The Embryo and Its Future1

Fleming, Tom P.; Kwong, Wing Yee; Porter, Robert H.; Ursell, Elizabeth; Fesenko, Irina; Wilkins, Adrian; Miller, Daniel J.; Watkins, Adam; Eckert, Judith

doi:10.1095/biolreprod.104.030957

Cited by 307 publications

(234 citation statements)

References 153 publications

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“…The size of first two cell lineages (ICM and TE) as well as their ratio influence future growth, viability, and implantation potential of the blastocyst. A positive relationship between cell number and morphology of the ICM and the rate of embryo implantation and post-implantation developmental potential were evidenced in experimental and clinical studies [1,23]. Based on our experimental data and on these findings we hypothesize that the lineage specification defect and the loss of ICM integrity may suggest one of the possible pathways through which increased risk of clinical early pregnancy loss is triggered in women exposed to high levels of ambient PM 10 .…”

Section: Discussionsupporting

confidence: 60%

“…The preimplantation period of development represents a critical time during which the embryo is highly susceptible to exogenous insults that can affect future growth and developmental potential, either pre-and/or postnatally [1]. Abnormalities in developmental potential may arise from the unavoidable maternal exposure to environmental toxic agents during the periconceptional period affecting not only reproductive but also pregnancy outcome and/or postnatal life [2,3].…”

Section: Introductionmentioning

confidence: 99%

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Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Perin

Maluf

Czeresnia

et al. 2010

J Assist Reprod Genet

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Purpose To assess the potential effects of short-term exposure to particulate air pollution during follicular phase on clinical, laboratory, and pregnancy outcomes of women undergoing IVF/ET. Methods Retrospective cohort study of 400 first IVF/ET cycles of women exposed to ambient particulate matter during follicular phase. Particulate matter (PM) was categorized into quartiles (Q 1 : ≤30.48 µg/m 3 , Q 2 : 30.49-42.00 µg/m 3 , Q 3 : 42.01-56.72 µg/m 3 , and Q 4 : >56.72 µg/m 3 ). Results Clinical, laboratory, or treatment variables were not affected by follicular phase PM exposure periods. Women exposed to Q 4 period during the follicular phase of conception cycles had a higher risk of miscarriage (odds ratio, 5.05; 95% confidence interval: 1.04-25.51) when compared to women exposed to Q 1-3 periods. Conclusion Our results show an association between brief exposure to high levels of ambient PM during the preconceptional period and early pregnancy loss, although no effect of this exposure on clinical, laboratory, and treatment outcomes was observed.

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Section: Discussionsupporting

confidence: 60%

Section: Introductionmentioning

confidence: 99%

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Perin

Maluf

Czeresnia

et al. 2010

J Assist Reprod Genet

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“…From fertilization to 186" implantation, embryonic development is influenced during its migration by the maternal 187" environment (Fleming et al, 2004). As the current results show, the oviduct exhibits a 188" spatial-temporal pattern of transcripts involved in peri-implantation events.…”

Section: "mentioning

confidence: 54%

Oviductal and endometrial mRNA expression of implantation candidate biomarkers during early pregnancy in rabbit

Saeed¹,

Saenz-de-Juano

Marco‐Jiménez

et al. 2013

Zygote

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SummaryPrenatal losses are a complex problem. Pregnancy requires orchestrated communication between the embryo and the uterus that includes secretions from the embryo to signal pregnancy recognition and secretion and remodelling from the uterine epithelium. Most of these losses are characterized by asynchronization between embryo and uterus. To better understand possible causes, an analysis was conducted of gene expression of a set of transcripts related to maternal recognition and establishment of rabbit pregnancy (uteroglobin, SCGB1A1; integrin α1, ITGA1; interferon-γ, IFNG; vascular endothelial growth factor, VEGF) in oviduct and uterine tissue at 16, 72 or 144 h post-ovulation and insemination. In the oviduct tissue, a significant decrease in the level of SCGB1A1 mRNA expression was observed from 144 h post-ovulation. In the case of ITGA1, the transcript abundance was initially lower, but mRNA expression increased significantly at 72 and 144 h post-ovulation. For IFNG, a huge decrease was observed from 16 to 72 h post-ovulation. Finally, no significant differences were observed in the VEGF transcript. For the endometrium, the results showed a significant decline in the level of SCGB1A1 mRNA expression from 16 to 144 h post-ovulation induction. The highest levels of ITGA1 transcript were detected at 144 h, followed by the 16 h group and lower at 72 h post-ovulation. For IFNG there were no significant differences among post-ovulation induction times. Finally, it was possible to observe that VEGF mRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but increased at 144 h. The functional significance of these observations may provide new insights into the maternal role in prenatal losses.

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“…Abnormally high or low rates of metabolism may impair oocyte and embryo development [62,63]. The idea that embryos and oocytes have a "quiet" metabolism was proposed in 2002 [64] and the nutritional excess provided by a high-fat or nutrient-rich diet may alter the metabolism and development.…”

Section: Lipidsmentioning

confidence: 99%

The impact of obesity on egg quality

Purcell

Moley

2011

J Assist Reprod Genet

132

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Obesity in women is a concern in many countries. This causes numerous health issues; however, this review focuses on the impact of obesity on women's reproduction, and in particular the oocyte. Data from infertility clinics and experimental animal models that address the effects of obesity are presented. Bidirectional communication and metabolic support from the surrounding cumulus cells are critical for oocyte development, and the impact of obesity on these cells is also addressed. Both oocyte maturation and metabolism are impaired due to obesity, negatively impacting further development. In addition to reproductive hormones, obesity induced elevations in insulin, glucose, or free fatty acids, and changes in adipokines appear to impact the developmental competence of the oocyte. The data indicate that any one of these hormones or metabolites can impair oocyte developmental competence in vivo, and the combination of all of these factors and their interactions are the subject of ongoing investigations.

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The Embryo and Its Future1

Cited by 307 publications

References 153 publications

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

Oviductal and endometrial mRNA expression of implantation candidate biomarkers during early pregnancy in rabbit

The impact of obesity on egg quality

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