The efficacy of pregabalin for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled double-blind study

Srivastava, VK; Agrawal, Sanjay; Kadiyala, Venkat N.; Ahmed, Mukadder; Sharma, Sunil; Kumar, Rajiv

doi:10.1007/s00540-014-1911-x

Cited by 43 publications

(41 citation statements)

References 16 publications

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“…Besides the two types of urological operations, nonurological surgery was also included in present study. 14,15 The incidences of CRBD in the control group at 1, 2, 6, 12, and 24 hours after TURBT were 66.7% (22 of 33 cases), 90.9% (30 of 33 cases), 91.2% (83 of 91 cases), 84.6% (77 of 91 cases), and 81.3% (74 of 91cases), respectively. The incidences of CRBD in the control group at 1, 2, 6, and 12 hours after PCNL were 69.3% (131 of 189 cases), 62.4% (118 of 189 cases), 50.3% (95 of 189 cases), and 31.25% (10 of 32 cases), respectively.…”

Section: Search Resultsmentioning

confidence: 98%

Management of Catheter-Related Bladder Discomfort in Patients Who Underwent Elective Surgery

Bai

Wang

Liu

et al. 2015

Journal of Endourology

141

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Section: Search Resultsmentioning

confidence: 98%

Management of Catheter-Related Bladder Discomfort in Patients Who Underwent Elective Surgery

Bai

Wang

Liu

et al. 2015

Journal of Endourology

141

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“…The sample size was calculated by employing a two-sided P level. The reported incidence of CRBD in our previous study, secondary to intraoperative catheterization, was 70% in spinal surgery at 0 h (primary endpoint) [7]. Assuming that the CRBD incidence in Group C was equal to that of the previous study and the CRBD incidence in Group T was set as 30% (with α = 0.05 and β = 0.80) based on a pilot study, the effect size used was 0.8 based on these proportions (Cohen' s h = 2 *arcsin p 1 -2 *arcsin p 2 = 0.82), [14] which resulted in a sample of 25 patients per group to attain the desired effect.…”

Section: Sample Size Calculationmentioning

confidence: 94%

“…Darifenacin and solifenacin have recently been studied for the prevention of CRDB with varying success rates [5]. Other groups of drugs, such as antiepileptics (gabapentin and pregabalin) [6,7], ketamine [8], tramadol [9], and dexmedetomidine [10], have shown varying degrees of success for prevention of CRBD.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study

Srivastava

Agrawal

Deshmukh

et al. 2020

Korean J Anesthesiol

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Background: Catheter-related bladder discomfort (CRBD) is a frequent complaint after awakening from anesthesia in patients receiving perioperative bladder catheterization. Overactive bladder (OAB) and CRBD show similar symptoms; thus, drugs used for the management of OAB influence symptoms of CRBD. Trospium chloride has been found effective in managing resistant cases of OAB. We evaluated the efficacy of oral trospium on CRBD in the postoperative period. Methods: Sixty-four male and female adult patients, with planned spinal surgery and requiring urinary bladder catheterization, were randomly divided into two groups of 32 each. Group T patients received 60 mg extended-release oral trospium (extended-release) 1 h before induction of anesthesia and Group C patients received a similar-looking placebo. The anesthetic technique was identical in both groups. The CRBD score was evaluated in the postoperative ward using a 4-point scale (1 = no discomfort, 2 = mild, 3 = moderate, 4 = severe). Readings were recorded on arrival (0 h), and 1 h, 2 h, and 6 h postoperatively. All patients received fentanyl for postoperative pain relief. Results: The incidence of CRBD was significantly higher in Group C than in Group T at 0 h (66% vs. 22%, P = 0.001) and 1 h postoperatively (72% vs. 28%, P = 0.001). The incidence of moderate to severe CRBD was higher in Group C at postoperative 2 h (82% vs. 14%, P = 0.004). There was no significant difference in postoperative fentanyl requirements. Conclusions: Pretreatment with 60 mg extended release trospium reduced the incidence and severity of CRBD in the early postoperative period.

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“…The mechanism 3 of CRBD is caused by involuntary contraction of the bladder, as mediated by muscarinic receptors, especially the subtype M3 receptor [4]. Various agents have been employed to manage CRBD, with varying degrees of success, including tolterodine , oxybutynin, butylscopolamine, paracetamol, gabapentin, pregablin, ketamine, tramadol, dexmedetomidine, darifenacin and solifenacin [5][6][7][8][9][10][11][12][13][14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of intravenous lidocaine and dexmedetomidine infusion for prevention of postoperative catheter-related bladder discomfort: a randomized controlled trial

et al. 2019

Preprint

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Background Catheter-related bladder discomfort (CRBD) frequently occurs during recovery in patients who undergo intra-operative urinary catheterization distress. We conducted this study to compare the effect of intravenous lidocaine and dexmedetomidine infusion for preventing CRBD. Methods 120 patients undergoing elective open abdominal hysterectomy and hysteromyoma requiring urinary bladder catheterization were randomly allocated into three groups of 40 each. Group L received a 2 mg/kg lidocaine bolus followed by infusion of 1.5 mg/kg/h; Group D received a 0.5 mg/kg dexmedetomidine bolus followed by infusion of 0.4 mg/kg/h; Group C received a bolus and infusion of normal saline of equivalent volume. The incidence and different severity (mild, moderate, and severe) of CRBD were assessed on arrival in the postanaesthesia care unit at 0, 1, 2, and 6 h postoperatively. Results The incidence of CRBD was significantly lower in Group L and Group D compared with Group C at 0, 1, and 2 h. However, there was no significant difference among the three groups regarding the different severity of CRBD at all time points. The requirement of rescue tramadol for CRBD was lower in group L and group D than in group C. The incidence of sedation was significantly higher in Group D compared to Group L and Group C, though no difference in other adverse effects was observed. Conclusions Intravenous lidocaine and dexmedetomidine infusion reduced the incidence of CRBD as well as the additional tramadol requirement for CRBD, but had no effect on the different severity of CRBD.

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The efficacy of pregabalin for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled double-blind study

Abstract: Pretreatment with pregabalin 150 mg prevents CRBD and also decreases postoperative fentanyl consumption. ClinicalTrials.gov identifier: (ref: CTRI/2013/11/004170).

Cited by 43 publications

References 16 publications

Management of Catheter-Related Bladder Discomfort in Patients Who Underwent Elective Surgery

Management of Catheter-Related Bladder Discomfort in Patients Who Underwent Elective Surgery

Efficacy of trospium for prevention of catheter-related bladder discomfort: a prospective, randomized, placebo-controlled, double-blind study

Comparison of intravenous lidocaine and dexmedetomidine infusion for prevention of postoperative catheter-related bladder discomfort: a randomized controlled trial

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