The electrophysiology of aphasia: A scoping review

Meechan, Ryan J. H.; McCann, Clare; Purdy, Suzanne C.

doi:10.1016/j.clinph.2021.08.023

Cited by 10 publications

(6 citation statements)

References 57 publications

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“…The N400 in PWA has been shown to be not only decreased in amplitude but also delayed ( Meechan et al, 2021 ). Therefore, we analyzed latency differences using the fractional area latency method ( Kiesel et al, 2008 , Liesefeld, 2018 ) as recommended by Sassenhagen & Draschkow (2019) .…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, it has been recognized that deficits in language comprehension in people with aphasia (PWA) do not only arise at the lexical or syntactic level but may also impair the integration of meaning across individual words. In this vein, research on the electrophysiological correlates of aphasic language processing has shown that the event-related-potential (ERP) component N400, related to the lexico-semantic processing of an utterance, is diminished and/or delayed as compared to age-matched controls ( Chang et al, 2016 , Kawohl et al, 2010 , Khachatryan et al, 2017 , Sheppard et al, 2017 , Swaab et al, 1997 ), for a review see Meechan et al (2021) . Notably, the N400 amplitude in response to a highly implausible last word of a sentence has been shown to be decreased with increasing aphasia severity ( Chang et al, 2016 , Kawohl et al, 2010 , Swaab et al, 1997 , Hagoort et al, 1996 ).…”

Section: Introductionmentioning

confidence: 99%

“…Several electrophysiological ‘biomarkers’ have been shown to differentiate between PWA and neurotypical controls and to correlate with aphasia severity. Despite the ongoing debate about the functional interpretation of the P600 (as discussed above), there is general agreement that both the N400 and P600 are strongly related to language processing and are therefore prime candidates in the diagnosis and monitoring of aphasia ( Meechan et al, 2021 ). Specifically, the reduced and delayed N400 effect may serve as a potential diagnostic tool for aphasia.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Electrophysiological correlates of basic semantic composition in people with aphasia

Graessner,

Duchow,

Zaccarella

et al. 2023

NeuroImage: Clinical

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Electrophysiological correlates of basic semantic composition in people with aphasia

Graessner,

Duchow,

Zaccarella

et al. 2023

NeuroImage: Clinical

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“…On the one hand, the ERP technique in PWA often reveals reduced amplitudes and increased latencies of the phonemic MMN (Aaltonen et al, 1993; Csépe et al, 2001), phonemic P300 (Aerts et al, 2015) and/or N400 (Meechan et al, 2021), although the results vary depending on multiple variables such as the lesion localisation (Aaltonen et al, 1993; Ehlers et al, 2015; Friederici et al, 1998). In addition, correlations have been shown between the severity of language disorders and the size of amplitude reductions.…”

Section: Introductionmentioning

confidence: 99%

Test–retest reliability of electroencephalographic and magnetoencephalographic measures elicited during language tasks: A literature review

Cocquyt

Laeken

Mierlo

et al. 2023

Eur J of Neuroscience

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Electroencephalographic (EEG) and magnetoencephalographic (MEG) recordings during language processing can provide relevant insights on neuroplasticity in clinical populations (including patients with aphasia). To use EEG and MEG in a longitudinal way, the outcome measures should be consistent across time in healthy individuals. Therefore, the current study provides a review on the test–retest reliability of EEG and MEG measures elicited during language paradigms in healthy adults. PubMed, Web of Science and Embase were searched for relevant articles based on specific eligibility criteria. In total, 11 articles were included in this literature review. The test–retest reliability of the P1, N1 and P2 is systematically considered to be satisfactory, whereas findings are more variable for event‐related potentials/fields occurring later in time. The within subject consistency of EEG and MEG measures during language processing can be influenced by multiple variables such as the stimulus presentation mode, the offline reference choice and the required amount of cognitive resources during the task. To conclude, most of the available results are favourable regarding the longitudinal use of EEG and MEG measures elicited during language paradigms in healthy young individuals. In view to the use of these techniques in patients with aphasia, future research should focus on whether the same findings apply to different age groups.

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“…For example, in the domain of acquired language disorder (i.e., aphasia) due to stroke, when comparing the stroke group with a stroke-free group, it has been found that ERP components tend to have smaller amplitudes over the scalp and unusual scalp distributions. Moreover, studies have also found that aspects of ERP components (e.g., amplitude and topography) are correlated with the severity of the stroke and the corresponding impairment (for reviews e.g., Ehlers et al, 2015; Meechan et al, 2021; Silkes & Anjum, 2021; Vatinno et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

The impact of CSF-filled cavities on scalp EEG and its implications

Piai,

Oostenveld,

Schoffelen

et al. 2023

Preprint

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Previous studies have found EEG amplitude and scalp topography differences between neurotypical and neurological/neurosurgical groups, being interpreted at the cognitive level. However, these comparisons are invariably accompanied by anatomical changes. Critical to EEG are the so-called volume currents, which are affected by the spatial distribution of the different tissues in the head. We investigated the effect of CSF-filled cavities on simulated EEG scalp data. We simulated EEG scalp potentials for known sources using different volume conduction models: a reference model (i.e., unlesioned brain) and models with realistic CSF-filled cavities gradually increasing in size. We used this approach for a single source close or far from the CSF-lesion cavity, and for a scenario with a distributed configuration of sources (i.e., a “cognitive ERP effect”). Magnitude and topography error between the reference and lesion models were quantified. For the single-source simulation close to the lesion, the CSF-filled lesion modulated signal amplitude with more than 17% magnitude error, and topography with more than 9% topographical error. Negligible modulation was found for the single source far from the lesion. For the multi-source simulations of the cognitive effect, the CSF-filled lesion modulated signal amplitude with more than 6% magnitude error, and topography with more than 16% topography error in a non-monotonic fashion. In conclusion, the impact of a CSF-filled cavity cannot be neglected for scalp-level EEG data. Especially when group-level comparisons are made, any scalp-level attenuated, aberrant, or absent effects are difficult to interpret without considering the confounding effect of CSF.Impact statementPrevious studies have found EEG amplitude and scalp topography differences between neurotypical and neurological/neurosurgical groups (whose brain damage leads to the presence of a CSF-filled cavity), being interpreted at the cognitive level. Via simulations of scalp-level EEG patterns, we show that attenuated, aberrant, or absent effects in these comparisons are difficult to interpret without considering the confounding effect of CSF.FundingThis study was partly supported by grants from the Netherlands Organization for Scientific Research (Nederlandse Organisatie voor Wetenschappelijk Onderzoek [NWO]) to V. P. (451-17-003 and VI.Vidi.201.081) and to the Language in Interaction Consortium (024-001-006).CRediTVP:Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editingRO:Conceptualization, Methodology, Software, Writing – review & editingJMS:Conceptualization, Methodology, Software, Writing – review & editingMCP:Conceptualization, Investigation, Methodology, Visualization, Writing – review & editing

show abstract

The electrophysiology of aphasia: A scoping review

Cited by 10 publications

References 57 publications

Electrophysiological correlates of basic semantic composition in people with aphasia

Electrophysiological correlates of basic semantic composition in people with aphasia

Test–retest reliability of electroencephalographic and magnetoencephalographic measures elicited during language tasks: A literature review

The impact of CSF-filled cavities on scalp EEG and its implications

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