The emergence of mechanoregulated endochondral ossification in evolution

Khayyeri, Hanifeh; Prendergast, Patrick J.

doi:10.1016/j.jbiomech.2012.11.030

Cited by 3 publications

(2 citation statements)

References 56 publications

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“…It is well known that mechanical force plays significant role in MSC differentiation and mechanoregulation of skeletogenesis [55, 56]. Under the mechanical environment of knee joint, the subchondral bone is induced to migrate from surrounding bone part into the defect center (as illustrated in Figures 4, 5, 6, and 7, as evidenced by the cartilage tissue underlying the migrated subchondral bone), which in turn becomes maturation gradually.…”

Section: Discussionmentioning

confidence: 99%

Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites: A One-Year-Period Study in Rabbit Trochlea

Zhang

Lian

et al. 2014

BioMed Research International

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Increasing evidences show that subchondral bone may play a significant role in the repair or progression of cartilage damage in situ. However, the exact change of subchondral bone during osteochondral repair is still poorly understood. In this paper, biphasic osteochondral composite scaffolds were fabricated by 3D printing technology using PEG hydrogel and β-TCP ceramic and then implanted in rabbit trochlea within a critical size defect model. Animals were euthanized at 1, 2, 4, 8, 16, 24, and 52 weeks after implantation. Histological results showed that hyaline-like cartilage formed along with white smooth surface and invisible margin at 24 weeks postoperatively, typical tidemark formation at 52 weeks. The repaired subchondral bone formed from 16 to 52 weeks in a “flow like” manner from surrounding bone to the defect center gradually. Statistical analysis illustrated that both subchondral bone volume and migration area percentage were highly correlated with the gross appearance Wayne score of repaired cartilage. Therefore, subchondral bone migration is related to cartilage repair for critical size osteochondral defects. Furthermore, the subchondral bone remodeling proceeds in a “flow like” manner and repaired cartilage with tidemark implies that the biphasic PEG/β-TCP composites fabricated by 3D printing provides a feasible strategy for osteochondral tissue engineering application.

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Section: Discussionmentioning

confidence: 99%

Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites: A One-Year-Period Study in Rabbit Trochlea

Zhang

Lian

et al. 2014

BioMed Research International

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“…It has also been hypothesized that novel mechanical forces acting on skeletons, such as gravity on the bones of fish out of water, could give rise to evolutionary innovations in bone structure (Danos and Staab, 2010). Mechanosensitive fish osteoblasts may have thus served as a valuable exaptation for producing a strong, stiff, weight-responsive skeleton during the tetrapod invasion of land (Khayyeri and Prendergast, 2013;Doherty et al, 2015).…”

Section: Evolution Of Weight Sensing In Vertebratesmentioning

confidence: 99%

Skeletal stiffening in an amphibious fish out of water is a response to increased body weight

Turko

Kültz

Fudge

et al. 2017

Journal of Experimental Biology

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Terrestrial animals must support their bodies against gravity, while aquatic animals are effectively weightless because of buoyant support from water. Given this evolutionary history of minimal gravitational loading of fishes in water, it has been hypothesized that weight-responsive musculoskeletal systems evolved during the tetrapod invasion of land and are thus absent in fishes. Amphibious fishes, however, experience increased effective weight when out of water - are these fishes responsive to gravitational loading? Contrary to the tetrapod-origin hypothesis, we found that terrestrial acclimation reversibly increased gill arch stiffness (∼60% increase) in the amphibious fish when loaded normally by gravity, but not under simulated microgravity. Quantitative proteomics analysis revealed that this change in mechanical properties occurred via increased abundance of proteins responsible for bone mineralization in other fishes as well as in tetrapods. Type X collagen, associated with endochondral bone growth, increased in abundance almost ninefold after terrestrial acclimation. Collagen isoforms known to promote extracellular matrix cross-linking and cause tissue stiffening, such as types IX and XII collagen, also increased in abundance. Finally, more densely packed collagen fibrils in both gill arches and filaments were observed microscopically in terrestrially acclimated fish. Our results demonstrate that the mechanical properties of the fish musculoskeletal system can be fine-tuned in response to changes in effective body weight using biochemical pathways similar to those in mammals, suggesting that weight sensing is an ancestral vertebrate trait rather than a tetrapod innovation.

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2015

Bones and Cartilage

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The emergence of mechanoregulated endochondral ossification in evolution

Cited by 3 publications

References 56 publications

Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites: A One-Year-Period Study in Rabbit Trochlea

Cartilage Repair and Subchondral Bone Migration Using 3D Printing Osteochondral Composites: A One-Year-Period Study in Rabbit Trochlea

Skeletal stiffening in an amphibious fish out of water is a response to increased body weight

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