The elusive small bowel adenocarcinoma in the terminal ileum—A case report

Gee, Joyce Lok; Strauss, Paul

doi:10.1016/j.ijscr.2018.04.021

Cited by 7 publications

(7 citation statements)

References 8 publications

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“…The most common clinical manifestations of IA are weight loss, vomiting, cramping abdominal pain, and occult gastrointestinal bleeding, but perforation is rare ( 8 , 10 – 13 ). Vomiting and nausea may persist throughout a pregnancy in approximately 10% of affected women ( 14 ), so these symptoms are easily attributed to pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Ileal adenocarcinoma in a young pregnant woman: A rare case report

Xiao

Cheng²,

Cao³

et al. 2023

Front. Oncol.

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Primary intestinal malignancies account for only 1%–3% of all malignant gastrointestinal tumors. Adenocarcinomas are uncommonly located in the ileum. Ileal adenocarcinoma (IA) is rare and difficult to diagnose because of its location. IA is common in older men and rare in young pregnant women. A 23-year-old pregnant woman was hospitalized several times for repeated vomiting and abdominal pain. Her symptoms were relieved after symptomatic treatment. She exhibited no typical manifestations of intestinal obstruction, such as abdominal distension, difficulty passing gas and defecation. Unfortunately, she was misdiagnosed with acute gastroenteritis. On the second day after delivery, the patient stopped passing gas and computed tomography (CT) revealed an intestinal obstruction. She was treated as paralytic ileus. However, in view of failed conservative management, she was decided for an exploratory laparotomy. A malignant ileal tumor 5cm from the ileocecal valve was found incidentally and was surgically excised accompanied with End-to-side anastomosis of ileal and transverse colon. The operation lasted 195 minutes. Pathological examination revealed an IA. Pregnant woman who experience symptoms of intestinal obstruction should be alert to the possibility of malignancy in the small intestine. IA is an insidious tumor in pregnant women. An “IA triad” can be defined as refractory vomiting, vague abdominal pain, and weight loss (or inadequate weight gain in pregnant women). Pregnant women with an IA triad should undergo investigation with endoscopy or, if necessary, magnetic resonance imaging (MRI).

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Section: Discussionmentioning

confidence: 99%

Ileal adenocarcinoma in a young pregnant woman: A rare case report

Xiao

Cheng²,

Cao³

et al. 2023

Front. Oncol.

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“…2 Small bowel adenocarcinoma is associated with conditions including familial adenomatous polyposis, celiac disease, adenoma, Peutz-Jeghers syndrome, Crohn's disease, smoking, and obesity. 2 The presenting symptoms, including abdominal pain, nausea and vomiting, and anemia, are often vague and non-specific, leading to a significant delay in diagnosis (average time to diagnosis of 2-8 months). 3 The mean age of diagnosis is 60 years.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Small Bowel Adenocarcinoma Mimicking a Primary Ovarian Mucinous Tumour – Clinical, Radiologic, Pathologic and Molecular Correlation

et al. 2022

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We describe an interesting case of a patient who presented with a large adnexal mass, first favored to be mucinous carcinoma of the gynecologic origin. The primary tumour site was ascertained after the patient's small bowel was resected by identifying an adenomatous component evolving into an invasive adenocarcinoma identical in morphology and immunophenotype to the ovarian tumour. Notably, both tumours were found to harbor a BRAF K601E mutation, which is extremely rare for a primary of the ovary. BRAF mutations are present in a subset of large bowel and small bowel adenocarcinoma, but our case shows the first instance of a BRAF K601E mutation being present in a small bowel adenocarcinoma, to the best of our knowledge. This case serves as a great illustration of the pivotal role of molecular diagnostics in modern pathology in arriving at the correct diagnosis. Additionally, it is an excellent example of how clinical-radiologic-pathologic-molecular correlation plays into the landscape of molecular pathology to deliver optimal care for the patient.

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“…However, capsule endoscopy enables visualization of the entire small intestinal mucosa. Moreover, CT and MRI allow us to better observe the thickness of the mucosa and intestinal wall, which helps to examine the degree of tumor infiltration and the relationship with neighboring organs, to determine the possible occurrence of a distant metastasis [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Duodenal adenocarcinoma with skin metastasis as initial manifestation: A case report

Zheng

Huang

et al. 2021

Open Life Sciences

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Background Duodenal adenocarcinoma (DA) with skin metastasis as initial manifestation is clinically rare. In this study, we report a rare case of skin metastasis of DA. Case presentation An 84-year-old male patient developed multiple ecchymoses on the trunk and lower extremities. Physical examination showed that the ecchymosis was dark red and had a hard texture, but showed no bulging, rupture, or tenderness. The skin biopsy implied skin metastatic adenocarcinoma. After an endoscopic duodenal biopsy, the patient was finally diagnosed with DA with skin metastasis. The patient received two courses of oral treatment of Tegafur (40 mg, bid d1–d14). However, the patient stopped taking Tegafur because of its poor effect and received Chinese medicine as a replacement treatment. Unfortunately, he was lost to follow-up. Conclusions Early diagnosis of DA metastasis is of significant importance as prognosis of these patients is poor.

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The elusive small bowel adenocarcinoma in the terminal ileum—A case report

Cited by 7 publications

References 8 publications

Ileal adenocarcinoma in a young pregnant woman: A rare case report

Ileal adenocarcinoma in a young pregnant woman: A rare case report

Metastatic Small Bowel Adenocarcinoma Mimicking a Primary Ovarian Mucinous Tumour – Clinical, Radiologic, Pathologic and Molecular Correlation

Duodenal adenocarcinoma with skin metastasis as initial manifestation: A case report

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