The Efficacy of Non-Pharmacological Interventions on Brain-Derived Neurotrophic Factor in Schizophrenia: A Systematic Review and Meta-Analysis

Sanada, Kenji; Zorrilla, Iñaki; Iwata, Yusuke; Bermúdez-Ampudia, Cristina; Graff‐Guerrero, Ariel; Martínez‐Cengotitabengoa, Mónica; González‐Pinto, Ana

doi:10.3390/ijms17101766

Cited by 28 publications

(18 citation statements)

References 76 publications

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“…One region that has been implicated is the hippocampus [87] although a meta-analysis of four studies did not support this hypothesis [44]. This review [69] also found inconsistent evidence for an effect of exercise on BDNF levels, which is consistent with a meta-analysis [72] (AMSTAR 10, evidence level -1) also finding that exercise did not influence BDNF levels. Thus, whilst there seems reasonable evidence that exercise does improve cognition in schizophrenia-spectrum disorders [67], the underlying mechanisms are not yet clear.…”

Section: Schizophrenia-spectrum Disordersmentioning

confidence: 57%

“…1). Overall, 20 systematic reviews and meta-analyses were included in this guidelines document, which included studies that provided effect sizes for the benefit of exercise for SMI [51] (N = 1), schizophreniaspectrum disorders [67][68][69][70][71][72][73] (N = 7), BD [74,75](N = 2) and MDD [76][77][78][79][80][81][82][83][84][85] (N = 10).…”

Section: Search Results and Included Studiesmentioning

confidence: 99%

“…In total, 7 systematic reviews and meta-analyses reported the benefits of exercise for schizophrenia-spectrum disorders [67][68][69][70][71][72][73]. There was broad variation in the frequency, intensity, type and time of the interventions across the included systematic reviews and meta-analyses ( Table 3).…”

Section: Schizophrenia-spectrum Disordersmentioning

confidence: 99%

See 2 more Smart Citations

EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Psychiatric Association (EPA), supported by the International Organization of Physical Therapists in Mental Health (IOPTMH)

et al. 2018

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Physical activity (PA) may be therapeutic for people with severe mental illness (SMI) who generally have low PA and experience numerous life style-related medical complications. We conducted a meta-review of PA interventions and their impact on health outcomes for people with SMI, including schizophrenia-spectrum disorders, major depressive disorder (MDD) and bipolar disorder. We searched major electronic databases until January 2018 for systematic reviews with/without meta-analysis that investigated PA for any SMI. We rated the quality of studies with the AMSTAR tool, grading the quality of evidence, and identifying gaps, future research needs and clinical practice recommendations. For MDD, consistent evidence indicated that PA can improve depressive symptoms versus control conditions, with effects comparable to those of antidepressants and psychotherapy. PA can also improve cardiorespiratory fitness and quality of life in people with MDD, although the impact on physical health outcomes was limited. There were no differences in adverse events versus control conditions. For MDD, larger effect sizes were seen when PA was delivered at moderate-vigorous intensity and supervised by an exercise specialist. For schizophrenia-spectrum disorders, evidence indicates that aerobic PA can reduce psychiatric symptoms, improves cognition and various subdomains, cardiorespiratory fitness, whilst evidence for the impact on anthropometric measures was inconsistent. There was a paucity of studies investigating PA in bipolar disorder, precluding any definitive recommendations. No cost effectiveness analyses in any SMI condition were identified. We make multiple recommendations to fill existing research gaps and increase the use of PA in routine clinical care aimed at improving psychiatric and medical outcomes.

