The efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn

Duman, Levent; Büyükyavuz, Behçet İlker; Altuntaş, İrfan; Gökçimen, Alpaslan; Ceyhan, Levent; Darıcı, Hakan; Aylak, Firdevs; Tomruk, Önder

doi:10.1016/j.jpedsurg.2011.03.001

Cited by 12 publications

(4 citation statements)

References 19 publications

(22 reference statements)

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“…27 Furthermore, 5-FU has shown some success in the treatment and prevention of fibrosis in different pathologies, such as tendon adhesions after tendon repairs, scar formation after skin incisions, capsule formation around breast implants and stricture formation after corrosive esophageal damages. [28][29][30][31] Based on all this, we assumed that 5-FU can also prevent fibrotic process in the liver by inhibiting the functions of MFs or by suppressing portal fibroblasts, which are an important source of MFs in cholestatic liver injury. To prove this, we used biochemical and histopathologic 0.010 G1-G2 <0.001 G1-G2 0.004 G1-G2 0.003 G1-G2 0.003 G1-G2 <0.001 G1-G3 0.004 G1-G3 <0.001 G1-G3 <0.001 G1-G3 <0.001 G1-G3 0.643 G2-G3 0.988 G2-G3 0.728 G2-G3 0.856 G2-G3 0.764 G2-G3 parameters to determine the degree of fibrosis.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of 5-Fluorouracil Therapy on Liver Fibrosis in Rats: Experimental Study

OKAY¹,

Duman²,

Çiriş³

et al. 2022

Turkiye Klinikleri J Med Sci

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Liver fibrosis is a complex process caused by an imbalance between collagen synthesis to extracellular matrix (ECM) and its degradation. 1 It is a common pathological condition which gradually disrupts the normal architecture of the liver. If the fibrotic process continues without treatment, advanced stage of fibrosis results in cirrhosis, and eventually leads to liver failure and even death. 2 Unfortunately, this longterm disease remains a major concern for clinicians due to the lack of effective therapy till now. 3,4

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Section: Discussionmentioning

confidence: 99%

The Efficacy of 5-Fluorouracil Therapy on Liver Fibrosis in Rats: Experimental Study

OKAY¹,

Duman²,

Çiriş³

et al. 2022

Turkiye Klinikleri J Med Sci

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“…The ideal application is to give slow and small doses in the form of instillation (Demirbilek et al 1994). In different studies, NaOH solution (10–40%; Herek et al, 2010) was applied in the lumen between 60 s (Senturk et al, 2010) and 3 min intervals (Duman et al, 2011). In our study, NaOH solution was applied at a strength of 37.5% over a period of 60 s, and then the solution was aspirated.…”

Section: Discussionmentioning

confidence: 99%

A novel model approach for esophageal burns in rats

et al. 2013

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“…Histopathological evaluation was performed for all animals to determine inflammation status and fibroblast proliferation. Moreover, submucosal collagen increase was scored between 0 and 5 in three categories: muscularis mucosa damage, tunica muscularis damage, and collagen accumulation (Table ) …”

Section: Methodsmentioning

confidence: 99%

Effects of tenoxicam in experimental corrosive esophagitis model

et al. 2014

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Esophageal stricture, one of the important complications of corrosive esophagus, develops following edema and granulation tissue that forms during and after the inflammatory reactions. Tenoxicam, a non-steroid anti-inflammatory drug with a long half-life, prevents various leukocyte functions including phagocyte and histamine secretion by inhibiting prostaglandin synthesis and removes various oxygen radicals in the region of inflammation. We designed this as a histopathological study using tenoxicam in rats for which we created a corrosive esophagus model. After necessary authorizations were obtained, the study was performed in Çanakkale 18 Mart University experimental animal laboratory. Twenty-four Wistar albino rats, weighing 220-240 g, were used for the experiment. Experimental animals were randomized into three groups: tenoxicam group (group T, n:8), control group (group C, n:8), and sham group (group S, n:8). Tenoxicam 0.5 mg/kg/day was administered to animals in group T, where esophageal burn was developed experimentally, 5 mg/kg 0.9% NaCL was administered i.p. to rats in group C for 15 days, once in 24 hours. No procedure was applied to rats in group S. After 15 days, all animals were sacrificed under general anesthesia and their esophagi were extracted. As a result of histopathological evaluation, inflammation and fibroblast proliferation was not observed in rats in the sham group (group S). Intense inflammation was observed in six rats (6+/2-) in the control group, and fibroblast proliferation was observed as 5+/3-. And in treatment groups, inflammation was evaluated as 3+/5-, and fibroblast proliferation as 3+/5-. In our study, histopathologic damage score was higher in the control group (P < 0.005). We deduce that tenoxicam can be useful in the treatment of caustic esophageal injuries in the acute phase, but think that these drugs require further researches and clinical studies before routine clinical use.

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The efficacy of single-dose 5-fluorouracil therapy in experimental caustic esophageal burn

Cited by 12 publications

References 19 publications

The Efficacy of 5-Fluorouracil Therapy on Liver Fibrosis in Rats: Experimental Study

The Efficacy of 5-Fluorouracil Therapy on Liver Fibrosis in Rats: Experimental Study

A novel model approach for esophageal burns in rats

Effects of tenoxicam in experimental corrosive esophagitis model

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