The efficacy of some newer broad spectrum anthelmintics against third-stage larvae of Ancylostoma caninum in the mouse

Abstract

The efficacy of eight anthelmintics against Ancylostoma caninum larvae in the skeletal muscles of mice was evaluated. Levamisole (5 × 40 mg kg), thiabendazole (5 × 400mg kg), oxfendazole (5 × 100mg kg), albendazole (5× 1OOmg kg), flubendazole (5 × 200 mg kg), benacil (5 × 200 mg kg) and phenacizole (5 × 200mg kg) showed marked larvicidal activity (98 to 99%). Sch 18099 did not show larvicidal activity even at 5×400 mg kg.

Efficacy of various anthelmintics against third-stage larvae of Ancylostoma caninum in the brain of mice

“…Albendazole, flubendazole, benacil, phenacizole, oxfendazole and thiabendazole were found to be effective drugs. We have also shown that these drugs are effective against larvae migrated in the muscles of mice as well (BHOPALE & BHATNAGAR, 1985).…”

“…Oxfendazole at the dose level of 5x400 mg/kg showed 88-33% reduction of larvae as compared to untreated control. This drug has also been proved to be effective against larvae of Ancylostoma caninum (BHOPALE & BHATNAGAR, 1985) in mice, larvae of Toxocara canis in brain and muscles of mice (NICHOLAS & STEWART, 1979). Oxfendazole also showed good efficacy in experimental trichinosis of mice (BOLAS FERNANDEZ, 1979;SPALDONOVA & CORBA, 1980).…”

“…Several broad spectrum anthelmintics are available for the treatment of adult intestinal nematodes, but very few are effective against migrating larvae. Although efficacy of some anthelmintics against third stage larvae of A. caninum in the skeletal muscles of mice (KESSLER & STOYE, 1971;BHOPALE & BHATNAGAR, 1985) and Mastomys natalensis (LAMMLER et al, 1970;LAMMLER & EL-GENDI, 1978) have been reported, there is no report on the efficacy of these drugs against larvae which have migrated to the brain. The present communication provides additional information on the efficacy of some old as well as new drugs against A. caninum larvae in the mouse brain.…”

One-week therapy with oral albendazole in hookworm-related cutaneous larva migrans: A retrospective study on 78 patients

“…Albendazole, at the dosage of 500 mg/kg, showed marked larvicidal activity (98-99%) against third stage larvae of Ancylostoma caninum in skeletal muscles of mice (8).…”

Fixed Cutaneous Sporotrichosis

“…5 Primary Cutaneous Lymphoblastic Lymphoma of Non-B, Non-T Phenotype To the Editor.\p=m-\Lymphoblastic lymphoma (LBL) is a tumor of lymphoid precursors with a lymphomatous presentation. Furthermore, itraconazole seems to be well tolerated with minimal side effects and with much lower toxic effects than ketoconazole.…”