The Electrocatalytic Detection of Nitrite Using Manganese Schiff Base Phthalocyanine Complexes

Ndebele, Nobuhle; Nyokong, Tebello

doi:10.1007/s12678-022-00752-4

Cited by 4 publications

(2 citation statements)

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“…The chemical properties of the side groups in substituted phthalocyanines significantly influence the properties of Pcs, such as electronic absorption, solubility, aggregation, and usability in application areas 17 . Schiff bases attached to phthalocyanine complexes have found application in different research fields because of their excellent physicochemical, biological, catalytic, and electrochemical properties 18–23 …”

Section: Introductionmentioning

confidence: 99%

“…17 Schiff bases attached to phthalocyanine complexes have found application in different research fields because of their excellent physicochemical, biological, catalytic, and electrochemical properties. [18][19][20][21][22][23] This study focuses on the design, synthesis, and characterization of six phthalocyanine complexes for biochemical assays. The peripheral aldehyde-substituted metallophthalocyanines in this study were synthesized from aldehyde-bearing phthalonitrile (a).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes activity of aldehyde and Schiff base substituted cobalt (II), copper (II), and zinc (II) phthalocyanines

Yalazan,

Kamiloglu,

Tekin

et al. 2024

Applied Organom Chemis

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In this work, a series of aldehyde‐substituted phthalocyanine compounds (1, 3, and 5) were prepared by the cyclotetramerization of the 4‐(5‐(diethylamino)‐2‐formylphenoxy) phthalonitrile (a) and the corresponding metal salts. Schiff base‐substituted phthalocyanines (2, 4, and 6) were derived from an aldehyde‐substituted phthalocyanine (1, 3, and 5) via the reaction of aldehyde‐substituted phthalocyanines with an amine reagent. The compounds that were obtained were characterized using FT‐IR, 1H {13C} NMR, UV–Vis, and MS spectra (a and 1–6). The inhibitory qualities of synthesized aldehyde and Schiff base‐substituted complexes against the enzymes butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) were assessed. The majority of phthalocyanines exhibited strong enzyme‐inhibiting properties. Out of the six produced phthalocyanines, 3 and 4 displayed the most intriguing profiles as submicromolar selective AChE inhibitors (IC50 = 0.060 μM), whereas 1 demonstrated the most potent BChE inhibitor (IC50 = 0.024 μM). The aggregation studies of CoPcs, CuPcs, and ZnPcs (1–6) were also carried out in this work.

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Section: Introductionmentioning

confidence: 99%