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Section: Schizophrenia-spectrum Disordersmentioning

confidence: 57%

Section: Search Results and Included Studiesmentioning

confidence: 99%

See 1 more Smart Citation

EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Psychiatric Association (EPA), supported by the International Organization of Physical Therapists in Mental Health (IOPTMH)

et al. 2018

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“…Similarly, a recent study with cyclists detected acute BDNF release during exercise and showed that intensified training improved the athletes' mood state, however, without modifying their plasma BDNF levels (Piacentini et al, ). The time latency for serum BDNF changes in response to behavioral and cognitive interventions is not clear‐cut and probably varies according to the health condition of the individual and the type of therapy (Hakansson et al, ; Kobayashi et al, ; Sanada et al, ; Turakitwanakan, Mekseepralard, & Busarakumtragul, ; Yamada, Yoshimura, Nakajima, & Nagata, ).…”

Section: Discussionmentioning

confidence: 99%

Mindfulness‐based program for stress reduction in infertile women: Randomized controlled trial

et al. 2018

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Infertile women often experience chronic stress, which may have a negative impact on general well‐being and may increase the burden of infertility. In this open‐label, parallel, randomized controlled trial, infertile women aged 18–50 years (median 37 years) were assigned to an 8‐week mindfulness‐based program (MBP) or no intervention. The primary outcome was stress severity measured by the Lipp's Stress Symptoms Inventory (ISSL). Data were analyzed by modified intent‐to‐treat principle, which included all cases available to follow‐up regardless of adherence to the intervention (62 participants from the MBP group and 37 from the control group). The median number of symptoms of chronic stress recorded in the past month decreased from six (interquartile range 2 to 9) before the MBP to two (interquartile range 1 to 4) after the intervention (p < 0.001, repeated measures analysis of variance with Time × Group interaction). Depressive symptoms also decreased after MBP, whereas general well‐being improved (p < 0.01 for both outcomes). Hair cortisol and serum brain‐derived neurotrophic factor (BDNF) did not change significantly between preintervention and postintervention. None of the outcomes changed significantly in the control group. MBP was effective in reducing stress and depressive symptoms while increasing general well‐being in infertile women.

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“…Thus, circulating BDNF has been proposed as a potential biomarker for neuro-psychiatric disorders and neurodegenerative diseases [22,23,24,25,26,27]. On the contrary, the relationship between circulating BDNF and cardiometabolic disorders is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Association between Obesity and Circulating Brain-Derived Neurotrophic Factor (BDNF) Levels: Systematic Review of Literature and Meta-Analysis

Sandrini

Minno

Amadio

et al. 2018

IJMS

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Reduction in brain-derived neurotrophic factor (BDNF) expression in the brain as well as mutations in BDNF gene and/or of its receptor are associated to obesity in both human and animal models. However, the association between circulating levels of BDNF and obesity is still not defined. To answer this question, we performed a meta-analysis carrying out a systematic search in electronic databases. Ten studies (307 obese patients and 236 controls) were included in the analysis. Our data show that obese patients have levels of BDNF similar to those of controls (SMD: 0.01, 95% CI: −0.28, 0.30, p = 0.94). The lack of difference was further confirmed both in studies in which BDNF levels were assessed in serum (MD: −0.93 ng/mL, 95% CI: −3.34, 1.48, p = 0.45) and in plasma (MD: 0.15 ng/mL, 95% CI: −0.09, 0.39, p = 0.23). Data evaluation has shown that some bias might affect BDNF measurements (e.g., subject recruitment, procedures of sampling, handling, and storage), leading to a difficult interpretation of the results. Standardization of the procedures is still needed to reach strong, affordable, and reliable conclusions.

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The Efficacy of Non-Pharmacological Interventions on Brain-Derived Neurotrophic Factor in Schizophrenia: A Systematic Review and Meta-Analysis

Cited by 28 publications

References 76 publications

EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Psychiatric Association (EPA), supported by the International Organization of Physical Therapists in Mental Health (IOPTMH)

EPA guidance on physical activity as a treatment for severe mental illness: a meta-review of the evidence and Position Statement from the European Psychiatric Association (EPA), supported by the International Organization of Physical Therapists in Mental Health (IOPTMH)

Mindfulness‐based program for stress reduction in infertile women: Randomized controlled trial

Association between Obesity and Circulating Brain-Derived Neurotrophic Factor (BDNF) Levels: Systematic Review of Literature and Meta-Analysis

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