The electroretinogram and visual evoked potential of freely moving rats

Szabó-Salfay, Orsolya; Pálhalmi, János; Szatmári, E; Barabás, Péter; Szilágyi, Nóra; Juhász, Gábor

doi:10.1016/s0361-9230(01)00585-8

Cited by 29 publications

(36 citation statements)

References 25 publications

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“…In our previous studies with rats (Galambos et al, 2000Szabo-Salfay et al, 2001) the retina was illuminated from behind by LEDs glued to the skull. We undertook to simulate that unusual stimulus path in these human studies by delivering the stimuli through the closed eyelid.…”

Section: Experiments 4 Eye Closed Controlmentioning

confidence: 99%

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The human Retinal Functional Unit

Galambos

Juhász

Lőrincz

et al. 2005

International Journal of Psychophysiology

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Section: Experiments 4 Eye Closed Controlmentioning

confidence: 99%

“…It briefly summarizes previous results obtained from the Wistar rat, our model of the mammalian visual system (Galambos et al, 2000Szabo-Salfay et al, 2001). Two small LEDs glued to the rat's skull deliver red stimuli on command (continuous, intermittent, or both) as the animal sleeps or moves about in darkness within a small box.…”

Section: Introductionmentioning

confidence: 97%

The human Retinal Functional Unit

Galambos

Juhász

Lőrincz

et al. 2005

International Journal of Psychophysiology

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“…corneal ERGs from anaesthetized rats [4]; corneal and scleral ERGs by chronic implants from non-anaesthetized rats [53]), the SC (e.g. [9,30]), and the primary visual cortex (e.g.…”

Section: Discussionmentioning

confidence: 99%

The reflection of retinal light response information onto the superior colliculus in the rat

Valjakka

2007

Graefes Arch Clin Exp Ophthalmol

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The data suggest that the information properties of (a) intensity, (b) presentation time and, obviously, (c) colour of the light stimulus, such as are shed on the retina, and information about the light response bias of the retina are mediated correlatively and quantitatively to the cell network system of the SC through the optic nerve. These processes must happen during the a-to-b-wave phases of the ERG. The data indicate that the random-type variations in the activity of the related cellular systems may actually be harnessed in mediating the defined information properties of the visual stimulus from the retina to the SC of the brain through the optic nerve. This study shows a method of measuring the function of the optic nerve.

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“…Neuromuscular blockers and anaesthetic agents are used in ERG experimentation to achieve an unconscious and motionless state. There have only been five reports of awake ERG recordings in rats [16][17][18][19][20] . In these studies, electrodes were surgically pre-implanted into the skull and two of these studies tested the effect of anaesthesia on the ERG 17,20 .…”

Section: Anesthesiamentioning

confidence: 99%

“…Set the band pass filters to 1-1,000 Hz and ensure that sampling is triggered to sample the period of ~250 msec following a flash. 16 . An ERG waveform similar to Figure 2A should appear.…”

Section: Introductionmentioning

confidence: 99%

Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning

Brandli

Stone

2015

JoVE

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Citation: Brandli, A., Stone, J. Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning. J. Vis. Exp. (100), e52658, doi:10.3791/52658 (2015). AbstractThe ERG is the sum of all retinal activity. The ERG is usually recorded from the cornea, which acts as an antenna that collects and sums signals from the retina. The ERG is a sensitive measure of changes in retinal function that are pan-retinal, but is less effective for detecting damage confined to a small area of retina. In the present work we describe how to record the 'flash' ERG, which is the potential generated when the retina is exposed to a brief light flash. We describe methods of anaesthesia, mydriasis and corneal management during recording; how to keep the retina dark adapted; electrode materials and placement; the range and calibration of stimulus energy; recording parameters and the extraction of data. We also describe a method of inducing ischemia in one limb, and how to use the ERG to assess the effects of this remote-from-the-retina ischemia on retinal function after light damage. A two-flash protocol is described which allows isolation of the cone-driven component of the dark-adapted ERG, and thereby the separation of the rod and cone components. Because it can be recorded with techniques that are minimally invasive, the ERG has been widely used in studies of the physiology, pharmacology and toxicology of the retina. We describe one example of this usefulness, in which the ERG is used to assess the function of the light-damaged retina, with and without a neuroprotective intervention; preconditioning by remote ischemia. Video LinkThe video component of this article can be found at

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The electroretinogram and visual evoked potential of freely moving rats

Cited by 29 publications

References 25 publications

The human Retinal Functional Unit

The human Retinal Functional Unit

The reflection of retinal light response information onto the superior colliculus in the rat

Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning

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