The Efficacy of Nano Silver Sulfadiazine and Nano Benzalkonium Chloride on Heterotrophic Biofilms

Türetgen, Irfan; Vatansever, Cansu

doi:10.1134/s0026261719010089

Cited by 5 publications

(7 citation statements)

References 17 publications

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“…This outcome is in accordance with another study in which bacterial biofilm was evaluated; the study showed that the classical culture method and microscopic results could differ. 23…”

Section: Discussionmentioning

confidence: 99%

“…This outcome is in accordance with another study in which bacterial biofilm was evaluated; the study showed that the classical culture method and microscopic results could differ. 23 Regarding surface roughness characteristics, the microstructure of the surface is as important as the intrinsic physicochemical properties of the materials. 24 For the purposes of the present research, the surface roughness values of the…”

Section: S480mentioning

confidence: 99%

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Effect of surface sealant on surface roughness and bacterial adhesion of bulk-fill composites

Ozan

Eren

Vatansever

et al. 2021

Polymers and Polymer Composites

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Surface sealants are reported to ensure surface smoothness and improve the surface quality of composite restorations. These sealants should also reduce the bacterial adhesion on composite surfaces however, there is not much information regarding their performance on bulk-fill composite materials. The aim of this study was to evaluate the effect of surface sealant application on surface roughness and bacterial adhesion of various restorative materials. Disc-shaped samples were prepared from a compomer, a conventional composite and three bulk-fill composites. Specimens of each group were divided into two groups (n = 9): with/without surface sealant (Biscover LV, [BLV]). Surface roughness values were examined by profilometry and two samples of each group were examined for bacterial adhesion on a confocal laser scanning microscope (CLSM). Bacterial counts were calculated by both broth cultivation and microscopic images. Results were analyzed with one-way ANOVA and Bonferroni/Dunn tests. Following the BLV application, there was a decrease in the surface roughness values of all groups however, only Tetric N-Ceram Bulk and Beautifil-Bulk groups showed significantly smoother surfaces (p < 0.001). There were no significant differences among material groups without BLV application. Evaluating bacterial adhesion after BLV application, conventional composite had the lowest values among all followed by the compomer group. Beautifil-Bulk had significantly the highest bacterial adhesion (p < 0.05), followed by Tetric N-Ceram Bulk group. Without BLV application, there was no significant difference among bacterial adhesion values of groups (p > 0.05). CLSM images showed cell viability in groups. Bulk-fill composites showed higher bacterial adhesion than conventional composite and compomer materials. The surface sealant was found to be highly effective in lowering bacterial adhesion, but not so superior in smoothing the surfaces of restorative materials. So, surface sealants could be used on the restorations of patients with high caries risk.

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“…This outcome is in accordance with another study in which bacterial biofilm was evaluated; the study showed that the classical culture method and microscopic results could differ. 23…”

Section: Discussionmentioning

confidence: 99%

Section: S480mentioning

confidence: 99%

Effect of surface sealant on surface roughness and bacterial adhesion of bulk-fill composites

Ozan

Eren

Vatansever

et al. 2021

Polymers and Polymer Composites

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“… 41 , 50 BAC is an intrinsically safe material which is frequently used as a cosmetic ingredient, biocide, germicide, preservative, hand sanitizer, antiseptic, and disinfectant agent. 51 , 52 It has been widely used as a stabilizing surfactant of metal NPs aiming at developing a synergistic antibacterial compound. 53 BAC is listed as antibacterial and novel antituberculosis agent by the Johns Hopkins Clinical Compound Library (JHCCL).…”

Section: Introductionmentioning

confidence: 99%

“…In this regard, previously, Sui et al studied the effect of CTAB on Ag NPs: the differences between SAXS and TEM results explained the CTAB-NPs interaction; they explored the thickness of CTAB shell layers around NPs . Similarly, sodium dodecyl sulfate (SDS), hexadecyltrimethylammonium chloride (CTAC), and hexadecylpyridinium chloride (CPC) surfactants were used to synthesize a AgCl colloidal suspension in aqueous medium and opened the way to the possible use of BAC to prepare AgCl colloids. , BAC is an intrinsically safe material which is frequently used as a cosmetic ingredient, biocide, germicide, preservative, hand sanitizer, antiseptic, and disinfectant agent. , It has been widely used as a stabilizing surfactant of metal NPs aiming at developing a synergistic antibacterial compound . BAC is listed as antibacterial and novel antituberculosis agent by the Johns Hopkins Clinical Compound Library (JHCCL) .…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis and Characterization of Antimicrobial Synergistic AgCl/BAC Nanocolloids

Hossain

Sportelli

Picca

et al. 2022

ACS Appl. Bio Mater.

