The electroretinogram in multiple sclerosis and demyelinating optic neuritis

Papakōstopoulos, D.; Fotiou, Fotis; Hart, Jane; Banerji, N.K.

doi:10.1016/0168-5597(89)90045-2

Cited by 43 publications

(24 citation statements)

References 20 publications

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“…This implies a level of dysfunction in several retinal layers. Previous electroretinographic studies on MS patients have found overall diminished ERG responses [26] and abnormalities of the b-wave [27][28][29]. A plausible explanation for this is still lacking in the literature.…”

Section: Discussionmentioning

confidence: 92%

Electroretinographic abnormalities in multiple sclerosis: possible role for retinal autoantibodies

et al. 2006

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Section: Discussionmentioning

confidence: 92%

Electroretinographic abnormalities in multiple sclerosis: possible role for retinal autoantibodies

et al. 2006

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“…Although MS is a systemic disease that may have separate subclinical effects in the retina of the ON and fellow eyes [14], there was no difference in the mean ERG and PERG values between the eyes in those patients with and without MS. There are some reports of reduced b-wave amplitudes in optic neuritis patients with and without MS, but no difference in a-wave amplitudes or peak-time [15,16]. However, one of those studies [15] did not record ISCEV Standard ERGs, using surface electrodes, and the other [16] only performed photopic ERGs and found ''reduction'' in both affected and unaffected eyes compared with a normal control group.…”

Section: Discussionmentioning

confidence: 92%

“…There are some reports of reduced b-wave amplitudes in optic neuritis patients with and without MS, but no difference in a-wave amplitudes or peak-time [15,16]. However, one of those studies [15] did not record ISCEV Standard ERGs, using surface electrodes, and the other [16] only performed photopic ERGs and found ''reduction'' in both affected and unaffected eyes compared with a normal control group. No such changes were observed in the present study population.…”

Section: Discussionmentioning

confidence: 92%

Electroretinogram findings in unilateral optic neuritis

Fraser

Holder

2011

Doc Ophthalmol

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To report the electrophysiological findings in patients with unilateral optic neuritis (ON), with particular reference to the electroretinogram (ERG). A retrospective analysis of full-field ERG, pattern ERG (PERG) and pattern visual evoked potential findings from 46 patients with clinical and electrophysiological findings in keeping with unilateral ON. ISCEV standard ERGs did not significantly differ between the optic neuritis and fellow eyes, nor between patients with and without MS. Differences were present in the N95 component of the PERG, which was significantly lower in the affected eye, and the pattern reversal visual evoked potential, which showed significantly longer peak time (latency) in the affected eye. In addition, there was a significant difference between patients with and without multiple sclerosis (MS). No significant inter-ocular asymmetry in ISCEV standard ERGs was present in these cases of unilateral optic neuritis, either as a clinically isolated syndrome or as part of multiple sclerosis. All ERGs recorded were normal.

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“…The etiology of the abnormal b-wave that we and others [40][41][42] have observed in MS patients remains unresolved. This likely indicates that factors affecting the retina other than α-enolase autoantibodies are contributing to the abnormal b-wave in MS patients.…”

Section: Discussionmentioning

confidence: 87%

“…The b-wave of the ERG arises from bipolar cells, with a significant contribution from glial Muller cells [39]. Previous ERG studies in MS have also revealed b-wave abnormalities in MS [40][41][42], and it has been speculated that this may be secondary to Muller cell dysfunction [42]. Animal experiments have shown that intravitreal injection of anti-enolase serum [38] and purified anti-enolase antibody [43] results in reduced b-wave amplitudes.…”

Section: Discussionmentioning

confidence: 97%

Enolase autoantibodies and retinal function in multiple sclerosis patients

Forooghian

Adamus

Sproule

et al. 2007

Graefes Arch Clin Exp Ophthalmol

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Factors affecting the retina other than alpha-enolase antibodies may account for the delayed rod-cone b-wave implicit times observed in MS patients in this study. Anti-enolase antibodies are likely an epiphenomenon of autoimmune disease, and are not causing retinopathy in MS patients with normal visual acuity. However, the possibility of rare cases of patients with pathogenic alpha-enolase autoantibodies can not be excluded. The pathogenic contribution of these antibodies in MS patients with visual impairment deserves further investigation.

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The electroretinogram in multiple sclerosis and demyelinating optic neuritis

Cited by 43 publications

References 20 publications

Electroretinographic abnormalities in multiple sclerosis: possible role for retinal autoantibodies

Electroretinographic abnormalities in multiple sclerosis: possible role for retinal autoantibodies

Electroretinogram findings in unilateral optic neuritis

Enolase autoantibodies and retinal function in multiple sclerosis patients

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