The electroencephalogram in hepato-lenticular degeneration (Wilson's disease)

Comparison of MRI, EEG, EPs and ECD-SPECT in Wilson's disease

“…Electroencephalographic changes are found in patients suffering from HLD (19–22) and particu‐larly in those with more severe neurologic symptoms (21, 23–26). In most cases, however, these changes are slight or moderate (20, 21, 27), aspecific, and polymorphous (21, 28).…”

“…In some cases an activity unstable by frequency and amplitude with bursts of hypersynchronous rhythms has been described (27). Slow focal activity, generalized slow activity, bursts of slow waves, at times bisynchronous, and the appearance of spikes and sharp‐waves, spike‐and‐waves, sharp and slow waves, triphasic waves, mu rhythm (19, 20, 22, 24–26, 28–36) and background asymmetries (26) have also been described. The largest EEG changes were more frequent in younger patients (20) and in those with white matter involvement, akinesia, dystonia or psychiatric symptoms (22).…”