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All over the world, one of the major challenges is the green synthesis of potential materials against antimicrobial resistance and viruses. This study demonstrates a simple method like chemistry lab titration to synthesize green, facile, scalable, reproducible, and stable synergistic silver chloride/benzyldimethylhexadecyl-ammonium chloride (AgCl/BAC) colloidal Nanoantimicrobials (NAMs). Nanocolloidal dispersions of AgCl in an aqueous medium are prepared by using silver nitrate (AgNO 3 ) as precursor and BAC as both sources of chloride and stabilizer, holding an asymmetric molecular structure. The synthetic approach is scalable and green. Both the morphology and stability of AgCl/BAC nanocolloids (NCs) were investigated as a function of different molar fractions of the reagents. AgCl/BAC NCs were characterized by transmission electron microscopy (TEM) and X-ray photoelectron and UV–vis spectroscopies. Zeta potential measurements revealed increasing positive potential values at every stage of the synthesis. Size distribution and hydrodynamic diameter of the particles were measured by dynamic light scattering (DLS), which predicted the formation of BAC layered structures associated with the AgCl nanoparticles (NPs). Small-angle X-ray scattering (SAXS) experiments verify the thickness of the BAC bilayer around AgCl. The produced AgCl/BAC NCs probably have synergistic antimicrobial properties from the AgCl core and the biocide BAC shell. AgCl/BAC NCs stability over months was investigated. The experimental evidence supports the morphological stability of the AgCl/BAC NCs, while higher positive zeta potential values anticipate a long-term antimicrobial effect: a higher surface charge causes NPs to be potentially more lethal to bacteria. AgCl/BAC antimicrobial aqueous colloidal suspensions will be used as additives for the industrial production of antimicrobial coatings.

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“…Both Bactisure and TorrenTX have benzalkonium chloride acting as a surfactant and antimicrobial agent and ethanol 10% w / v acting principally as a solvent phase polarity modifier, but it may also have an antimicrobial effect under prolonged incubation as occurred during MIC, MEC, MBIC, and MBEC determinations. Benzalkonium chloride is one of the commonly used antiseptics reported in earlier studies [ 33 , 34 ]. The difference is that Bactisure has acetic acid and TorrenTX has citric acid as pH modifiers and chelating agents.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Surgical/Wound Washes against Bacteria: Effect of Different In Vitro Models

et al. 2022

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Topical antiseptics are often used to treat chronic wounds with biofilm infections and during salvage of biofilm contaminated implants, but their antibacterial efficacy is frequently only tested against non-aggregated planktonic or free-swimming organisms. This study evaluated the antibacterial and antibiofilm efficacy of four commercial surgical washes Bactisure, TorrenTX, minimally invasive lavage (MIS), and Betadine against six bacterial species: Staphylococcus epidermidis, Staphylococcus aureus, Streptococcus pyogenes, Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli, which are commonly isolated from surgical site infections and chronic wound infections using different in vitro models. We determined minimum planktonic inhibitory and eradication concentration and minimum 1-day-old biofilm inhibition and eradication concentration of antiseptics in 96-well plates format with 24 h contact time. We also tested the efficacy of antiseptics at in-use concentration and contact time in the presence of biological soil against 3-day-old biofilm grown on coupons with shear in a bioreactor, such that the results are more applicable to the clinical biofilm situations. In the 96-well plate model, the minimum concentration required to inhibit or kill planktonic and biofilm bacteria was lower for Bactisure and TorrenTX than for MIS and Betadine. However, Betadine and Bactisure showed better antibiofilm efficacy than TorrenTX and MIS in the 3-day-old biofilm bioreactor model at in-use concentration. The minimal concentration of surgical washes required to inhibit or kill planktonic bacterial cells and biofilms varies, suggesting the need for the development and use of biofilm-based assays to assess antimicrobial therapies, such as topical antiseptics and their effective concentrations. The antibiofilm efficacy of surgical washes against different bacterial species also varies, highlighting the importance of testing against various bacterial species to achieve a thorough understanding of their efficacy.

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The Efficacy of Nano Silver Sulfadiazine and Nano Benzalkonium Chloride on Heterotrophic Biofilms

Cited by 5 publications

References 17 publications

Effect of surface sealant on surface roughness and bacterial adhesion of bulk-fill composites

Effect of surface sealant on surface roughness and bacterial adhesion of bulk-fill composites

Green Synthesis and Characterization of Antimicrobial Synergistic AgCl/BAC Nanocolloids

Efficacy of Surgical/Wound Washes against Bacteria: Effect of Different In Vitro Models

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