The efficacy of predatory fungi on the control of gastrointestinal parasites in domestic and wild animals—A systematic review

Canhão-Dias, Miguel; Silva, Adolfo Paz; Carvalho, Luís Madeira de

doi:10.1016/j.vetpar.2020.109173

Cited by 21 publications

(11 citation statements)

References 74 publications

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“…Due to the transmission of strongyles that occurs through the ingestion of third-stage larvae (L3), certain soil saprophytic filamentous fungi capable of forming traps in their mycelium and capturing these mobile stages have been successfully tested. Duddingtonia flagrans, Monacrosporium thaumasium, and Arthrobotrys oligospora are the most frequently used larvicide species in in vivo trials worldwide [9][10][11][12]. Previous investigations showed a significant reduction in the risk of infection by strongyles in sheep given daily chlamydospores of D. flagrans during a period of 8-12 weeks [13,14].…”

Section: Introductionmentioning

confidence: 99%

Control of Strongyles in First-Season Grazing Ewe Lambs by Integrating Deworming and Thrice-Weekly Administration of Parasiticidal Fungal Spores

Voinot

Bonilla²,

Sousa

et al. 2021

Pathogens

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Parasiticidal fungi have been used in several in vivo experiments in livestock farms worldwide, constituting an effective tool for the biocontrol of gastrointestinal parasites in grazing animals. In the first year of study, two groups of eight first-season pasturing ewe lambs infected by strongyles were dewormed with albendazole, and then, the test group received an oral dose of 106 chlamydospores of Mucor circinelloides and 106 Duddingtonia flagrans individually and thrice a week from mid-September to May (FS1), while the control group remained without fungi (CT1). In the second year, two new groups of first-season grazing ewe lambs were treated with ivermectin and subjected to the same experimental design (FS2 and CT2, respectively). The anthelmintic efficacy was 96.6% (CT1), 95.6% (FS1), 96.1% (CT2), and 95.1% (FS2). The counts of strongyle egg output increased in the control groups (CT1 and CT2) throughout the study and reached numbers higher than 600 eggs per gram of feces (EPG), while in FS1 and FS2, they were <250 EPG. The values of red blood cell parameters registered for CT1 and CT2 were lower than those of the reference standards, while a significant increment was recorded in FS1 and FS2, and values within the physiological range were attained. It is concluded that integrating efficient anthelminthic deworming with rotational pasturing and the regular intake of chlamydospores of M. circinelloides and D. flagrans provides a helpful strategy for maintaining low levels of strongyle egg output in first-season grazing ewe lambs and improves their health status.

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Section: Introductionmentioning

confidence: 99%

Control of Strongyles in First-Season Grazing Ewe Lambs by Integrating Deworming and Thrice-Weekly Administration of Parasiticidal Fungal Spores

Voinot

Bonilla²,

Sousa

et al. 2021

Pathogens

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“…Nematophagous fungi, such as Duddingtonia flagrans and Mucor circinelloides , are known to survive passage through the horse gut and to fight strongyle infections and improve horse body condition ( Braga et al, 2009 ; Canhão-Dias et al, 2020 ). The use of D. flagrans as a biological control of cyathostomin nematodes has been successfully tested in plains zebras and African wild ass in a zoological park, and it is now commercially available in the form of inoculated nutritional pellets ( Larsen, 2000 ; Palomero et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

The gastrointestinal nematodes of plains and Grevy's zebras: Phylogenetic relationships and host specificity

Tombak

Hansen

Kinsella³

et al. 2021

International Journal for Parasitology: Parasites and Wildlife

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Equids are chronically infected with parasitic strongyle nematodes. There is a rich literature on horse strongyles, but they are difficult to identify morphologically and genetic studies on strongyles infecting other equid species are few, hampering studies of host specificity. We sequenced expelled worms from two sympatric zebra species in central Kenya to expand the strongyle phylogeny and used DNA metabarcoding on faecal samples to genetically characterize zebra nemabiomes for the first time. We generated sequences for several species new to public genetic reference databases, all of which are typical strongyles in wild zebras (i.e., the three species of Cylindropharynx and Cyathostomum montgomeryi ), and identified their closest relatives. We also discovered an apparent fungus infecting a quarter of the expelled Crossocephalus viviparus worms, a hyperabundant nematode species in the family Atractidae, hinting at the possibility that zebra host-parasite dynamics may involve a zebra-fungus mutualism. The two zebra species had similar nemabiomes; we found a complete overlap in the list of nematode species they carry and very similar prevalence (i.e., proportion of hosts infected) for the different nematode species. Our study suggests limited host-specificity in zebra strongyles and high potential for transmission between the plains zebra and the endangered Grevy's zebra.

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“…For some fungi, such as Po. chlamydosporia and Pa. lilacinus, although good results have been achieved in vitro, few in vivo studies have been performed due to the lack of a reliable approach for administering a standard dose [86]. Differences in the NF trapping efficiency of nematodes are universal among different species of the same genera and different isolated strains of the same species (Tables 1 and 2).…”

Section: Othermentioning

confidence: 99%

Individual and Combined Application of Nematophagous Fungi as Biological Control Agents against Gastrointestinal Nematodes in Domestic Animals

Gong

et al. 2022

Pathogens

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Gastrointestinal nematodes (GINs) are a group of parasites that threaten livestock yields, and the consequent economic losses have led to major concern in the agricultural industry worldwide. The high frequency of anthelmintic resistance amongst GINs has prompted the search for sustainable alternatives. Recently, a substantial number of both in vitro and in vivo experiments have shown that biological controls based on predatory fungi and ovicidal fungi are the most promising alternatives to chemical controls. In this respect, the morphological characteristics of the most representative species of these two large groups of fungi, their nematicidal activity and mechanisms of action against GINs, have been increasingly studied. Given the limitation of the independent use of a single nematophagous fungus (NF), combined applications which combine multiple fungi, or fungi and chemical controls, have become increasingly popular, although these new strategies still have antagonistic effects on the candidates. In this review, we summarize both the advantages and disadvantages of the individual fungi and the combined applications identified to date to minimize recurring infections or to disrupt the life cycle of GINs. The need to discover novel and high-efficiency nematicidal isolates and the application of our understanding to the appropriate selection of associated applications are discussed.

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The efficacy of predatory fungi on the control of gastrointestinal parasites in domestic and wild animals—A systematic review

Cited by 21 publications

References 74 publications

Control of Strongyles in First-Season Grazing Ewe Lambs by Integrating Deworming and Thrice-Weekly Administration of Parasiticidal Fungal Spores

Control of Strongyles in First-Season Grazing Ewe Lambs by Integrating Deworming and Thrice-Weekly Administration of Parasiticidal Fungal Spores

The gastrointestinal nematodes of plains and Grevy's zebras: Phylogenetic relationships and host specificity

Individual and Combined Application of Nematophagous Fungi as Biological Control Agents against Gastrointestinal Nematodes in Domestic Animals

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