The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery against cestode infection of animals

Архипов, И А; Sadov, K. M.; Limova, Yulia V.; Sadova, A.; Varlamova, A. I.; Халиков, С. С.; Душкин, А. В.; Chistyachenko, Yulia S.

doi:10.1016/j.vetpar.2017.08.019

Cited by 16 publications

(8 citation statements)

References 10 publications

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“…Physicochemical properties and solid phase changes of obtained complexes were evaluated by methods of granulometric analysis, infrared spectral studies; thermal analysis; scanning electron microscopy; the analysis of solubility; and X-ray analysis. These methods were described previously in detail [8,22–24].…”

Section: Methodsmentioning

confidence: 99%

Influence of mechanochemical technology on anthelmintic efficacy of the supramolecular complex of fenbendazole with polyvinylpyrrolidone

Архипов¹,

Халиков²,

Sadov³

et al. 2019

J Adv Vet Anim Res

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Objective: The purpose of our research was to evaluate the effect of mechanochemical technology on the efficacy of supramolecular complex of fenbendazole (SMCF) with polyvinylpyrrolidone (PVP) polymer against some helminthosis of animals. Materials and methods: The SMCF samples with PVP were synthesized using a solid-state mechanochemical technology in activators of impact-abrading type and their physicochemical properties were analyzed. The efficacy of SMCF was studied on the laboratory model of Hymenolepis nana and Trichinella spiralis infection of mice and helminthosis of sheep. Results: In the trials conducted on laboratory models, the supramolecular complex showed 93.94% and 98.56 % efficacy at the dose of 1 mg/kg of body weight (b/w), while the substance of fenbendazole showed 7.97% and 8.33% efficacy at the same dose. A high efficacy (>94%) of the SMCF was revealed at the dose of 2.0 mg/kg of b/w at oral administration against nematodes in naturally infected sheep by the results of the fecal examination, while the substance of fenbendazole was active at the dose of 5.0 mg/kg at single oral administration. Moreover, the SMCF demonstrated 97.37% efficacy at the dose of 2 mg/kg against Moniezia spp. infection of sheep. Physicochemical studies confirmed the increase in solubility of the complex, reducing of particle sizes, amorphization of fenbendazole substance, and incorporating it with micelles of PVP. Conclusion: According to the results, supramolecular complex of fenbendazole with PVP was more active than the basic substance of fenbendazole and its anthelmintic properties were expanded.

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Section: Methodsmentioning

confidence: 99%

Influence of mechanochemical technology on anthelmintic efficacy of the supramolecular complex of fenbendazole with polyvinylpyrrolidone

Архипов¹,

Халиков²,

Sadov³

et al. 2019

J Adv Vet Anim Res

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“…Niclosamide (NS) is widely used for the treatment of cestode infection in animals, and to increase its solubility, it was done mechanochemical treated with PVP and obtained SD as a flowable beige powder [57]. Notable differences were observed with X-ray analysis in the SD of NS and PVP: it was established that a decrease of the intensity of the crystalline phase and disappearance of peaks (reflexes) of NS took place because of a disordering of the crystal structure and the formation of the SD in amorphous state ( Table 1).…”

Section: Solid Dispersions Of Anthelmintics For Animal Healthmentioning

confidence: 99%

Solid Dispersions of Anthelmintics and Plant Protection Preparations

Халиков

2021

Solids

Self Cite

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Because of the rapid development of nanotechnologies, materials, in particular, solid dispersions (SDs), which are actively introduced into the life of modern man, have been obtained. Special progress in this area is observed in industry and medicine. The use of SDs in agriculture is lagging far behind, despite the growing number of scientific papers on this topic. At the same time, the prospects for the introduction of SDs in the agro-industrial complex are obvious. The review presents the results of research on the development of innovative preparations based on SD to protect plants from diseases and pests of cultivated plants, as well as parasiticides to protect animal health based on modern achievements of nanotechnology. One of these technologies is the methods of mechanochemistry, which improve the properties of poorly soluble biologically active substances by their joint mechanical treatment with water-soluble polymers and auxiliary substances.

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“…Niclosamide (NS) is widely used to treat cestode infection of animals and for increasing its solubility was used its mechanochemical treatment with PVP and SD in the form of a flowing beige powder was taken [45] . Notable differences were observed with X-ray analysis in the SD of NS and PVP: it was established that a decrease of the intensity of the crystalline phase and disappearance of peaks (reflexes) of NS took place because of disordering of the crystal structure and the formation of the SD in amorphous state.…”

Section: Solid Dispersions Of Antiparasitic Drugs For Animal Healthmentioning

confidence: 99%

Solid Dispersions of Biologically Active Substances

Халиков¹

2020

Preprint

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Due to the rapid development of nanotechnologies, materials, in particular , solid dispersions (SDs), which are actively introduced into the life of modern man, have been obtained. Special progress in this area is observed in industry and medicine. The use of SDs in agriculture is lagging far behind, despite the growing number of scientific papers on this topic. At the same time, the prospects for the introduction of SDs in the agro-industrial complex are obvious. The review presents the results of research on the development of innovative preparations based on SD to protect plants from diseases and pests of cultivated plants, as well as parasiticides to protect animal health based on modern achievements of nanotechnology. One of these technologies is the methods of mechanochemistry, which improve the properties of poorly soluble biologically active substances by their joint mechanical treatment with water-soluble polymers and auxiliary substances.

show abstract

The efficacy of the supramolecular complexes of niclosamide obtained by mechanochemical technology and targeted delivery against cestode infection of animals

Cited by 16 publications

References 10 publications

Influence of mechanochemical technology on anthelmintic efficacy of the supramolecular complex of fenbendazole with polyvinylpyrrolidone

Influence of mechanochemical technology on anthelmintic efficacy of the supramolecular complex of fenbendazole with polyvinylpyrrolidone

Solid Dispersions of Anthelmintics and Plant Protection Preparations

Solid Dispersions of Biologically Active Substances

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