The efficacy of topical preparations in reducing the incidence of Cutibacterium acnes at the start and conclusion of total shoulder arthroplasty: a randomized controlled trial

Symonds, Tristan; Grant, Alan; Doma, Kenji; Hinton, Darren; Wilkinson, Matthew; Morse, Levi

doi:10.1016/j.jse.2022.01.133

Cited by 8 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There were five level I studies (26,27,33,35,37) and five level II studies (25,28,32,34,36). A total of 9 studies were from the same journal.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Previous studies on the inclusion of BPO were limited, and the evidence level was low, which lacked convincing evidence (23, 24). As several new studies (25)(26)(27)(28) have been published, an updated systematic review and meta-analysis should be conducted. This study aimed to assess the safety and efficiency of BPO application in the shoulder to decrease C. acnes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The safety and efficiency of benzoyl peroxide for reducing Cutibacterium acnes in the shoulder: An updated systematic review and meta-analysis

Fan

Ma²,

Liu³

et al. 2023

Front. Surg.

View full text Add to dashboard Cite

BackgroundCutibacterium acnes (C. acnes), a common pathogen, contributes significantly to infections in shoulder surgery. Prevention of shoulder infection is crucial to improve postoperative functional recovery and reduce costs. This study aimed to perform a systematic review and meta-analysis to assess the safety and efficacy of 5% benzoyl peroxide (BPO) application in the shoulder to decrease C. acnes.MethodsThree electronic databases were searched as follows: PubMed, Embase, and the Cochrane Library databases. Data extraction for this study was performed by two independent reviewers, and only level I and level II studies were included. The outcome data sources of individual studies were pooled. The fixed-effect model was used to determine the meta-analysis.ResultsThere were five level I studies and five level II studies. The results showed that the 5% BPO group had a lower risk of C. acnes positivity [OR, 0.21 (0.15, 0.30), I2 = 24, p < 0.00001]. The pooled analysis results showed that there was no significant difference in the ability of 5% BPO and 5% BPO + clindamycin to reduce C. acnes. However, the lower rate of adverse events was significantly in favour of the non-BPO group compared with the 5% BPO group.ConclusionBPO can decrease C. acnes in the shoulder to prevent infection. However, the combination of BPO and clindamycin does not enhance this effect further.Level of evidenceII, Systematic review and meta-analysis.

show abstract

“…There were five level I studies (26,27,33,35,37) and five level II studies (25,28,32,34,36). A total of 9 studies were from the same journal.…”

Section: Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The safety and efficiency of benzoyl peroxide for reducing Cutibacterium acnes in the shoulder: An updated systematic review and meta-analysis

Fan

Ma²,

Liu³

et al. 2023

Front. Surg.

View full text Add to dashboard Cite

show abstract

“…None of the capsular samples from the experimental group was positive, whereas 21% were positive in the control group. Symonds et al 2 conducted a randomized controlled trial to compare the efficacy of 3 different preoperative skin preparations in reducing positive C. acnes culture rates in patients undergoing shoulder arthroplasty. A total of 101 patients were randomized into 3 groups: pHisoHex (hexachlorophene 3% detergent cleanser; sanofi-aventis), 5% benzoyl peroxide, and 5% benzoyl peroxide-clindamycin.…”

Section: Shoulder Arthroplasty Cutibacterium and Infection Preventionmentioning

confidence: 99%

What’s New in Shoulder and Elbow Surgery

Kim,

Hsu,

Ricchetti

2023

Journal of Bone and Joint Surgery

View full text Add to dashboard Cite

show abstract

Prospective registration of randomized clinical trials for total shoulder arthroplasty is low: a systematic review

Imam,

Sudah,

Bonney

et al. 2023

Journal of Shoulder and Elbow Surgery

View full text Add to dashboard Cite

The efficacy of topical preparations in reducing the incidence of Cutibacterium acnes at the start and conclusion of total shoulder arthroplasty: a randomized controlled trial

Cited by 8 publications

References 22 publications

The safety and efficiency of benzoyl peroxide for reducing Cutibacterium acnes in the shoulder: An updated systematic review and meta-analysis

The safety and efficiency of benzoyl peroxide for reducing Cutibacterium acnes in the shoulder: An updated systematic review and meta-analysis

What’s New in Shoulder and Elbow Surgery

Prospective registration of randomized clinical trials for total shoulder arthroplasty is low: a systematic review

Contact Info

Product

Resources

About