The Efficacy of Psychological Care and Chinese Herbal Decoction in Postoperative Chemotherapy Patients with Endometrial Cancer

Liu, Jinjie; Wang, Juan; Guo, Yang; Zhang, Hongmei

doi:10.1155/2022/5700637

Cited by 3 publications

(3 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study of Azizi et al [37] showed that the pain index, fever time, length of hospital stay, recurrence rate within 3 years, quality of life (QLQ-C30) score, pregnancy status after 1 year, term productivity and treatment satisfaction scores were better than those of the surgery group after hysteroscopic resection of early endometrial cancer. Liu et al [38] showed that the application of supplemented Chinese herbal decoction could improve pain symptoms, and quality of life, enhance cellular immunity and reduce adverse reaction rates in patients with endometrial cancer undergoing chemotherapy. The above results indicate that the combination of S. miltiorrhiza with postoperative chemoradiotherapy or combined with Western medicine can be used to enhance clinical efficacy and improve patients' related symptoms.…”

Section: Reducing the Side Effects Of Chemotherapy Drugs And Enhancin...mentioning

confidence: 99%

Research progress on the mechanism of action of Salvia miltiorrhiza and its components in the treatment of endometrial carcinoma

Chunhua Zhang,

Qing Liu,

Ziyi Qi

et al. 2024

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

The incidence and mortality of endometrial carcinoma (EC) are increasing year by year. Although the curative effect of surgery and commonly used drugs is clear, it is accompanied by obvious side effects, and safe and effective means are urgently needed to promote the curative effect and decrease the toxicity of drugs. Traditional Chinese medicine has been passed down for thousands of years in China and has proved to be advantageous in the treatment of various cancers and the auxiliary enhancement and reduction of toxicity. This paper reviewed the role and internal mechanism of Salvia miltiorrhiza in preventing and treating endometrial carcinoma by referring to relevant literature and works, so as to more comprehensively understand and grasp the research status, effective components, curative effect and effective mechanism of S. miltiorrhiza in preventing and treating endometrial carcinoma, and provide ideas and basis for clinical use and basic research.

show abstract

Section: Reducing the Side Effects Of Chemotherapy Drugs And Enhancin...mentioning

confidence: 99%

Research progress on the mechanism of action of Salvia miltiorrhiza and its components in the treatment of endometrial carcinoma

Chunhua Zhang,

Qing Liu,

Ziyi Qi

et al. 2024

Cell Mol Biol (Noisy-le-grand)

View full text Add to dashboard Cite

show abstract

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

mentioning

confidence: 99%

“…Tis article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”

mentioning

confidence: 99%

Retracted: The Efficacy of Psychological Care and Chinese Herbal Decoction in Postoperative Chemotherapy Patients with Endometrial Cancer

Engineering¹

2023

Journal of Healthcare Engineering

View full text Add to dashboard Cite

A Strategy based on Bioinformatics and Machine Learning Algorithms Reveals Potential Mechanisms of Shelian Capsule against Hepatocellular Carcinoma

Zhou,

Tan,

Zhang

et al. 2024

CPD

View full text Add to dashboard Cite

Background: Hepatocellular carcinoma (HCC) is a prevalent and life-threatening form of cancer, with Shelian Capsule (SLC), a traditional Chinese medicine (TCM) formulation, being recommended for clinical treatment. However, the mechanisms underlying its efficacy remain elusive. This study sought to uncover the potential mechanisms of SLC in HCC treatment using bioinformatics methods. Methods: Bioactive components of SLC were obtained from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and HCC-related microarray chip data were sourced from the Gene Expression Omnibus (GEO) database. The selection criteria for components included OB ≧ 30% and DL ≧ 0.18. By integrating the results of differential expression analysis and weighted gene co-expression network analysis (WGCNA), disease-related genes were identified. Therapeutic targets were determined as shared items between candidate targets and disease genes. Protein-protein interaction (PPI) network analysis was conducted for concatenated genes, with core protein clusters identified using the MCODE plugin. Machine learning algorithms were applied to identify signature genes within therapeutic targets. Subsequently, immune cell infiltration analysis, single-cell RNA sequencing (sc-RNA seq) analysis, molecular docking, and ADME analysis were performed for the screened genes. Result: A total of 153 SLC ingredients and 170 candidate targets were identified, along with 494 HCC-related disease genes. Overlapping items between disease genes and drug candidates represented therapeutic genes, and PPI network analysis was conducted using concatenated genes. MCODE1 and MCODE2 cluster genes underwent Disease Ontology (DO), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Four signature genes (TOP2A, CYP1A2, CYP2B6, and IGFBP3) were identified from 28 therapeutic genes using 3 machine learning algorithms, with ROC curves plotted. Molecular docking validated the interaction modes and binding abilities between signature genes and corresponding compounds, with free binding energy all <-7 kcal/mol. Finally, ADME analysis revealed similarities between certain SLC components and the clinical drugs Sorafenib and Lenvatinib. Conclusion: In summary, our study revealed that the mechanism underlying the anti-HCC effects of SLC involves interactions at three levels: components (quercetin, beta-sitosterol, kaempferol, baicalein, stigmasterol, and luteolin), pathways (PI3K-Akt signaling pathway, TNF signaling pathway, and IL-17 signaling pathway), and targets (TOP2A, CYP1A2, CYP2B6, and IGFBP3). This study provides preliminary insights into the potential pharmacological mechanisms of SLC in HCC treatment, aiming to support its clinical application and serve as a reference for future laboratory investigations.

show abstract

The Efficacy of Psychological Care and Chinese Herbal Decoction in Postoperative Chemotherapy Patients with Endometrial Cancer

Cited by 3 publications

References 35 publications

Research progress on the mechanism of action of Salvia miltiorrhiza and its components in the treatment of endometrial carcinoma

Research progress on the mechanism of action of Salvia miltiorrhiza and its components in the treatment of endometrial carcinoma

Retracted: The Efficacy of Psychological Care and Chinese Herbal Decoction in Postoperative Chemotherapy Patients with Endometrial Cancer

A Strategy based on Bioinformatics and Machine Learning Algorithms Reveals Potential Mechanisms of Shelian Capsule against Hepatocellular Carcinoma

Contact Info

Product

Resources

About