardiometabolic profile in young and older adults

Ryan, Declan; Stebbings, Georgina K.; Onambélé, Gladys L.

doi:10.1007/s11357-015-9832-7

Cited by 31 publications

(21 citation statements)

References 76 publications

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“…5,36,37 There is growing evidence demonstrating that sedentary behavior has adverse effects on blood pressure, vascular function, glucose regulation, and inflammation, which is relevant because these factors have also been associated with declines in kidney function. 36,[38][39][40][41][42][43][44][45] In contrast to our findings with eGFR, we did not see an association between sedentary time and albuminuria. Reasons for this are not fully clear.…”

Section: Discussioncontrasting

confidence: 99%

Sedentary Behavior and Change in Kidney Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

et al. 2021

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Background: There is accumulating evidence linking prolonged sedentary time to adverse health outcomes. The impact of sedentary behavior on kidney function has not been evaluated in U.S. Hispanics/Latinos, a population disproportionately affected by chronic kidney disease (CKD). Methods: We evaluated the association between accelerometer measured (one week) sedentary time at baseline and kidney function among 7,134 adults without CKD at entry in the Hispanic Community Health Study/ Study of Latinos (HCHS/SOL), who completed a baseline visit with accelerometry (2008-2011) and a follow-up visit (2014-2017). Outcomes included: 1) change in kidney function (estimated glomerular filtration rate [eGFR] and urine albumin-to-creatinine ratio [ACR]), 2) incident low eGFR (eGFR <60 ml/min/1.73m2 and eGFR decline ≥1 mL/min/year), and 3) incident albuminuria (ACR ≥17 mg/g in men or ≥25 mg/g in women). Linear regression using survey procedures was used to evaluate change in kidney function (eGFR and ACR), and Poisson regression with robust variance was used to evaluate incident low eGFR and albuminuria. Results: The median sedentary time was 12 hours/day. Over a median follow-up of 6.1 years, the mean relative change in eGFR was -0.50% per year, and there were 167 incident low eGFR events. On multivariable analysis, each one hour increase in sedentary time was associated with a longitudinal decline in eGFR (-0.06% per year [95% CI, -0.10 to -0.02]). There was a significant interaction with sex, and on stratified analyses, higher sedentary time was associated with eGFR decline in women but not men. There was no association between sedentary time and the other outcomes. Conclusion: Sedentary time was associated with a small longitudinal decline in eGFR, which could have important implications in a population that experiences a disproportionate burden of CKD but further investigation is needed.

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Section: Discussioncontrasting

confidence: 99%

Sedentary Behavior and Change in Kidney Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

et al. 2021

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“…However, physical inactivity and sedentary behaviour are common among older people which can lead to an acceleration in muscle catabolism as well as reduced aerobic capacity. In conjunction with other personal, social and environmental factors (such as access to food and social isolation), a decline in physical activity can create a spiral of further inactivity, muscle loss, weight gain, mobility disability and an increase in cardio-metabolic risk [ 8 , 9 ]. Therefore, measurement and monitoring of PA and improved understanding of its associations with health outcomes are important to inform public health policy.…”

Section: Introductionmentioning

confidence: 99%

Associations Between Objectively Measured Physical Activity, Body Composition and Sarcopenia: Findings from the Hertfordshire Sarcopenia Study (HSS)

