The efficacy of topical royal jelly on healing of diabetic foot ulcers: a double‐blind placebo‐controlled clinical trial

Siavash, Mansour; Shokri, Samira; Haghighi, Sepehr; Shahtalebi, Mohammad Ali; Farajzadehgan, Ziba

doi:10.1111/iwj.12063

Cited by 70 publications

(55 citation statements)

References 33 publications

(36 reference statements)

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“…Various studies have reported antimicrobial activities of royal jelly against bacteria, fungi, and viruses, while in animal models, hypotensive, antitumour, antihypercholesterolemic, and anti-inflammatory activities have been observed (Ramadan and Al-Ghamdi, 2012). Moreover, antidiabetic properties, positive effects on benign prostatic hyperplasia, and wound healing of diabetic foot ulcers have been verified in clinical trials (Siavash et al, 2015; Khoshpey et al, 2016). Most studies concern crude royal jelly or protein and lipid subfractions, but in several cases the activity of singular compounds has been ascertained.…”

Section: Royal Jellymentioning

confidence: 96%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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Honeybees produce honey, royal jelly, propolis, bee venom, bee pollen, and beeswax, which potentially benefit to humans due to the bioactives in them. Clinical standardization of these products is hindered by chemical variability depending on honeybee and botanical sources, but different molecules have been isolated and pharmacologically characterized. Major honey bioactives include phenolics, methylglyoxal, royal jelly proteins (MRJPs), and oligosaccharides. In royal jelly there are antimicrobial jelleins and royalisin peptides, MRJPs, and hydroxy-decenoic acid derivatives, notably 10-hydroxy-2-decenoic acid (10-HDA), with antimicrobial, anti-inflammatory, immunomodulatory, neuromodulatory, metabolic syndrome preventing, and anti-aging activities. Propolis contains caffeic acid phenethyl ester and artepillin C, specific of Brazilian propolis, with antiviral, immunomodulatory, anti-inflammatory and anticancer effects. Bee venom consists of toxic peptides like pain-inducing melittin, SK channel blocking apamin, and allergenic phospholipase A2. Bee pollen is vitaminic, contains antioxidant and anti-inflammatory plant phenolics, as well as antiatherosclerotic, antidiabetic, and hypoglycemic flavonoids, unsaturated fatty acids, and sterols. Beeswax is widely used in cosmetics and makeup. Given the importance of drug discovery from natural sources, this review is aimed at providing an exhaustive screening of the bioactive compounds detected in honeybee products and of their curative or adverse biological effects.

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Section: Royal Jellymentioning

confidence: 96%

Therapeutic Properties of Bioactive Compounds from Different Honeybee Products

et al. 2017

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“…This is due to its vasodilation effects around the affected wound, which can help to dilate the blood vessels to enhance blood flow. It also helps to prevents infections due to its antimicrobial activities [115]. …”

Section: Health Benefits Of Royal Jellymentioning

confidence: 99%

Honey, Propolis, and Royal Jelly: A Comprehensive Review of Their Biological Actions and Health Benefits

Rao

Sammugam

Ramesh

et al. 2017

Oxidative Medicine and Cellular Longevity

619

471

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Background There are several health benefits that honeybee products such as honey, propolis, and royal jelly claim toward various types of diseases in addition to being food. Scope and Approach In this paper, the effects of honey, propolis, and royal jelly on different metabolic diseases, cancers, and other diseases have been reviewed. The modes of actions of these products have also been illustrated for purposes of better understanding. Key Findings and Conclusions An overview of honey, propolis, and royal jelly and their biological potentials was highlighted. The potential health benefits of honey, such as microbial inhibition, wound healing, and its effects on other diseases, are described. Propolis has been reported to have various health benefits related to gastrointestinal disorders, allergies, and gynecological, oral, and dermatological problems. Royal jelly is well known for its protective effects on reproductive health, neurodegenerative disorders, wound healing, and aging. Nevertheless, the exact mechanisms of action of honey, propolis, and royal jelly on the abovementioned diseases and activities have not been not fully elucidated, and further research is warranted to explain their exact contributions.

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“…However, observational studies and case reports would have been of value if they had reported safety data although there are reports about amputation. Honey's superiority as reported by these case reports and observational studies based on amputation rate can be justified if the [17,19] used topical royal jelly and its composition was water (50e60%), protients (18%), carbohydrates (15%), lipids (3e6%), mineral salts (1.5%), vitamins, 10-hydroxyl-2-decenoic acid, insulin like peptide. Manuka honey was used by Kamaratos A V et al in a randomized clinical trial [14].…”

Section: Discussionmentioning

confidence: 96%