The ELAN-ONCOVAL (ELderly heAd and Neck cancer-Oncology eValuation) study: Evaluation of the feasibility of a suited geriatric assessment for use by oncologists to classify patients as fit or unfit

Mertens, C.; Caer, H. Le; Ortholan, C.; Blot, Emmanuel; Even, Caroline; Rousselot, Hubert; Peyrade, Fréd́eric; Siré, C.; Cupissol, Didier; Pointreau, Y.; Debourdeau, Philippe; Rolland, Frédéric; Fayette, Jérôme; Capitain, Olivier; Sun, Xu-Shan; Debbah, M.; Schwob, Dominique; Boulahssass, Rabia; Aupérin, Anne; Guigay, J.

doi:10.1093/annonc/mdx374.007

Cited by 14 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical expertise in HNC within OncoAge is highlighted by the ELAN (ELderly Head and Neck cancer) program. These clinical studies on curative or palliative personalized treatment of elderly head and neck cancer patients after geriatric assessment (Elan Geriatric Evaluation, EGE) currently represent the only multi-center therapeutic trials dedicated to this group of patients worldwide [34,35,36]. Studies were completed in 2018 and results will be presented in 2019.…”

Section: Oncoage: Main Results After Three Years Of Existence (201mentioning

confidence: 99%

The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again

Hofman

Ayache

Barbry

et al. 2019

Cancers

View full text Add to dashboard Cite

It is generally accepted that carcinogenesis and aging are two biological processes, which are known to be associated. Notably, the frequency of certain cancers (including lung cancer), increases significantly with the age of patients and there is now a wealth of data showing that multiple mechanisms leading to malignant transformation and to aging are interconnected, defining the so-called common biology of aging and cancer. OncoAge, a consortium launched in 2015, brings together the multidisciplinary expertise of leading public hospital services and academic laboratories to foster the transfer of scientific knowledge rapidly acquired in the fields of cancer biology and aging into innovative medical practice and silver economy development. This is achieved through the development of shared technical platforms (for research on genome stability, (epi)genetics, biobanking, immunology, metabolism, and artificial intelligence), clinical research projects, clinical trials, and education. OncoAge focuses mainly on two pilot pathologies, which benefit from the expertise of several members, namely lung and head and neck cancers. This review outlines the broad strategic directions and key advances of OncoAge and summarizes some of the issues faced by this consortium, as well as the short- and long-term perspectives.

show abstract

Section: Oncoage: Main Results After Three Years Of Existence (201mentioning

confidence: 99%

The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again

Hofman

Ayache

Barbry

et al. 2019

Cancers

View full text Add to dashboard Cite

show abstract

“…That is why a CGA by an onco-geriatrician should be part of the HNC MDT (116). Recently, the ELAN-ONCOVAL (Elderly head and Neck Cancer-Oncology eValuation) study evaluating the use of a suited geriatric evaluation to stratify patients and guide therapy in patients ≤70 years old not amenable to surgery showed that, despite the initially planned treatment was changed only in 8% of the cases after a geriatric assessment, the number of patients requiring multidisciplinary interventions was significantly higher when the assessment was performed by geriatrician (71 vs. 51%) (117). The results of this study highlight the relevance of incorporating the onco-geriatrician in the decision making process for the elderly.…”

Section: The Role Of the Onco-geriatricianmentioning

confidence: 99%

The Multidisciplinary Team (MDT) Approach and Quality of Care

et al. 2020

View full text Add to dashboard Cite

The core function of a multidisciplinary team (MDT) is to bring together a group of healthcare professionals from different fields in order to determine patients' treatment plan. Most of head and neck cancer (HNC) units are currently led by MDTs that at least include ENT and maxillofacial surgeons, radiation and medical oncologists. HNC often compromise relevant structures of the upper aerodigestive tract involving functions such as speech, swallowing and breathing, among others. The impairment of these functions can significantly impact patients' quality of life and psychosocial status, and highlights the crucial role of specialized nurses, dietitians, psycho-oncologists, social workers, and onco-geriatricians, among others. Hence, these professionals should be integrated in HNC MDTs. In addition, involving translational research teams should also be considered, as it will help reducing the existing gap between basic research and the daily clinical practice. The aim of this comprehensive review is to assess the role of the different supportive disciplines integrated in an MDT and how they help providing a better care to HNC patients during diagnosis, treatment and follow up.

show abstract

“…Non-oncologic GA-guided interventions are also common and feasible in daily practice: these include physical therapy referrals, nutritional care, psychiatric and neuropsychological consultations, social support assistance [9,10]. The role of CGA remains controversial, and there is still no validation in the HNSCC setting: preliminary results of a study with CGA in HNSCC patients showed that CGA changed treatment decisions in 8% of patients [11,12], but as of now, there is no evidence it improves results in HNSCC patients. Nevertheless, according to many experts, all patients should undertake the CGA before treatment.…”

Section: The Role Of Geriatric Assessmentmentioning

confidence: 99%

“…G8 includes only eight items: age, decreased oral intake, weight loss in the past 3 months, mobility, neuropsychological problems, BMI, ≥3 medications daily, and self-reported overall health. Nevertheless, the ELAN-ONCOVAL trial, published in 2019, endorsed the use of the EGE (ELAN geriatric evaluation) in lieu of the G8 screening tool, which was considered not appropriate for elderly HNSCC patients [11,12]. In the locally advanced (LA) HNSCC setting, small studies using GA have been conducted.…”

Section: The Role Of Geriatric Assessmentmentioning

confidence: 99%

Head and Neck Squamous Cell Carcinoma in Elderly Patients: Role of Radiotherapy and Chemotherapy

Fasano

D’Onofrio²,

Belfiore

et al. 2022

Cancers

View full text Add to dashboard Cite

Head and neck squamous cell carcinomas (HNSCC) constitute the sixth most common malignancy worldwide, with approximately 25–40% of the diagnosed patients older than 70 years. HNSCC patients are often frail and frequently have multiple comorbidities due to their unhealthy lifestyle, and evidence suggests that older patients may receive less aggressive and suboptimal treatment than younger patients with the same disease status. The aim of this review is to depict and summarize the evidence regarding the different strategies that can be used in the clinical management of elderly HNSCC patients. Key references were derived from a PubMed query. Hand searching and clinicaltrials.gov were also used. This paper contains a narrative report and a critical discussion of clinical approaches in the context of elderly HNSCC.

show abstract

The ELAN-ONCOVAL (ELderly heAd and Neck cancer-Oncology eValuation) study: Evaluation of the feasibility of a suited geriatric assessment for use by oncologists to classify patients as fit or unfit

Cited by 14 publications

References 0 publications

The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again

The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again

The Multidisciplinary Team (MDT) Approach and Quality of Care

Head and Neck Squamous Cell Carcinoma in Elderly Patients: Role of Radiotherapy and Chemotherapy

Contact Info

Product

Resources

About