The Efficacy of Probiotics in the Management of Helicobacter Pylori: A Systematic Review

Abstract

Helicobacter pylori is a Gram-negative microorganism that causes chronic dyspepsia, gastritis, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric adenocarcinoma. Various antibiotic regimens are employed to eradicate it; however, antibiotic resistance has skyrocketed in recent years, resulting in a reduction in eradication rates. As a result, numerous novel therapeutic approaches are being adopted in clinical practice, and probiotics are being extensively investigated. Probiotics are living bacteria that, when consumed, offer many medicinal advantages that may be accomplished by altering the amount or activity of gut flora. Their beneficial influence on gut health, immune system modulation, and cancer therapy is the subject of extensive investigation. This is owing to their perceived safety and simplicity of use. The primary objective of this review is to learn about and investigate the function of probiotics in the eradication of H. pylori , either alone or in conjunction with traditional treatments. Data have been collected from PubMed, PubMed Central, Medline, Cochrane, and Google Scholar, and relevant articles have been chosen following the PRISMA guidelines. Our search resulted in 2489 records, of which 123 full-text articles were screened for eligibility. Two reviewers independently performed the quality appraisal of 16 relevant articles, and ultimately 11 high-quality studies are included in this review. In conclusion, probiotic monotherapy does not have a significant effect on the eradication rates of H. pylori , but in conjunction with standard treatment regimens, there was mild improvement in the eradication rates but a significant reduction of side effects due to antibiotics.

The Efficacy and Safety of Vonoprazan and Amoxicillin Dual Therapy for Helicobacter pylori Infection: A Systematic Review and Network Meta-Analysis

“…Patient education had positive effects on the H. pylori eradication rate and medication adherence [45]. Probiotics, in conjunction with recommended therapies, slightly increased the eradication rate and significantly decreased the adverse effects of antibiotics [46]. Susceptibility testing may guide the selection of the most effective treatment regimens and improve the eradication rate to exceed 90% [47].…”

The effectiveness of treatment with probiotics inHelicobacter pylorieradication: results from an umbrella meta-analysis on meta-analyses of randomized controlled trials

“…Various studies have confirmed that probiotics in conjunction with standard therapies have a beneficial effect on these complications and help to improve patient compliance to the routine treatments. 16,39 Another important point is the lack of a significant ameliorating effect of probiotics alone on H. pylori eradication. 39 In conclusion, combination of probiotics with traditional therapies can be considered as a novel therapeutic approach for H. pylori infection.…”

“…16,39 Another important point is the lack of a significant ameliorating effect of probiotics alone on H. pylori eradication. 39 In conclusion, combination of probiotics with traditional therapies can be considered as a novel therapeutic approach for H. pylori infection.…”

A review on the research progress on non-pharmacological therapy of Helicobacter pylori

“…Several systematic reviews and meta-analyses show that probiotic monotherapy has a minimal impact on the eradication rates of H. pylori. However, when used in supplementary therapy, probiotics are effective in increasing eradication rates with reduced side effects (Losurdo et al, 2018;Zhou et al, 2019;Zhang et al, 2020;Penumetcha et al, 2021). The Maastricht VI/Florence consensus report also states that probiotics can increase the eradication rate of H. pylori by reducing side effects associated with eradication therapy rather than through direct effects on H. pylori, but the benefit only apply to certain strains of probiotics (Malfertheiner et al, 2022).…”