The electrochemically enabled α-C(sp³)–H azolation of ketones

Abstract

We herein reported an electrochemical synthesis of α-tetrazolyl ketones by C–H/N–H cross-coupling with excellent yields and broad substrate scope, encompassing various aryl ketones, heterocycles, and alkyl ketone drugs.

Electrochemical Oxidative Cross-Coupling Reactions of Ketene Dithioacetals and Dichalcogenides to Construct C−Se/C−S Bonds

“…In recent years, electrochemical organic transformations have emerged as an attractive and suitable approach, which has attracted the attention of research groups. [34][35][36][37][38][39][40] With untraceable and inexpensive electrons as the redox reagents, construction of C−Se/C−S bonds by electrochemical oxidative cross-coupling reactions offered new possibilities for green organic synthesis. [41][42][43][44][45][46] In 2021, Wang and co-workers developed a strategy for H 2 O-controlled thiocyanation by electrochemical oxidation to construct C−S bonds from ketene dithioacetals and potassium thiocyanate (KSCN).…”