The efficacy of ozone therapy in experimental caustic esophageal burn

Güven, Ahmet; Gündoğdu, Gökhan; Sadir, Serdar; Topal, Turgut; Erdoğan, Esra; Korkmaz, Ahmet; Surer, Ilhami; Öztürk, Haluk

doi:10.1016/j.jpedsurg.2008.01.064

Cited by 54 publications

(49 citation statements)

References 32 publications

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“…The latter suggests that the anti-fibrotic and anti-apoptotic effects of OLM administration in esophageal caustic burn observed in our study could be also attributed to the suppression of oxidative stress by AT1R antagonism. This hypothesis is in agreement with the results of previous studies which demonstrated partially successful treatment of caustic esophageal burns by increasing the antioxidant capacity of the tissue [25][26][27][28][29][30][31][32][33][34][35]. The present study provides new evidence that the renin-angiotensin system can be a promising target for the treatment of esophageal burns caused by corrosive agents.…”

Section: Discussionsupporting

confidence: 93%

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Dereli

Krazinski

Ayvaz

et al. 2014

Folia Histochem Cytobiol.

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Accidentally ingested corrosive substances can cause functional and structural damage to the esophageal tissue resulting in stricture formation. It has been reported that the administration of olmesartan (OLM) can have anti-inflammatory, antifibrotic and antiapoptotic effects on injured tissue. The aim of our study was to check if OLM could prevent formation of scars in the corrosive esophageal burn model. Fifty-one Wistar Albino rats were divided into six groups: Control, Sham, OLM, Sham + OLM, Burn, and Burn + OLM. Olmesartan (5 mg/kg) was given by gavage once per day for 21 consecutive days after injury. The morphology of the esophagus was assessed after Masson trichrome staining, and apoptosis was evaluated using the terminal deoxynucleotidyl transferased UTP nick end labeling (TUNEL) method. The serum nucleosomes (as an indicator of apoptosis), serum p53 protein, and esophageal tissue p53 protein levels of each group were measured by immunoassays. Muscularis mucosa damage, submucosal collagen deposition, and tunica muscularis injury in the Burn + OLM group decreased significantly compared with the Burn group (p < 0.05). Similarly, the number of apoptotic cells in the Burn + OLM group decreased compared with the Burn group (p < 0.05). Serum levels of nucleosomes and p53 and tissue of p53 protein did not differ between the groups. Exogenously administered OLM can effectively prevent the occurrence of esophageal strictures caused by corrosive esophageal burns.

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Section: Discussionsupporting

confidence: 93%

A novel approach for preventing esophageal stricture formation: olmesartan prevented apoptosis

Dereli

Krazinski

Ayvaz

et al. 2014

Folia Histochem Cytobiol.

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“…In addition, generated H 2 O 2 during ozone therapy acts only as a second messenger and it goes to normal or previous levels immediately. 10,21 We found that tissue SOD and GSH-Px enzyme activities were decreased in untreated rats, whereas they were increased in rats receiving ozone therapy. Furthermore, tissue MDA level (indices of tissue damage) was found to be significantly increased in the untreated group and decreased in the treatment group.…”

Section: Discussionmentioning

confidence: 85%

“…H 2 O 2 , an essential ROS molecule, is able to act as an ozone messenger for eliciting several biological and therapeutic effects. 7,8,10,21 The dogma that H 2 O 2 is always harmful has been changed because, in physiological amounts, it behaves as a regulator of signal transduction and is an important mediator of host defense and immune responses. 9,21 While H 2 O 2 acts immediately and disappears (early and short-acting messenger), LOPs, via the circulation, distribute throughout the tissues and become late and long-lasting messengers.…”

Section: Discussionmentioning

confidence: 99%

“…It was demonstrated that ozone increases antioxidant enzyme activities such as glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase, preparing the host to face physiopathologic conditions mediated by reactive oxygen species (ROS), [7][8][9] as reported in our previous works. 7,10 Clinically important beneficial effects of ozone therapy in some disorders such as peritonitis, infected wounds, skin ulcers, and gangrenes have been reported. 8,9 In this study we hypothesized that the ozone therapy may have protective effects in rats with APAP-induced nephrotoxicity by improving antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

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Effects of medical ozone therapy on acetaminophen-induced nephrotoxicity in rats

et al. 2010

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Acetaminophen (APAP), also known as paracetamol, is the commonest cause of toxic ingestion in the world. Because overdose of APAP has life-threatening effects on kidney, treatment of APAP-induced nephrotoxicity has life-saving importance. Aim of the study was to evaluate the efficacy of medical ozone therapy in experimental model of APAP toxication. Twenty-one male Wistar rats (200-250 g) were randomly assigned into three groups containing seven rats each: Sham, control (only APAP treated), and APAP + ozone therapy groups. Rats were killed 48 hours after administration of APAP. Urea, creatinine levels in the blood, and malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) activity in renal tissue were measured. Kidney tissues were stained with hematoxylin and eosin for histological assessment. APAP administration deteriorated the renal functions and significantly elevated renal MDA levels and depleted SOD and GSH-Px activities. Ozone therapy significantly reduced the MDA level, increased the SOD and GSHPx activities, and normalized the renal histology. In conclusion, our study results are consistent with encouraging data for ozone therapy on APAP-induced nephrotoxicity in rats by improving antioxidant mechanism and oxidative stress.

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“…The increase in antioxidant enzyme levels may prevent damage of IR to normal tissues and reduce the inflammation (6). Ozone therapy has beneficial effects in various diseases, such as caustic oesophageal burn, diabetic foot, and radiationinduced cystitis (21)(22)(23). It can be applied by topical, rectal, peritoneal (animal studies), or oral (ozonised water or oil) routes.…”

Section: Discussionmentioning

confidence: 99%