The elaboration of a critical framework for understanding cancer: the cancer stem cell hypothesis

Hemmings, Chris

doi:10.3109/00313020903488773

Cited by 32 publications

(23 citation statements)

References 50 publications

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“…Most recent studies have highlighted the heterogeneity of ovarian tumors, and the current understanding is that inherently chemoresistant cancer stem cells that are not removed by surgery and survive first-line chemotherapy are able to recreate the tumor and cause disease recurrence (4)(5)(6)(7)(8). Our group and others have demonstrated that within the heterogeneous tumor, CD44…”

Section: Introductionmentioning

confidence: 99%

TRX-E-002-1 Induces c-Jun–Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo

Alvero

Heaton²,

Lima

et al. 2016

Molecular Cancer Therapeutics

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Chemoresistance is a major hurdle in the management of patients with epithelial ovarian cancer and is responsible for its high mortality. Studies have shown that chemoresistance is due to the presence of a subgroup of cancer cells with stemness properties and a high capacity for tumor repair. We have developed a library of super-benzopyran analogues to generate potent compounds that can induce cell death in chemoresistant cancer stem cells.

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Section: Introductionmentioning

confidence: 99%

TRX-E-002-1 Induces c-Jun–Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo

Alvero

Heaton²,

Lima

et al. 2016

Molecular Cancer Therapeutics

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“…Recently, several in vitro and in vivo studies demonstrated that conventional chemotherapy is ineffective against CSCs [28]. For example, OCT-4 had a role in the chemotherapeutic drug resistance in liver cancer cells through a potential OCT-4-AKT-ATP-binding cassette G2 pathway [29].…”

Section: Discussionmentioning

confidence: 99%

Expression of stem-cell markers OCT-4 and CD133: important prognostic factors in papillary renal cell carcinoma

Kim

et al. 2012

Human Pathology

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“…The size of tumorlet was set to be 64 mm 3 (based on typical PET-voxel size) with 6.4 × 10 7 cells, assuming the tumor cell density of 10 6 mm −3 . Only a small subset of cells is known to have stem-cell-like property and 1% of viable cells were assumed to be clonogenic cells in the model [23]. Based on previous work [21], relevant parameter values for head and neck squamous cell carcinoma (HNSCC) were used, including the radiosensitivity of the P -compartment ( α p = 0.382 Gy −1 , α / β = 6.63 Gy).…”

Section: Methodsmentioning

confidence: 99%

Modeling the Relationship between Fluorodeoxyglucose Uptake and Tumor Radioresistance as a Function of the Tumor Microenvironment

Jeong

Deasy

2014

Computational and Mathematical Methods in Medicine

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High fluorodeoxyglucose positron emission tomography (FDG-PET) uptake in tumors has often been correlated with increasing local failure and shorter overall survival, but the radiobiological mechanisms of this uptake are unclear. We explore the relationship between FDG-PET uptake and tumor radioresistance using a mechanistic model that considers cellular status as a function of microenvironmental conditions, including proliferating cells with access to oxygen and glucose, metabolically active cells with access to glucose but not oxygen, and severely hypoxic cells that are starving. However, it is unclear what the precise uptake levels of glucose should be for cells that receive oxygen and glucose versus cells that only receive glucose. Different potential FDG uptake profiles, as a function of the microenvironment, were simulated. Predicted tumor doses for 50% control (TD50) in 2 Gy fractions were estimated for each assumed uptake profile and for various possible cell mixtures. The results support the hypothesis of an increased avidity of FDG for cells in the intermediate stress state (those receiving glucose but not oxygen) compared to well-oxygenated (and proliferating) cells.

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The elaboration of a critical framework for understanding cancer: the cancer stem cell hypothesis

Cited by 32 publications

References 50 publications

TRX-E-002-1 Induces c-Jun–Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo

TRX-E-002-1 Induces c-Jun–Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo

Expression of stem-cell markers OCT-4 and CD133: important prognostic factors in papillary renal cell carcinoma

Modeling the Relationship between Fluorodeoxyglucose Uptake and Tumor Radioresistance as a Function of the Tumor Microenvironment

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