The Election of Dr. J. A. Macdonald as a Direct Representative.

MacDonald, James

doi:10.1016/s0140-6736(01)53338-3

Cited by 2 publications

(2 citation statements)

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“…42 Affymetrix probe set identifiers were annotated using the BioConductor package AnnotationDbi (v1.38.1) 43 with the mogene20sttranscriptcluster database (v8.6.0). 44 Differential expression between control and resuscitated samples was tested using per-gene linear models and an empirical Bayes estimation of expression variances, as implemented in the BioConductor package limma (v3.32.2). 45 P-values were adjusted for multiple testing by applying the Benjamini & Hochberg false discovery rate (FDR) method.…”

Section: Expression Analysesmentioning

confidence: 99%

Biological events and molecular signaling following MLKL activation during necroptosis

et al. 2017

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Necroptosis is a form of programmed necrotic cell death mediated by the kinase RIPK3 and its substrate MLKL. MLKL, which displays plasma membrane (PM) pore-forming activity upon phosphorylation, functions as the executioner during necroptosis. Thus, it was previously assumed that MLKL phosphorylation is the endpoint of the necroptotic signaling pathway. Here, we summarize several events that characterize the dying necroptotic cells after MLKL phosphorylation, including Ca influx, phosphatidylserine (PS) externalization, PM repair by ESCRT-III activation, and the final compromise of PM integrity. These processes add several unexpected regulatory events downstream of MLKL signaling. We have also observed that CoCl, which may mimic hypoxia, can induce necroptosis, which suggests that in vivo triggers of necroptosis might include a transient lack of O.

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Section: Expression Analysesmentioning

confidence: 99%

Biological events and molecular signaling following MLKL activation during necroptosis

et al. 2017

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“…By the time of isolation, the wild-type hyphae developing from the terminally responding puffs were forming morphologically normal clamp connections, and they continued to do so after transfer to fruiting medium. The clamps were expected, since the pairings involved fully compatible combinations for mating type (see RAPER and MILES 1958, for details) and should form dikaryotic mycelia after the transport of nuclei, irrespective of the means of transport. Tests for normal meiosis were made with most of the isolates.…”

Section: Resultsmentioning

confidence: 99%

Genetic Evidence for Nuclear Migration in Basidiomycetes

Snider

1963

Genetics

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N various fungi genetically marked nuclei implanted in a mycelium can be Irecovered centimeters from the point of implantation after an interval of hours or days. The transport of such nuclei (or their mitotic progeny) could occur by the dispersal of spores, by the intrusive growth of new hyphae, by the migration of whole nuclei through pre-existing hyphae, or by other means. In fact, such transport may occur by a variety of mechanisms in the same fungus.Although the idea of nuclear migration in fungi has become widespread, PAPAZIAN (1958, pp. 44-45) has questioned the absolute validity of the evidence for migration in Basidiomycetes, and even in a recent article about migration, SWIEZYNSKI (1961) evaluates the evidence with the guarded comment that "The alternative hypothesis . . . is difficult to accept for various reasons.'' The original report of nuclear translocation by migration in fungi (BULLER 1931) involved Coprinus Zagopus (Basidiomycetes) and was based upon: ( 1 ) kinetic data indicating the rate of nuclear migration is faster than the rate of hyphal-tip g r o~h (p. 217), and (2) genetic data involving the detection and recovery of migrating nuclei from preexisting, partially isolated hyphae (pp. 234-241). More recent studies of nuclear migration, including those of FULTON ( 1950FULTON ( , 1951 , KIMURA

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The Election of Dr. J. A. Macdonald as a Direct Representative.

Cited by 2 publications

References 0 publications

Biological events and molecular signaling following MLKL activation during necroptosis

Biological events and molecular signaling following MLKL activation during necroptosis

Genetic Evidence for Nuclear Migration in Basidiomycetes

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