The efficacy of platelet-rich fibrin as a scaffold in regenerative endodontic treatment: a retrospective controlled cohort study

Abstract

BackgroundBlood Clot (BC) or platelet concentrates have been used as scaffold in regenerative endodontic treatment (RET). The aim of this retrospective study was to compare the performance of platelet-rich fibrin (PRF) with BC in inducing root development and periapical lesion healing after tooth revascularization.MethodsFive patients receiving RET using PRF as a scaffold were matched 1:1 to a previous cohort of 5 patients who underwent tooth revascularization by provoking periapical bleeding. Clinical signs and symptoms were examined at follow-ups. Periapical lesion healing and root development were monitored radiographically. The resolution of clinical signs and symptoms as well as periapical radiolucency was observed in all patients (100%).ResultsRoot elongation, dentinal wall thickening and apex closure were found in most cases (80% in both groups). There was no significant difference between the groups in terms of clinical sign resolution, root development and periapical healing.ConclusionsWithin the limits of this study, PRF achieved comparable outcomes to BC in terms of clinical sign and symptom resolution, periapical lesion healing and continued root development in RET.

Does the Etiology of Pulp Necrosis Affect Regenerative Endodontic Treatment Outcomes? A Systematic Review and Meta-analyses

“…29 On the other hand, Bezgin et al 25 did not found any significant difference for treatment outcomes between PRP and BC groups. In a randomized controlled study investigating the efficacy of PRF in RET cases, Ragab et al 39 reported that PRF might help to improve 36 consistently found no significant difference between PRF and BC groups in terms of clinical and radiographical outcomes. Ulusoy et al 38 compared RET protocols using PRP, PRF, platelet pellet, and BC and reported that all treatment groups had similar radiographic outcomes regarding the assessment of all root dimensions.…”

“…Eight of them were excluded with reasons shown in the systematic flow chart (Figure 1). The general information and the study characteristics of the 18 included studies [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] are shown in detail in Table 2.…”

Injectable Biomaterials for Dental Tissue Regeneration

“…PRF is considered as an appropriate scaffold material and a promising tool for regenerative endodontics due to its ability to control differentiation of stem cells and deliver growth factors in sustained and controlled manner. Platelet rich plasma (PRP)/PRF combined with collagen membranes was used extensively for periodontal ligament and alveolar bone regeneration as guided tissue in periodontics and oral surgery [174].…”

Platelet-Rich Fibrin Used as a Scaffold in Pulp Regeneration: Case Series

“…2,9 However, there is a limited number of cases in the literature in which PRF is used as a tissue scaffold. 9,11,[14][15][16][17][18] The purpose of this case series is to present the long-term follow-up of regenerative endodontic treatments using PRF tissue scaffold in four necrotic immature permanent teeth.…”