The emergence of nanoporous materials in lung cancer therapy

Radhakrishnan, Deepika; Mohanan, Shan; Choi, Gun; Choy, Jin-Ho; Tiburcius, Steffi; Trinh, Hoang Trung; Bolan, Shankar; Verrills, Nicole M.; Tanwar, Pradeep S.; Karakoti, Ajay; Vinu, Ajayan

doi:10.1080/14686996.2022.2052181

Cited by 21 publications

(5 citation statements)

References 329 publications

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“…Lung cancer is one of the most prevalent forms of tumors and continues to be the primary contributor to cancer-related deaths, responsible for 18.4% of all total fatalities. [21,179] Lung cancer can be classified into two main types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC is the more common type, accounting for over 80% of cases.…”

Section: Lung Cancermentioning

confidence: 99%

“…In this regard, early cancer detection becomes a life-saving support for patients to accelerate various treatment processes including nanodrug delivery. [4,[17][18][19][20][21][22][23] A sensitive and accurate cancer diagnosis is a highly efficient approach for enhancing their chances of survival, particularly in developing countries. [24][25][26] Conventional cancer diagnosis methods typically employ noninvasive nuclear-based imaging techniques, including magnetic resonance imaging (MRI), computed tomography (CT), ultrasonography, positron emission tomography (PET), and single-photon emission computed tomography.…”

Section: Introductionmentioning

confidence: 99%

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Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

Britto,

Guan,

Tran

et al. 2024

Small Science

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Despite significant advancements in medical technology, cancer remains the world's second‐leading cause of death, largely attributed to late‐stage diagnoses. While traditional cancer detection methodologies offer foundational insights, they often lack the specificity, affordability, and sensitivity for early‐stage identification. In this context, the development of biosensors offers a distinct possibility for the precise and rapid identification of cancer biomarkers. Carbon nanomaterials, including graphene, carbon nitride, carbon quantum dots, and other carbon‐based nanostructures, are highly promising for cancer detection. Their simplicity, high sensitivity, and cost‐effectiveness contribute to their potential in this field. This review aims to elucidate the potential of emerging carbon‐nanomaterial‐based biosensors for early cancer diagnosis. The relevance of the various biosensor mechanisms and their performance to the physicochemical properties of carbon nanomaterials is discussed in depth, focusing on demonstrating broad methodologies for creating performance biosensors. Diverse carbon‐nanomaterial‐based detection techniques, such as electrochemical, fluorescence, surface plasmon resonance, electrochemiluminescence, and quartz crystal microbalance, are emphasized for early cancer detection. At last, a summary of existing challenges and future outlook in this promising field is elaborated.

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Section: Lung Cancermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

Britto,

Guan,

Tran

et al. 2024

Small Science

Self Cite

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“…The preparation of LDH nanomaterials involves a variety of synthetic methods, including co-dispersion, ion exchange and hydrothermal methods. [21] Kankala et al extensively differentiated the syntheses for the fabrication of LDHs and their composites. [22] By creating materials with different structural and physicochemical properties, LDH have the potential for a wide range of applications in imaging and cancer therapy.…”

Section: Ldh Preparationmentioning

confidence: 99%

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Ma,

Chen,

Qiao

2024

The Chemical Record

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Layered double hydroxides (LDH) are a class of functional anionic clays that typically consist of orthorhombic arrays of metal hydroxides with anions sandwiched between the layers. Due to their unique properties, including high chemical stability, good biocompatibility, controlled drug loading, and enhanced drug bioavailability, LDHs have many potential applications in the medical field. Especially in the fields of bioimaging and tumor therapy. This paper reviews the research progress of LDHs and their nanocomposites in the field of tumor imaging and therapy. First, the structure and advantages of LDH are discussed. Then, several commonly used methods for the preparation of LDH are presented, including co‐precipitation, hydrothermal and ion exchange methods. Subsequently, recent advances in layered hydroxides and their nanocomposites for cancer imaging and therapy are highlighted. Finally, based on current research, we summaries the prospects and challenges of layered hydroxides and nanocomposites for cancer diagnosis and therapy.

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“…The study of mesoporous materials traces its origins to the late 1960s and early 1970s when researchers discovered the existence of ordered porous structures in various materials. Initial investigations focused on mesoporous materials like MCM-41 and SBA-15, which laid the foundation for the development of MSNs [8].…”

Section: Discovery Of Mesoporous Materialsmentioning

confidence: 99%

Fabrication of Mesoporous Silica Nanoparticles and Its Applications in Drug Delivery

Pande,

Kothawade,

Kuskar

et al. 2023

Nanotechnology and Nanomaterials

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Mesoporous Silica Nanoparticles (MSNs) are nano-sized particles with a porous structure that offers unique advantages for drug delivery systems. The chapter begins with an introduction to MSNs, providing a definition of these nanoparticles along with a brief historical overview. The distinctive properties of MSNs, such as high surface area, tunable pore size, and excellent biocompatibility, are discussed, highlighting their potential in drug delivery applications. The synthesis methods for MSNs are presented, including template-assisted synthesis, sol-gel method, co-condensation method, and other approaches. The chapter also covers the characterization techniques used for evaluating MSNs, including morphological, structural, and chemical characterization, which are crucial for assessing their quality and functionality. The surface modification of MSNs is explored, focusing on the functionalization of surface groups, attachment of targeting ligands, and surface charge modification to enhance their interactions with specific cells or tissues. The chapter then delves into the diverse applications of MSNs, with a particular focus on drug delivery. The use of MSNs in cancer theranostics, drug delivery, imaging, biosensing, and catalysis is discussed, emphasizing their potential to revolutionize these areas. Furthermore, the toxicity and biocompatibility of MSNs are addressed, covering both in vitro and in vivo studies that evaluate their safety and efficacy.

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The emergence of nanoporous materials in lung cancer therapy

Cited by 21 publications

References 329 publications

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

Emerging Multifunctional Carbon‐Nanomaterial‐Based Biosensors for Cancer Diagnosis

Advances of Layered Double Hydroxide‐Based Materials for Tumor Imaging and Therapy

Fabrication of Mesoporous Silica Nanoparticles and Its Applications in Drug Delivery

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