The Efficacy of the Kampo Formula Keishikashakuyakuto for Irritable Bowel Syndrome: A Phase 3, Multicenter, Double-Blind, Placebo- Controlled, Randomized Controlled Trial

Higurashi, Takuma; Fuyuki, Akiko; Ohkubo, Hidenori; Iida, Hiroshi; Inamori, Masahiko; Taguri, Masataka; Komiya, Yasuhiko; Goto, Shungo; Taniguchi, Leo; Okada, Nagaya; Ito, Takafumi; Mizuki, Akira; Manabe, Noriaki; Haruma, Ken; Nagasaka, Mitsuo; Nakagawa, Yoshihito; Ohmiya, Naoki; Yamamoto, Sayuri; Funaki, Yasushi; Kasugai, Kunio; Nakajima, Atsushi

doi:10.4172/2167-0870.1000345

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…Kyuki-kyogai-to (90.0%, 77.4) was used as the first prescription for menorrhagia (22). Shakuyaku-kanzo-to (97.8%, 96.2) was used as the first prescription for leg cramps (23). Sho-seiryu-to (86.0%, 78.1) was used as the first prescription for dripping nose (24).…”

Section: Resultsmentioning

confidence: 99%

“…The following strengths and weaknesses of traditional Japanese herbal medicine were identified as a result of comprehensively examining the efficacy and effective rate of each Kampo formula. The efficacy with which Kikyo-to treated a sore throat (28) was 92.8% and its effective rate was 98.6%, and the efficacy with which Shakuyakukanzo-to treated leg muscle cramps (23) was 97.8% and its effective rate was 96.2%. This indicates that a sore throat and muscle cramps are easily cured to Kampo treatment.…”

Section: Discussionmentioning

confidence: 99%

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2023

ACIM

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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2023

ACIM

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“…In Oriental medicine, keishikashakuyakuto is an effective treatment of functional gastrointestinal disorders, commonly used for all subtypes of IBS ( Saitoh et al, 1999 ; Oka et al, 2014 ; Higurashi et al, 2018 ; Kimura, 2019 ). According to our results, keishikashakuyakuto controlled the increased intestinal peristalsis in ES mice but did not affect naive mice, suggesting that keishikashakuyakuto not only suppressed intestinal motility but also improved stress-induced diarrhea-like symptom.…”

Section: Discussionmentioning

confidence: 99%

Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice

et al. 2022

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Increasing evidence has demonstrated that emotional states and intestinal conditions are inter-connected in so-called “brain–gut interactions.” Indeed, many psychiatric disorders are accompanied by gastrointestinal symptoms, such as the irritable bowel syndrome (IBS). However, the functional connection remains elusive, partly because there are few useful experimental animal models. Here, we focused on a highly validated animal model of stress-induced psychiatric disorders, such as depression, known as the chronic vicarious social defeat stress (cVSDS) model mice, which we prepared using exposure to repeated psychological stress, thereafter examining their intestinal conditions. In the charcoal meal test and the capsaicin-induced hyperalgesia test, cVSDS model mice showed a significantly higher intestinal transit ratio and increased visceral pain-related behaviors, respectively. These changes persisted over one month after the stress session. On the other hand, the pathological evaluations of the histological and inflammatory scores of naive and cVSDS model mice did not differ. Furthermore, keishikashakuyakuto—a kampo medicine clinically used for the treatment of IBS—normalized the intestinal motility change in cVSDS model mice. Our results indicate that cVSDS model mice present IBS-like symptoms such as chronic intestinal peristaltic changes and abdominal hyperalgesia without organic lesion. We therefore propose the cVSDS paradigm as a novel animal model of IBS with wide validity, elucidating the correlation between depressive states and intestinal abnormalities.

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Erkrankungen des Gastrointestinaltrakts

Bijak

2018

Dtsch Z Akupunkt

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Das aktuelle Schwerpunktthema "Erkrankungen des Gastrointestinaltrakts (GI)" entzieht sich einer umfassenden Darstellung zur Gänze. Wie gliedern, wo anfangen? Bei A wie Appetit (mit all den unterschiedlichen Essstörungen), um dann mit Pathologien wie Zöliakie zu enden? Oder anatomisch von oben nach unten, also von den Zähnen und der Zunge bis zum Analbereich? Der "Darm hat zwar Charme" [1], aber "Darm krank-alles krank" [2]. Also kann jeder Versuch einer holistischen Betrachtung des Themas ohnehin nur scheitern. Um der Einführung doch noch Struktur zu verleihen, beschränkt sie sich auf einige Übersichtsarbeiten passend zu den Therapieformen. Und was liegt näher, als mit Akupunktur zu beginnen? Einführung zum Thema

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The Efficacy of the Kampo Formula Keishikashakuyakuto for Irritable Bowel Syndrome: A Phase 3, Multicenter, Double-Blind, Placebo- Controlled, Randomized Controlled Trial

Cited by 3 publications

References 21 publications

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Repeated psychological stress, chronic vicarious social defeat stress, evokes irritable bowel syndrome-like symptoms in mice

Erkrankungen des Gastrointestinaltrakts

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