The Elimination of Haemophilus influenzae type b Meningitis Following Conjugate Vaccine Introduction in Senegal

Cissé, Moussa; Breugelmans, J. Gabrielle; Ba, Mikutskaia; Diop, Mouhamadou; Faye, Pape Coumba; Mhlanga, B.; Mueller, Judith E.; Koffi, Djima; Gessner, Bradford D.

doi:10.1097/inf.0b013e3181ccb0a0

Cited by 26 publications

(15 citation statements)

References 19 publications

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“…[11][12][13] Introduction of Hib conjugate vaccines into the routine immunization schedule has led to near eradication of invasive Hib disease in many industrialized and transitional countries, and some developing countries. 11,[14][15][16][17] A serum anti-PRP titer 1.0 μg/mL, originally proposed by Kayhty and others 18 is now widely accepted in vaccinology and public health as a titer that is associated with long-term protection against invasive Hib disease. Accordingly, this is the most frequently used measure to assess the immunogenicity of Hib conjugate immunization schedules and to predict protection that will endure throughout the period of risk for infants, toddlers, and pre-school children.…”

Section: Introductionmentioning

confidence: 99%

Naturally Acquired and Conjugate Vaccine-Induced Antibody to Haemophilus influenzae Type b (Hib) Polysaccharide in Malian Children: Serological Assessment of the Hib Immunization Program in Mali

Hütter¹,

Pasetti²,

Sanogo³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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Abstract. Haemophilus influenzae type b (Hib) conjugate vaccine for infants (6, 10, and 14 weeks of age) was introduced into the Malian Expanded Program on Immunization in July 2005, to diminish invasive Hib disease in young children. Antibodies to Hib capsular polysaccharide (PRP) were measured in infants and toddlers from an area already served by the Hib immunization program (Bamako) and in unimmunized children of the same age in a district (Kangaba) where Hib immunization had not yet begun. Among vaccinated Bamako children 6 -23 months of age, 77-93% exhibited PRP titers 1.0 μg/mL, indicating long-term protection, versus only 10 -23% of Kangaba children of that age. High PRP antibody titers in immunized children persisted through 2 years of age. Moreover,~50% of Bamako children exhibited anti-PRP titers 5.0 μg/mL; a level that impedes Hib upper respiratory carriage, and may thereby diminish the Hib transmission to the unimmunized susceptible population (i.e., providing indirect protection).

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Section: Introductionmentioning

confidence: 99%

Naturally Acquired and Conjugate Vaccine-Induced Antibody to Haemophilus influenzae Type b (Hib) Polysaccharide in Malian Children: Serological Assessment of the Hib Immunization Program in Mali

Hütter¹,

Pasetti²,

Sanogo³

et al. 2012

The American Society of Tropical Medicine and Hygiene

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“…Targeted strategies to vaccinate high-risk populations reduced or eliminated racial and ethnic disparities in rates of Hib disease incidence in Israel [91] and Australia [92,93] and of pneumococcal disease in the US [94] were decreased or eliminated following vaccine introduction. Populations not targeted by the vaccine experienced reductions in morbidity and mortality associated with Hib disease [24,39,91,[95][96][97][98][99][100], Streptococcus pneumoniae disease [43,83,[101][102][103][104][105][106][107], meningococcal disease [3,9,[108][109][110][111][112][113][114], hepatitis A [58], hepatitis B [115], typhoid fever [6], rotavirus diarrhea [116][117][118][119][120][121][122][123], human papilloma virus infection [124,125], and Japanese encephalitis [47]; these reductions were attributed to a herd protective effect.…”

Section: Financing and Sustainabilitymentioning

confidence: 99%

The impact of new vaccine introduction on immunization and health systems: A review of the published literature

