The electroencephalogram in Parkinson's syndrome

England, Albert C.; Schwab, Robert S.; Peterson, Elizabeth

doi:10.1016/0013-4694(59)90111-7

Cited by 58 publications

(30 citation statements)

References 6 publications

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“…Thus, in the case of Parkinsonism, in which low-frequency activity was reported (32)(33)(34), excess inhibition, produced by hyperactive pallidal input onto the motor thalamus, produces hyperpolarization of thalamic relay cells, with the consecutive de-inactivation of T-channels (35) and the appearance of low-threshold calcium spiking and low-frequency oscillation (36)(37)(38). This oscillation produces then the edge effect, which generates the clinical Parkinsonian manifestations (32).…”

Section: Discussionmentioning

confidence: 99%

Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography

Llinás

Ribary

Jeanmonod

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

1,213

1,093

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Spontaneous magnetoencephalographic activity was recorded in awake, healthy human controls and in patients suffering from neurogenic pain, tinnitus, Parkinson's disease, or depression. Compared with controls, patients showed increased low-frequency rhythmicity, in conjunction with a widespread and marked increase of coherence among high-and low-frequency oscillations. These data indicate the presence of a thalamocortical dysrhythmia, which we propose is responsible for all the above mentioned conditions. This coherent activity, the result of a resonant interaction between thalamus and cortex, is due to the generation of lowthreshold calcium spike bursts by thalamic cells. The presence of these bursts is directly related to thalamic cell hyperpolarization, brought about by either excess inhibition or disfacilitation. The emergence of positive clinical symptoms is viewed as resulting from ectopic ␥-band activation, which we refer to as the ''edge effect.'' This effect is observable as increased coherence between low-and high-frequency oscillations, probably resulting from inhibitory asymmetry between high-and low-frequency thalamocortical modules at the cortical level.edge effect ͉ activity ͉ ␥ activity ͉ humans

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Section: Discussionmentioning

confidence: 99%

Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography

Llinás

Ribary

Jeanmonod

et al. 1999

Proc. Natl. Acad. Sci. U.S.A.

1,213

1,093

View full text Add to dashboard Cite

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“…As anormalidades eletrencefalográficas na doença de Parkinson (DP) consistem de alterações difusas e não específicas, como a lentificação dos ritmos de fundo posteriormente e aumento na atividade teta e delta 6,19 . Os mesmos achados foram recentemente demonstrados através de análise espectral 20 .…”

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Eletrencefalograma digital com mapeamento em demência de Alzheimer e doença de Parkinson: estudo prospectivo controlado

Sandmann

Piana

Sousa

et al. 1996

Arq. Neuro-Psiquiatr.

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RESUMO -Com o intuito de estudar a atividade eletrencefalográfica em vigilia da demência senil de tipo Alzheimer (DA) e da doença de Parkinson (DP) foi iniciado estudo prospectivo e controlado. Foram comparados 6 pacientes com DA e 11 pacientes com DP, com um grupo controle composto por 12 pacientes com depressão maior crônica leve a moderada (DSM-III-R, 1987). Nos três grupos, através de análise espectral, foi obtida a mediana da frequência da energia da atividade dominante posterior. O grupo controle apresentou atividade posterior com frequência de 8,79 ± 0,52 (m±dp). No grupo com DA este valor foi 6,65 ± 0,80 (m±dp) e no grupo com DP 7,69± 1,39 (m±dp). A hipótese experimental de que pacientes com DA e DP diferem dos controles em relação à atividade de fundo (definida como anormal sendo <8) foi confirmada pelo teste do qui quadrado (p=0,01) e no teste t a média das frequências da energia posterior foi significativamente menor nos pacientes com DA (p=0,01) e DP (p=0,05) do que nos controles. Os resultados indicam que esta anormalidade possa ser correlacionada com o grau de comprometimento cortical e a gravidade da evolução da DA e da DP. PALAVRAS-CHAVE: eletrencefalografia, mapeamento cerebral, demências, doença de Parkinson, doença de Alzheimer, depressão.Serviços de Neurologia e Eletroencefalografia do Hospital Nossa Senhora das Graças, Curitiba: * Neurologista e Fellow em Epileptologia e Eletroencefalografia, ** Residente do Serviço de Neurologia; *** Residente do Serviço de Neurocirurgia, **** Chefe dos Serviços de Neurologia e Eletroencefalografia. Aceite: l7-novembro-l995.Dr. Paulo Rogério M. de Bittencourt -Unidade de Neurologia Clínica S/C Ltda -Rua Padre Anchieta 155 -80410-030 Curitiba PR -Brasil. Digital EEG with brain mapping in Alzheimer's dementia and Parkinson's disease: a prospective controlled studyABSTRACT -In order to evaluate the EEG activity during wakefulness in senile dementia of the Alzheimer type (AD) and Parkinson's disease (PD), a prospective controlled study was performed. We compared 6 AD and 11 PD patients with a control group of 12 patients with mild to moderate major chronic depression (DSM-III-R 1987). The median of the frequencies and the power of the posterior dominant activity was obtained in the three groups using spectral analysis. The posterior activity had a frequency of 8.79±0.52 (mean±sd) in the contrc group, 6.65+0.80 (mean+sd) in the AD group and 7.69+1.39 (mean±sd) in the PD group. The experimenta] hypothesis that patients with AD and PD differ from controls in relation to the background activity (defined a abnormal <8) was confirmed by the chi square test (p=0.0l) and the t test showed that the mean of the frequency of the posterior power was significantly lower in AD (p=0.01) and PD (p=0.05) patients, compared with the controls. The results indicate that this abnormality could be correlated with the degree of cortical damage and natural history of these disorders.

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“…EEG studies in Parkinson's disease (PD) have shown that while the EEG is not consistently affected, (he preva lence of abnormalities is greater than in the normal popu lation (1], Cognitive disturbances in patients with PD are at least twice as common as expected in this age group [2, .3], Abnormal EEG records were observed particularly in demented PD patients and in those with increased motor disability consisting mainly of diffuse or local nonspecific slowing [4,5]. Because motor function and cognition fre quently deteriorate in parallel, it is often difficult to dis tinguish whether the EEG changes are related to demen tia, or to motor decline (and thus may be related to impairment in subcortical structures) [5,6].…”

Section: Introductionmentioning

confidence: 99%

EEG Frequency Analysis in Demented and Nondemented Parkinsonian Patients

Neufeld

Blumen

Aitkin

et al. 1994

Dement Geriatr Cogn Disord

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In an attempt to evaluate EEG changes associated with dementia in Parkinson''s disease (PD), we performed frequency analysis in three groups of 10 subjects each; two with PD, and one normal control group. The PD patient groups were matched for age, sex, severity and duration of disease, but were discordant for the existence of dementia. Normals were age- and sex-matched healthy volunteers. The relative alpha amplitude was significantly decreased in the demented PD patients, unrelated to motor disability. There was a non-significant but consistent trend of increased amplitude in the delta and theta range in the demented PD patients as compared to nondemented PD subjects and normal controls, as well as increased amplitude in the theta and delta range with more severe motor disability in the nondemented PD patients.

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The electroencephalogram in Parkinson's syndrome

Cited by 58 publications

References 6 publications

Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography

Thalamocortical dysrhythmia: A neurological and neuropsychiatric syndrome characterized by magnetoencephalography

Eletrencefalograma digital com mapeamento em demência de Alzheimer e doença de Parkinson: estudo prospectivo controlado

EEG Frequency Analysis in Demented and Nondemented Parkinsonian Patients

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