The Efficacy of Three Medicinal Plants : Garlic , Ginger and Mirazid and a Chemical Drug Metronidazole against Cryptosporidium Parvum. I-Immunological Response

Abouel-Nour, Mohamed Fathy; El-Shewehy, Dina M M; HAMADA, SHADIA; Morsy, Tosson A

doi:10.12816/0017916

Cited by 17 publications

(10 citation statements)

References 54 publications

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“…The beneficial effects of ginger were previously reported due to its active constituents such as zingerone, paradol, gingerols and shogaols (Adewusi et al, 1996). Also, Abouel-Nour et al (2015)…”

Section: Resultsmentioning

confidence: 91%

The Efficacy of Three Medicinal Plants ; Garlic , Ginger and Mirazid and a Chemical Drug Metronidazole against Cryptosporidium Parvum : Ii- Histological Changes

Abouel-Nour¹,

El-Shewehy²,

HAMADA³

2016

JESP

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Cryptosporidiosis parvum is a zoonotic protozoan parasite infects intestinal epithelial cells of man and animals causing a major health problem. This study was oriented to evaluate the protective and curative capacity of garlic, ginger and mirazid in comparison with metronidazole drug (commercially known) against Cryptosporidium in experimental mice. Male Swiss Albino mice experimentally infected with C. parvum were treated with medicinal plants extracts (Ginger, Mirazid, and Garlic) as compared to chemical drug Metronidazole. Importantly, C. parvum-infected mice treated with ginger, Mirazid, garlic and metronidazole showed a complete elimination in shedding oocysts by 9 th day PI. The reduction and elimination of shedding oocysts in response to the treatments might be attributable to a direct effect on parasite growth in intestines, sexual phases production and/ or the formation of oocysts. The results were evaluated histopathological examination of ileum section of control mice (uninfected, untreated) displayed normal architecture of the villi. Examination of infected mice ileum section (infected, untreated) displayed histopathological alterations from uninfected groups. Examination of ileum section prepared from mice treated with garlic, ginger, mirazid, and metronidazole displayed histopathological alterations from that of the control groups, and showed marked histologic correction in the pattern with the four regimes used in comparison to control mice. Garlic successfully eradicated oocysts of infected mice from stool and intestine. Supplementation of ginger to infected mice markedly corrected elevation in the inflammatory risk factors and implied its potential antioxidant, anti-inflammatory and immunomodulatory capabilities. Infected mice treated with ginger, mirazid, garlic and metronidazole showed significant symptomatic improvements during treatment.

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Section: Resultsmentioning

confidence: 91%

The Efficacy of Three Medicinal Plants ; Garlic , Ginger and Mirazid and a Chemical Drug Metronidazole against Cryptosporidium Parvum : Ii- Histological Changes

Abouel-Nour¹,

El-Shewehy²,

HAMADA³

2016

JESP

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“…In Saudi Arabia, Mecca Mur or Myrrh was successfully used in treatment of human fascioliasis (Al Mathal and Fouad, 2005) and animal fascioliasis (Abo-Zenadah, 2005) and against dicrocoeliasis dendriticum in man and animals (Al- Mathal and Fouad, 2004) as well as against Biomphalaria arabica (snail vector of S. mansoni in Saudi Arabia), adults and egg masses and fecundity (Al- Mathal and Fouad, 2006). Moreover, Mirazid safely treated zoonotic Bertiella studeri (Al-Mathal et al, 2010) On the other hand, Abouel-Nour et al (2015) in experimentally infected Albino mice studied the occurrence of immune and inflammatory responses in Cryptosporodium parvum invasion, when IFN-γ, TNF, IL-1b, IL-5 & IL-13 were released. The immune response elevation clarified infection posttreatment which elevated the pattern of cytokine release levels in comparison with the uninfected and infected controls.…”

Section: Discussionmentioning

confidence: 99%

Effect of Some Natural Products and Metronidazole on Immunityagainst Entamoeba Histolytica Infection in Mice

Abouel-Nour¹,

HAMADA

Kadhim³

2017

Journal of the Egyptian Society of Parasitology

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“…Moreover, plant extract might block or compete for receptor sites on intestinal surface, thus, leading to reduction in C. parvum colonization [47]. This might explain the apparent anti-Cryptosporidial activity of the high dose of ginger extract besides its previously recorded anti-Cryptosporidial [44,48] and antiprotozoal activities [18,19].…”

Section: Histopathological Examinationmentioning

confidence: 99%

Therapeutic Efficacy of Ginger (Zingiber officinale), Ginseng (Panax ginseng) and Sage (Salvia officinalis) Against Cryptosporidium parvum in Experimentally Infected Mice

et al. 2020

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C RYPTOSPORIDIUM parvum (C. parvum) is a worldwide zoonotic protozoan parasite infects most mammalian hosts causing a major health problem. The present study investigated the efficacy of ginger (Zingiber officinale), ginseng (Panax ginseng) and sage (Salvia officinalis) methanolic extracts on the progression of cryptosporidiosis in the experimental mice. Forty five mice experimentally infected with C. parvum were treated with medicinal plants extracts (ginger, ginseng and sage) as compared to the reference drug, Nitazoxanide (NTZ). Mice fecal smears were examined daily for 4 weeks post infection (PI). The results interpreted by oocysts count and histological examination of mice intestinal mucosa.The obtained results recorded that there was a statistically significant reduction in oocyst shedding in high dose ginger, ginseng and NTZ treated groups till no oocysts were found at days 21 and 23 PI, respectively. The infected non-treated, NTZ and low dose of both, ginseng and sage treated mice groups returned to excrete oocysts at low levels at day 27 PI while the other animal groups' feces were still negative for C. parvum oocysts. The histopathological examination showed that NTZ, high dose ginger and ginseng treated mice had more protective and curative effect on infected mice intestinal epithelium in comparison with other treatments used.In conclusion, these results proved the therapeutic efficacy of ginger, ginseng and sage medicinal plants against the C. parvum in experimentally infected mice, and that theginger extract had an obvious effect on infected mice than other treatments and such results could be adapted in similar infections in susceptible animals and man.

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The Efficacy of Three Medicinal Plants : Garlic , Ginger and Mirazid and a Chemical Drug Metronidazole against Cryptosporidium Parvum. I-Immunological Response

Cited by 17 publications

References 54 publications

The Efficacy of Three Medicinal Plants ; Garlic , Ginger and Mirazid and a Chemical Drug Metronidazole against Cryptosporidium Parvum : Ii- Histological Changes

The Efficacy of Three Medicinal Plants ; Garlic , Ginger and Mirazid and a Chemical Drug Metronidazole against Cryptosporidium Parvum : Ii- Histological Changes

Effect of Some Natural Products and Metronidazole on Immunityagainst Entamoeba Histolytica Infection in Mice

Therapeutic Efficacy of Ginger (Zingiber officinale), Ginseng (Panax ginseng) and Sage (Salvia officinalis) Against Cryptosporidium parvum in Experimentally Infected Mice

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