The efficacy of probiotic supplementation in rheumatoid arthritis: a meta-analysis of randomized, controlled trials

Rudbane, Seyed Mohammad Aqaeinezhad; Rahmdel, Samane; Abdollahzadeh, Seyedeh Maryam; Zare, Morteza; Bazrafshan, Azam; Mazloomi, Seyed Mohammad

doi:10.1007/s10787-017-0436-y

Cited by 54 publications

(32 citation statements)

References 18 publications

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“…Lately, a number of systematic reviews, a meta-analysis, and expert opinions have expressed criticism on the probiotics and prebiotics claimed effects and safety [130][131][132][133][134][135][136].…”

Section: Probiotics and Prebioticsmentioning

confidence: 99%

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

et al. 2020

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Mismanagement of bacterial infection therapies has undermined the reliability and efficacy of antibiotic treatments, producing a profound crisis of the antibiotic drug market. It is by now clear that tackling deadly infections demands novel strategies not only based on the mere toxicity of anti-infective compounds. Host-directed therapies have been the first example as novel treatments with alternate success. Nevertheless, recent advances in the human microbiome research have provided evidence that compounds produced by the microbial metabolism, namely postbiotics, can have significant impact on human health. Such compounds target the host-microbe-pathogen interface rescuing biotic and immune unbalances as well as inflammation, thus providing novel therapeutic opportunities. This work discusses critically, through literature review and personal contributions, these novel nonantibiotic treatment strategies for infectious disease management and resistance prevention, which could represent a paradigm change rocking the foundation of current antibiotic therapy tenets.

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Section: Probiotics and Prebioticsmentioning

confidence: 99%

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

et al. 2020

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“…By contrast, Lactobacillus bifidus showed a probable ability to promote joint swelling in germ free mice, by TLR2/TLR4 activation (3, 34, 46). Although these studies have globally suggested the potential benefits of probiotic supplementation in RA, until now the evidence is not considered strong enough to propose the inclusion of probiotic supplements in the diet of RA patients as part of their disease management strategy (47).…”

Section: Diet and Rheumatoid Arthritismentioning

confidence: 99%

Diet, Microbiota, and Gut Permeability—The Unknown Triad in Rheumatoid Arthritis

et al. 2018

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Growing experimental and clinical evidence suggests that a chronic inflammatory response induced by gut dysbiosis can critically contribute to the development of rheumatic diseases, including rheumatoid arthritis (RA). Of interest, an adherence to a Mediterranean diet has been linked to a reduction in mortality and morbidity in patients with inflammatory diseases. Diet and intestinal microbiota are modifying factors that may influence intestinal barrier strength, functional integrity, and permeability regulation. Intestinal microbiota may play a crucial role in RA pathogenesis, but up to now no solid data has clarified a mechanistic relationship between gut microbiota and the development of RA. Nonetheless, microbiota composition in subjects with RA differs from that of controls and this altered microbiome can be partially restored after prescribing disease modifying antirheumatic drugs. High levels of Prevotella copri and similar species are correlated with low levels of microbiota previously associated with immune regulating properties. In addition, some nutrients can alter intestinal permeability and thereby influence the immune response without a known impact on the microbiota. However, critical questions remain to be elucidated, such as the way microbiome fluctuates in relation to diet, and how disease activity may be influenced by changes in diet, microbiota or diet-intestinal microbiota equilibrium.

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“… 14 , 15 Recent meta-analytic human studies reported favorable microbiome effects on clinical manifestations in diabetes, necrotizing enterocolitis, inflammatory bowel disease, and eczema but not in rheumatoid arthritis. 16 – 20 There has also been a clinical trial reporting that administration of Bifidobacterium mixture may attenuate dry eye syndrome. 21 IRT5 is a probiotic mixture of five strains that includes Bifidobacterium bifidum , Lactobacillus acidophilus , Lactobacillus casei , Lactobacillus reuteri , and Streptococcus thermophilus.…”

mentioning

confidence: 99%

IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model

Choi

Ryu

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Purpose While the association between the gut microbiome and the immune system has been studied in autoimmune disorders, little is known about ocular disease. Previously we reported that IRT5, a mixture of five probiotic strains, could suppress autoimmune dry eye. In this study, we investigated the mechanism by which IRT5 performs its immunomodulatory function in a mouse model of autoimmune dry eye. Methods NOD.B10.H2b mice were used as an autoimmune dry eye model. Either IRT5 or PBS was gavaged orally for 3 weeks, with or without 5 days of antibiotic pretreatment. The effects on clinical features, extraorbital lacrimal gland and spleen proteins, and fecal microbiota were analyzed. Results The ocular staining score was lower, and tear secretion was higher, in the IRT5-treated groups than in the PBS-treated groups. After IRT5 treatment, the downregulated lacrimal gland proteins were enriched in the biological processes of defense response and immune system process. The relative abundances of 33 operational taxonomic units were higher, and 53 were lower, in the feces of the IRT5-treated groups than in those of the PBS-treated groups. IRT5 administration without antibiotic pretreatment also showed immunomodulatory functions with increases in the Lactobacillus helveticus group and Lactobacillus hamsteri . Additional proteomic assays revealed a decrease of proteins related to antigen-presenting processes in the CD11b + and CD11c + cells of spleen in the IRT5-treated groups. Conclusions Changes in the gut microbiome after IRT5 treatment improved clinical manifestations in the autoimmune dry eye model via the downregulation of antigen-presenting processes in immune networks.

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The efficacy of probiotic supplementation in rheumatoid arthritis: a meta-analysis of randomized, controlled trials

Cited by 54 publications

References 18 publications

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

Postbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?

Diet, Microbiota, and Gut Permeability—The Unknown Triad in Rheumatoid Arthritis

IRT5 Probiotics Changes Immune Modulatory Protein Expression in the Extraorbital Lacrimal Glands of an Autoimmune Dry Eye Mouse Model

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