Hyde

Dentz

Wang

et al. 2012

Vaccine

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We conducted a systematic review of the published literature to examine the impact of new vaccine introduction on countries' immunization and broader health systems. Six publication databases were searched using 104 vaccine and health system-related search terms. The search yielded 15,795 unique articles dating from December 31, 1911 to September 29, 2010. Based on review of the title and abstract, 654 (4%) of these articles were found to be potentially relevant and were referred for full review. After full review, 130 articles were found to be relevant and included in the analysis. These articles represented vaccines introduced to protect against 10 different diseases (hepatitis A, hepatitis B, Haemophilus influenzae type b disease, human papilloma virus infection, influenza, Japanese encephalitis, meningococcal meningitis, Streptococcus pneumoniae disease, rotavirus diarrhea and typhoid), in various formulations and combinations. Most reviewed articles (97 [75%]) reported experiences in high-income countries. New vaccine introduction was most efficient when the vaccine was introduced into an existing delivery platform and when introduced in combination with a vaccine already in the routine childhood immunization schedule (i.e., as a combination vaccine). New vaccine introduction did not impact coverage of vaccines already included in the routine childhood immunization schedule. The need for increased cold chain capacity was frequently reported. New vaccines facilitated the introduction and widespread use of auto-disable syringes into the immunization and the broader health systems. The importance of training and education for health care workers and social mobilization was frequently noted. There was evidence in high-income countries that new vaccine introduction was associated with reduced health-care costs. Future evaluations of new vaccine introductions should include the systematic and objective assessment of the impacts on a country's immunization system and broader health system, especially in lower-income countries.

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“…The incidence and severity of pneumonia and meningitis were reduced by Hib vaccination (9)(10)(11)(12)(13). Hib vaccination coverage increased in recent years.…”

Section: Introductionmentioning

confidence: 99%

Oropharyngeal Colonization of Haemophilus influenzae Type b and Serologic Response After Administration of Third Dose of Pentavalent Vaccine to 12-Month-Old Children in Karaj, Iran, 2016

Shirvani

Arjmand²,

Golami

et al. 2019

Arch Pediatr Infect Dis

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Background: The administration of Haemophilus influenzae type b (Hib) conjugate vaccine led to a decrease of over 90% in the prevalence of severe Hib diseases in the countries with universal coverage vaccine. After addition of Hib vaccine to the national vaccination program and since no study has yet investigated this subject. Objectives: The current study aimed at investigating the serologic response and assessing oropharyngeal colonization with Hib after the last dose of vaccine. Methods: A total of 500 blood and oropharyngeal samples were collected from one-year-old children referred to Karaj health care centers, Iran. Demographic information and risk factors of the children were collected. Oropharyngeal and blood samples were transferred to the laboratory to determine antibody titer by the enzyme-linked immunosorbent assay (ELISA) technique, culture testing, and polymerase chain reaction (PCR). Results: In the current study, 11.8% of children (95% confidence interval (CI): 8.97-14.63) had an anti-Hib IgG titer of ≥ 5 µg/mL. Geometric mean titer (GMT) of vaccine antibody was 6.92 µg/mL (95% CI: 6.76-7.08); 9% of oropharyngeal culture results were positive for H. influaenzae (non-type b) and 8.2% were confirmed by PCR. Prevalence of oropheryngeal Hib colonization was 0.02%. There was no significant correlation between the titer of H. influaenzae antibody and positive culture of H. influaenzae and the other studied variables (P > 0.05). Conclusions: In Iran, similar to most countries, pentavalent vaccine in national vaccination program decreased the prevalence of Hib colonization. Prevalence of Hib colonization is an important factor in invasive diseases incidence. It is suggested that further studies asses the prevalence of invasive Hib diseases after national vaccination.

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The Elimination of Haemophilus influenzae type b Meningitis Following Conjugate Vaccine Introduction in Senegal

Abstract: Senegal successfully implemented Hib conjugate vaccine into their routine infant immunization program with a resultant near elimination of Hib meningitis burden.

Cited by 26 publications

References 19 publications

Naturally Acquired and Conjugate Vaccine-Induced Antibody to Haemophilus influenzae Type b (Hib) Polysaccharide in Malian Children: Serological Assessment of the Hib Immunization Program in Mali

Naturally Acquired and Conjugate Vaccine-Induced Antibody to Haemophilus influenzae Type b (Hib) Polysaccharide in Malian Children: Serological Assessment of the Hib Immunization Program in Mali

The impact of new vaccine introduction on immunization and health systems: A review of the published literature

Oropharyngeal Colonization of Haemophilus influenzae Type b and Serologic Response After Administration of Third Dose of Pentavalent Vaccine to 12-Month-Old Children in Karaj, Iran, 2016

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