The electrical basis of excitation and inhibition in the rat anoccygeus muscle.

Creed, Kate E.; Gillespie, John; Muir, T. C.

doi:10.1113/jphysiol.1975.sp010833

Cited by 56 publications

(59 citation statements)

References 16 publications

(11 reference statements)

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“…Using electrophysiological recording techniques, it has been shown that transmural nerve stimulation evokes a noradrenergic excitatory junction potential (EJP) which has a latency of several hundred milliseconds and a duration of about 1 s (Creed et al 1975). EJPs were abolished by guanethidine and by á_adrenoceptor antagonists indicating that they result from sympathetic nerve stimulation and involve the activation of á_adrenoceptors (Creed et al 1975;Large, 1982). The noradrenergic EJPs evoked by sympathetic nerve stimulation can be mimicked by the ionophoretic application of noradrenaline (Large, 1982).…”

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confidence: 99%

Sympathetic neuroeffector transmission in the rat anococcygeus muscle

Bramich

Hirst

1999

The Journal of Physiology

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1. When intracellular recordings were made from preparations of rat anococcygeus muscle, transmural nerve stimulation evoked noradrenergic excitatory junction potentials (EJPs) made up of two distinct components. Both components were abolished by either guanethidine or á_adrenoceptor antagonists, indicating that they resulted from the release of transmitter from sympathetic nerves and the subsequent activation of á_adrenoceptors. produced by an increasing number of sympathetic nerve stimuli were determined in control, and caffeine-and nifedipine-containing solutions, it was found that an increase in [Ca¥]é recorded in nifedipine produced a larger contraction and larger membrane depolarization than did a similar increase in [Ca¥]é recorded in either control or caffeine-containing solutions. These observations indicate that Ca¥ released from stores more readily triggers contraction and membrane depolarization than does Ca¥ entry via CaL channels.8905

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confidence: 99%

Sympathetic neuroeffector transmission in the rat anococcygeus muscle

Bramich

Hirst

1999

The Journal of Physiology

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“…There is, therefore, no evidence to deny the proposal (Byrne & Large, 1984) that the smaller, slow depolarization, the most common response to single stimuli, arises from the asynchronous release of transmitter while the faster, larger ej.ps are the product of a synchronized release of transmitter following trains of stimuli. As previously shown in the field stimulated preparation (Creed et al, 1975), both membrane depolarizations were susceptible to a-adrenoceptor blockade.…”

Section: Discussionmentioning

confidence: 49%

“…The fast ej.ps always preceded the onset of contraction. The rates of rise of the slow depolarization and the fast ej.ps (Creed et al, 1975) varied with frequency and stimulus strengths. This probably reflects facilitation of transmitter release, a feature characteristic of this muscle (Creed et al, 1975).…”

Section: Resultsmentioning

confidence: 99%

“…The rates of rise of the slow depolarization and the fast ej.ps (Creed et al, 1975) varied with frequency and stimulus strengths. This probably reflects facilitation of transmitter release, a feature characteristic of this muscle (Creed et al, 1975). The mean ± s.e.mean rate of rise of the slow depolarizations measured under identical parameters of stimulation (1 pulse 0.2 ms, 20 V) was 0.6 ± 0.1 mV s-' (n = 12).…”

Section: Resultsmentioning

confidence: 99%

“…There remains the possibility, however, that these drugs could, in addition to their purinoceptor blocking effects, interfere with a-adrenoceptors, transmitter release or the ability of the postsynaptic membrane to generate ej.ps. Indeed, a lack of specificity has been proposed and the suggestion made that, a, P-MeATP may abolish ej.ps irrespective of whether they are produced by neuronally-released ATP or NA (Byrne & Large, 1986 (Creed et al, 1975 …”

Section: Introductionmentioning

confidence: 99%

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Is co‐transmission involved in the excitatory responses of the rat anococcygeus muscle?

Cunnane

Muir

Wardle

1987

British J Pharmacology

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Electrical and mechanical responses to field (transmural) and extrinsic nerve stimulation were recorded simultaneously in the rat anococcygeus muscle. Membrane potential changes recorded intracellularly following either method of stimulation were indistinguishable. Single stimuli usually produced a slow depolarization; trains of pulses produced a fast excitatory junction potential (e.j.p.) initially, followed by a slow depolarization similar to that produced by single pulses. The fast e.j.ps, the slow depolarizations and the accompanying contractions were abolished by the α‐adrenoceptor antagonists, phentolamine (1 × 10−6 m) or prazosin (1 × 10−7 m) and by tetrodotoxin (TTX, 1 × 10−6 m) but unaffected by α, β‐methylene adenosine triphosphate (α, β‐MeATP, 1–10 × 10−6 m), an agent known to desensitize purinoceptors. Application of noradrenaline (NA, 1 × 10−8‐1 × 10−6 m), by pressure ejection from a micropipette, depolarized the membrane and produced a localized contraction, both of which were abolished by phentolamine (1 × 10−6 m) or prazosin (1 × 10−7 m). Application of adenosine‐5′‐triphosphate (ATP, 1 × 10−4‐1 × 10−3 m), by pressure ejection from a micropipette, produced a small membrane depolarization and localized contraction which were unaffected by phentolamine (1 × 10−6 m) or prazosin (1 × 10−7 m) but abolished by α, β‐MeATP (1 × 10−6 m). The results show that, in the rat annococcygeus muscle, (1) field or extrinsic nerve stimulation released only one excitatory transmitter, namely NA, although receptors for both NA and ATP were present on the muscle, (2) α, β‐MeATP was selective for purinoceptors and (3) there was no evidence for excitatory co‐transmission in this tissue.

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The Nitrergic Transmitter of the Anococcygeus: Lessons and Insights

Gibson¹

2000

Nitric Oxide and Free Radicals in Peripheral Neurotransmission

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The electrical basis of excitation and inhibition in the rat anoccygeus muscle.

Cited by 56 publications

References 16 publications

Sympathetic neuroeffector transmission in the rat anococcygeus muscle

Sympathetic neuroeffector transmission in the rat anococcygeus muscle

Is co‐transmission involved in the excitatory responses of the rat anococcygeus muscle?

The Nitrergic Transmitter of the Anococcygeus: Lessons and Insights

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