The Efficacy of Therapeutic Plasma Exchange in Antiphospholipid Antibody-positive Patients With Spontaneous Intracerebral Hemorrhage and High D-dimer Levels

Li, Chiao-Zhu; Liu, Feng‐Cheng; Li, Chiao-Ching; Lin, Maofang; Hsieh, Chih-Chuan; Lin, Benjamin C.; Chen, Nan‐Fu; Chen, Chunlin; Chung, Tzu-Tsao; Tang, Chi-Tun; Hueng, Dueng‐Yuan; Ju, Da‐Tong; Ma, Hsin‐I; Liu, Mingying; Lu, Ching Hsiang; Chen, Yuan-Hao

doi:10.1097/nrl.0000000000000159

Cited by 1 publication

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Even if the patient does not have DVT, the D-Dimer level remains useful in prognosis evaluation. [18][19][20][21][22][23][24][25][26][27] Therefore, compared to the complex and subjective PTP score, it is simpler and more practical to use Innovance D-Dimer combined with age adjustment cutoff value to judge the possibility of DVT in clinical work.…”

Section: Discussionmentioning

confidence: 99%

The Diagnostic Efficacy of Age-Adjusted D-Dimer Cutoff Value and Pretest Probability Scores for Deep Venous Thrombosis

Zhang

Liang

et al. 2019

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

This study seeks to evaluate the diagnostic value of D-Dimer Plus and Innovance D-Dimer as well as the age-adjusted cutoff value for D-dimer detection in combination with 4 pretest probability (PTP) scores for deep venous thrombosis (DVT). A total of 688 patients referred for lower extremity vascular compression venous ultrasonography for suspected DVT from January 2016 to May 2018 in the First Affiliated Hospital of Sun Yat-sen University underwent D-dimer tests combining with 4 PTP scores. The diagnostic efficacy of the Wells score was the highest of the 4 PTP scores. The diagnostic efficacy of Innovance D-Dimer for DVT was greater than that of D-Dimer Plus, with better sensitivity and negative predictive value, which were both greater than 98%. If the cutoff values were adjusted by age, the Innovation D-Dimer could further improve both the specificity and the positive predictive value, providing better diagnostic performance. When the 2 D-dimer detections were used in combination with 4 PTP scores for DVT diagnosis, separately, both the positive predictive value and the negative predictive value significantly improved for D-Dimer Plus, and the positive predictive values significantly improved for Innovance D-Dimer. However, the sensitivity, specificity, and negative predictive values did not obviously change. For our patients, Wells score had the best diagnostic efficacy for our patients with suspected DVT among the 4 PTP scores. Innovance D-Dimer in combination with age-adjusted cutoff values exhibited increased sensitivity and negative predictive value for DVT diagnosis and was equivalent to the diagnostic efficacy of the Innovance D-Dimer in combination with PTP scores.

show abstract

Section: Discussionmentioning

confidence: 99%

The Diagnostic Efficacy of Age-Adjusted D-Dimer Cutoff Value and Pretest Probability Scores for Deep Venous Thrombosis

Zhang

Liang

et al. 2019

Clin Appl Thromb Hemost

View full text Add to dashboard Cite

show abstract

The Efficacy of Therapeutic Plasma Exchange in Antiphospholipid Antibody-positive Patients With Spontaneous Intracerebral Hemorrhage and High D-dimer Levels

Abstract: The concurrent presence of positive aPL and a higher D-dimer level may worsen the neurological outcome of patients with a spontaneous ICH. Aggressive PE is effective for the treatment of such patients, decreasing the extent of the ICU hospitalization.

Cited by 1 publication

References 16 publications

The Diagnostic Efficacy of Age-Adjusted D-Dimer Cutoff Value and Pretest Probability Scores for Deep Venous Thrombosis

The Diagnostic Efficacy of Age-Adjusted D-Dimer Cutoff Value and Pretest Probability Scores for Deep Venous Thrombosis

Contact Info

Product

Resources

About