The electrochemiluminescence coreactant accelerator of metal–organic frameworks grafted with <i>N</i>-(aminobutyl)-<i>N</i>-(ethylisoluminol) for the ultrasensitive detection of chloramphenicol

Wang, Xintao; Jiang, Yifan; Gu, Yixin; Huang, Xiaoqin; Wang, Ai‐Jun; Yuan, Pei-Xin; Feng, Jiu‐Ju

doi:10.1039/d1an01077h

Cited by 10 publications

(6 citation statements)

References 57 publications

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“…To explore the optical properties of Tr-HOFs, the UV–vis spectrum was first provided (Figure A). In brief, there is a classical absorbance inflection point located at 376 nm for the conjugated aggregation structure (curve a) . Nevertheless, the inflection point is centered at 353 nm for the phenyDAT molecule (curve b), indicating its unstable energy level state in dimethyl sulfoxide (DMSO) solution.…”

Section: Resultsmentioning

confidence: 99%

Hydrogen Bond Organic Frameworks as a Novel Electrochemiluminescence Luminophore: Simple Synthesis and Ultrasensitive Biosensing

et al. 2021

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Nowadays, continuous efforts have been devoted to searching highly efficient electrochemiluminescence (ECL) emitters for applications in clinical diagnosis and food safety. In this work, triazinyl-based hydrogen bond organic frameworks (Tr-HOFs) were synthesized by N···H hydrogen bond self-assembly aggregation, where 6,6′-(1,4-phenylene)bis(1,3,5-triazine-2,4-diamine) (phenyDAT) was prepared via the cyclization reaction and behaved as a novel ligand. Impressively, the resulting Tr-HOFs showed strong ECL responses with highly enhanced ECL efficiency (21.3%) relative to the Ru(bpy)3 2+ standard, while phenyDAT hardly showed any ECL emission in aqueous phase. The Tr-HOFs innovatively worked as a new ECL luminophore to construct a label-free biosensor for assay of kanamycin (Kana). Specifically, the ECL response greatly weakened upon assembly of captured DNA with ferrocene (cDNA-Fc) onto the Tr-HOFs-modified electrode, while the ECL signals were adversely recovered by releasing linked DNA (L-DNA) from double-stranded DNA (dsDNA, hybridization of aptamer DNA (aptDNA) with L-DNA) due to the specific recognition of Kana with the aptDNA combined by the linkage of L-DNA and cDNA-Fc on the electrode. The as-built sensor showed a broadened linear range (1 nM–10 μM) and a limit of detection (LOD) down to 0.28 nM, which also displayed satisfactory results in the analysis of Kana in the milk and diluted human serum samples. This work offers a novel pathway to design an ECL emitter with organic molecules, holding great promise in biomedical analysis and food detection.

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Section: Resultsmentioning

confidence: 99%

Hydrogen Bond Organic Frameworks as a Novel Electrochemiluminescence Luminophore: Simple Synthesis and Ultrasensitive Biosensing

et al. 2021

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“…According to previous research, the ECL reaction of ABEI with TPA follows the “oxidative-reductive” route, where TPA oxidation is the key step. The ECL equations are described as follows: 23,38 ABEI – e − → ABEI + (at 0.47 V)TPA – e − → TPA˙ + (at 0.79 V)TPA˙ + – H + → TPA˙ABEI + + TPA˙ → ABEI* + P 1 ABEI* → ABEI + ℏ v (at 463 nm)…”

Section: Resultsmentioning

confidence: 99%

“…According to previous research, the ECL reaction of ABEI with TPA follows the "oxidative-reductive" route, where TPA oxidation is the key step. The ECL equations are described as follows: 23,38 ABEI -e − / ABEI + (at 0.47 V)…”

Section: The Ecl Enhanced Mechanism Of Abei-cofs In the Tpa Systemmentioning

confidence: 99%

“…22 Also, Zn-based metal–organic frameworks (MOFs) greatly accelerated the electrocatalytic oxidation of tripropylamine (TPA), followed by 18-fold enhancement in the ECL intensity over ABEI itself. 23 Even though luminol and its derivatives have distinctly efficient ECL responses, their environmentally-unfriendly characteristics and complicated synthesis seriously restrict their further applications in the bioanalytical field.…”

Section: Introductionmentioning

confidence: 99%

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Covalent organic framework linked with amination luminol derivative as enhanced ECL luminophore for ultrasensitive analysis of cytochromec

et al. 2022

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“…Also, the peak current (i p ) is well proportionated to the square root of the scan rate (v 1/2 ) with a slope of 1.63 μA (mV s −1 ) −1/2 (Figure 4A, curve a), exhibiting a typical "diffusion-controlled" process for this reaction. 41 What's more, the slope value increases 5.43 times that of bare ITO (Figure 4A, curve b, 0.30 μA (mV s −1 ) −1/2 ), reflecting that the HOFs largely accelerate the oxidation of H 2 O 2 in this research.…”

Section: Morphological and Structural Characterization Ofmentioning

confidence: 99%

Hydrogen Bond Organic Frameworks as Radical Reactors for Enhancement in ECL Efficiency and Their Ultrasensitive Biosensing

et al. 2023

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Nowadays, electrochemiluminescence (ECL) efficiency of an organic emitter is closely related with its potential applications in food safety and environmental monitoring fields. In this work, 2,4,6-tris(4-carboxyphenyl)-1,3,5-triazine (TATB) was self-assembled to form hydrogen bond organic frameworks (HOFs), which worked as ideal reactors to generate highly active oxygen-containing radicals, followed by linking with isoluminol (ILu) via amide bond (termed ILu-HOFs). After covalent assembly with aminated indium−tin oxide electrode (labeled NH 2 -ITO), the ECL efficiency of the ILu-HOFs NH 2 -ITO showed about a 23.4time increase over that of ILu itself in the presence of H 2 O 2 . Meanwhile, the enhanced ECL mechanism was mainly studied by electron paramagnetic resonance, theoretical calculation, and electrochemistry. On the above foundation, an aptamer "sandwich" ECL biosensor was constructed for detecting isocarbophos (ICP) via in situ elimination of H 2 O 2 with catalase-linked palladium nanocubes (CAT-Pd NCs). The as-built sensor showed a broad linear range (1 pM to 100 nM) and a low limit of detection (LOD) down to 0.4 pM, coupled with efficient assays of ICP in lake water and cucumber juice samples. This strategy provides an effective way for the synthesis of advanced ECL emitter, coupled by showing promising applications in environmental and food analysis.

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The electrochemiluminescence coreactant accelerator of metal–organic frameworks grafted with N-(aminobutyl)-N-(ethylisoluminol) for the ultrasensitive detection of chloramphenicol

Abstract: In this work, metal organic frameworks (MOFs) are utilized as effective ECL coreactant accelerator to enhance the ECL responses of N-(aminobutyl)-N-(ethylisoluminol) (ABEI). The Zn-based MOFs (MOF-Zn-1) was prepared by chelating...

Cited by 10 publications

References 57 publications

Hydrogen Bond Organic Frameworks as a Novel Electrochemiluminescence Luminophore: Simple Synthesis and Ultrasensitive Biosensing

Hydrogen Bond Organic Frameworks as a Novel Electrochemiluminescence Luminophore: Simple Synthesis and Ultrasensitive Biosensing

Covalent organic framework linked with amination luminol derivative as enhanced ECL luminophore for ultrasensitive analysis of cytochromec

Hydrogen Bond Organic Frameworks as Radical Reactors for Enhancement in ECL Efficiency and Their Ultrasensitive Biosensing

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