et al. 2018

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Regular physical activity (PA) is associated with reduced risk of the development and progression of musculoskeletal, metabolic and vascular disease. However, PA declines with age and this can contribute to multiple adverse outcomes. The aims of this study were to describe the relationship between accelerometer-determined PA, body composition and sarcopenia (the loss of muscle mass and function with age). Seven-day PA was measured using the GENEactiv accelerometer among 32 men and 99 women aged 74–84 years who participated in the Hertfordshire Sarcopenia Study. We measured mean daily acceleration and minutes/day spent in non-sedentary and moderate-to-vigorous physical activity (MVPA) levels. Body composition was measured by dual-energy X-ray absorptiometry, muscle strength by grip dynamometry and function by gait speed. Sarcopenia was defined according to the EWGSOP diagnostic algorithm. Men and women spent a median (inter-quartile range) of 138.8 (82, 217) and 186 (122, 240) minutes/day engaging in non-sedentary activity but only 14.3 (1.8, 30.2) and 9.5 (2.1, 18.6) min in MVPA, respectively. Higher levels of PA were associated with reduced adiposity, faster walking speed and decreased risk of sarcopenia. For example, a standard deviation (SD) increase in mean daily acceleration was associated with an increase in walking speed of 0.25 (95% CI 0.05, 0.45) SDs and a reduction in the risk of sarcopenia of 35% (95% CI 1, 57%) in fully adjusted analyses. PA was not associated with hand grip strength. Community-dwelling older adults in this study were largely sedentary but there was evidence that higher levels of activity were associated with reduced adiposity and improved function. PA at all intensity levels in later life may help maintain physical function and protect against sarcopenia.Electronic supplementary materialThe online version of this article (10.1007/s00223-018-0413-5) contains supplementary material, which is available to authorized users.

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“…Adult employees spend the majority of their day in a seated position, with research reporting that call centre workers in Europe can spend as much as 90% of their working day in a sedentary posture [1, 2]. It is also well recognised that the work environment is associated with an individual’s health and wellbeing status [3, 4]. Specific to the office work setting, there is a considerable body of evidence that suggests that there is an association between poor workstation setup and upper extremity body region pain and discomfort, which may increase an individual’s risk of musculoskeletal disorder when using a seated workstation environment [5, 6].…”

Section: Introductionmentioning

confidence: 99%

Current and ceased users of sit stand workstations: a qualitative evaluation of ergonomics, safety and health factors within a workplace setting

Henderson¹,

Stuckey

Keegel

2018

BMC Public Health

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BackgroundMany workplaces have implemented sit-stand workstations (SSW), which enable a worker to transition between sitting and standing as they perform their work activities. The factors which determine the initial adoption, sustainability or cessation of use for a SSW, remain largely unexamined. This study investigates the experiences of workers who had previously used or were currently using a SSW.MethodsThe study setting was within an Australian university. Participants who were current or past SSW users, as well as workplace key informants, were interviewed for the study. All interviews were recorded, transcribed and analysed. Transcripts were coded by two researchers for concepts and themes regarding uptake and sustainability of SSW. Discussion and validation of themes was undertaken by the team of three researchers.ResultsA total of 24 interviews were conducted. Twenty-two interviews were with ceased and current users (16 current and six ceased users) and two interviews were with workplace key informants. Analysis of the interviews with current and ceased users identified three main themes: Personal considerations for use/sustainability; Posture; and Usability. Analysis of the interviews with key informants identified two themes: Considerations and concerns and Policies and procedures. Little information was provided to workers when first using a SSW. Workers who were able to adopt their working style to the new workstations were able to sustain ongoing use of a SSW. Key informants were concerned that employees believed using a SSW would provide a health benefit in its own right without an understanding of the possible risks that might be associated with use.ConclusionsSustainable usage of this type of SSW is achievable, however, it requires some element of adaptation at the individual worker level. Participants spoke about how the use of the SSW in a standing position was typically associated with the time of day, specific task selection and musculoskeletal comfort or fatigue factors. The provision of education to new SSW users with relevant supporting information by a subject matter expert should enable the worker to obtain a more holistic understanding of the safety and health risks and benefits embedded in the use of a SSW.Electronic supplementary materialThe online version of this article (10.1186/s12889-018-6296-6) contains supplementary material, which is available to authorized users.

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The emergence of sedentary behaviour physiology and its effects on the cardiometabolic profile in young and older adults

Cited by 31 publications

References 76 publications

Sedentary Behavior and Change in Kidney Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Sedentary Behavior and Change in Kidney Function: The Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Associations Between Objectively Measured Physical Activity, Body Composition and Sarcopenia: Findings from the Hertfordshire Sarcopenia Study (HSS)

Current and ceased users of sit stand workstations: a qualitative evaluation of ergonomics, safety and health factors within a workplace setting

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