The Efficacy of Tripterygium Glycosides Combined with LMWH in Treatment of HSPN in Children

Abstract

Objective. This study aimed to explore the clinical efficacy and relevant mechanism of Tripterygium glycosides combined with low molecular weight heparin calcium (LMWH) in the treatment of Henoch–Schönlein purpura nephritis (HSPN) in children. Methods. 64 cases of children patients with HSPN treated at Qilu Hospital (Qingdao) from January 2015 to May 2020 were selected and randomly divided into the control group and the observation group and 32 cases in each group. Conventional medical treatment was applied in the two groups, besides which the control group was given LMWH while the observation group was given Tripterygium glycosides based on the control group. The clinical efficacy and the indexes of clinical symptoms of the two groups were compared. Immune globulin level, fibrinogen content (FIB), prothrombin time (PT), platelet level (PLT), and activated partial thromboplastin time (APTT) level of the two groups were compared before and after the treatment. Results. The total effective rate in the observation group was significantly higher than that of the control group, and the recurrence rate in the observation group was lower than that in the control group. After treatment, urine red blood cell count and 24 h urine protein were obviously better than those of the control group. There was no statistically significant difference in PT between the two groups of children before and after treatment. The levels of PLT and FIB in the two groups of patients after treatment were significantly lower than before treatment, and the PLT levels in the observation group were lower than those in the control group. Conclusion. The combination of Tripterygium glycosides and LMWH had good clinical effects in the treatment of children with HSPN, and it could improve the clinical symptoms, the mechanism of which might be related to the increase of PT, a decrease of PLT, and the improvement of coagulation function.

Impacts of Low-Dose Total Glycosides of Tripterygium wilfordii plus Methotrexate on Immunological Function and Inflammation Level in Patients with Rheumatoid Arthritis

“…Tripterygium glycosides (TG) are a kind of natural active ingredient extracted from Tripterygium wilfordii, a southern Chinese vine that has long been used in traditional Chinese medicine [ 8 ]. Due to diverse pharmacological effects such as detoxification, blood-activating, inflammation prevention, and antiprocreation, the drug has been widely used to treat various types of inflammation [ 9 ]. It works by inhibiting dihydroorotate dehydrogenase, even in the treatment of active moderate-to-severe RA [ 10 ].…”

Subchronic toxicity evaluation of Huobahuagen extract and plasma metabolic profiling analysis combined with conventional pathology methods

“…of iron homeostasis (Dutt et al, 2022). And the coagulation function in male rats was likely to be impaired because of the anticoagulant activity of the constituents from Tripterygium plants (Jin et al, 2021).…”

“…The MCHC and APTT of rats in the HBHGE group decreased significantly ( p < 0.01 or 0.05), implying that the hemoglobin level in erythrocytes might be disturbed due to the impacts of compounds such as triptolide isolated from HBHGE via disturbance of iron homeostasis (Dutt et al, 2022). And the coagulation function in male rats was likely to be impaired because of the anticoagulant activity of the constituents from Tripterygium plants (Jin et al, 2021). Furthermore, after exposure to HBHGE for 12 weeks, biochemical indices in serum, such as AST and ALT, as the conventional biomarkers for clinical diagnosis and assessment of hepatocellular damage, slightly decreased compared with the vehicle group, which were contrary to those of previous reports (Yang et al, 2017).…”

Individualized medication based on pharmacogenomics and treatment progress in children with IgAV nephritis

“…Chinese medicine treatment has been considered an effective treatment for children with IgAV nephritis; its combination with immunosuppressants and CS produces additional positive effects, such as alleviating blood hypercoagulability in children, reducing proteinuria, and decreasing the recurrence rate of IgAV nephritis in children (Ding et al, 2019;Jin et al, 2021). Tripterygium wilfordii, a vine grown in southeastern China for thousands of years, is the most widely used Chinese medicine in children with IgAV nephritis.…”