The efficacy of ivermectin, pyrantel and fenbendazole against Parascaris equorum infection in foals on farms in Australia

Armstrong, S. K.; Woodgate, Robert; Gough, Sarah; Heller, Jane; Sangster, Nicholas C.; Hughes, Kristopher

doi:10.1016/j.vetpar.2014.08.028

Cited by 68 publications

(74 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…infection in foals in Saudi Arabia (53%). The recorded prevalence is within the range (31%-61%) reported in previous studies from North America (Austin et al 1990;Lyons et al 2008), Europe (Lind & Cristensson 2009;Laugier et al 2012) and Australia (Armstrong et al 2014) which confirm the common incidence of Parascaris spp. in foals.…”

Section: Discussionsupporting

confidence: 85%

“…However, reduced IVM efficacy against Parascaris spp. has been reported from different parts of the world including North America (Lyons et al 2006;Slocombe et al 2007), Europe (Boersema et al 2002;Lind & Christensson 2009;Veronesi et al 2009;N€ areaho et al 2011;Laugier et al 2012), Brazil (Molento et al 2008), Australia and New Zealand (Armstrong et al 2014;Bishop et al 2014;Beasley et al 2015). Intensive use of MLs such as IVM appears to be associated with development of resistance in Parascaris spp.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, Parascaris spp. resistant to FBZ has been reported in horses from Australia (Armstrong et al 2014). FBZ resistance was possibly selected by intensive use in some horse farms for prevention of gastrointestinal parasites infections.…”

Section: Discussionmentioning

confidence: 99%

“…In the last decade, Parascaris spp. resistant to different groups of anthelmintics has been reported in horses in many countries such as the Netherlands (Boersema et al 2002), USA (Craig et al 2007), UK (Stoneham & Coles 2006), Canada (Hearn & Peregrine 2003;Slocombe et al 2007), Germany (von SamsonHimmelstjerna et al 2007), Sweden (Lindgren et al 2008), Italy (Veronesi et al 2010), France (Geurden et al 2013) and Australia (Armstrong et al 2014). Since chemical treatment is still the mainstay of parasite control measures, the detection of anthelmintic resistance in strongyles has become a critical necessity (Pook et al 2002;Wolstenholme et al 2004).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia

Alanazi

Mukbel

Alyousif

et al. 2017

Veterinary Quarterly

View full text Add to dashboard Cite

Background: In the last decade, Parascaris spp. resistance to anthelmintics has been recorded in many countries. In Saudi Arabia, there are limited data available on Parascaris spp. resistance to anthelmintics. Objective: To determine the current status of ivermectin, abamectin and praziquantel combined, and fenbendazole resistance to Parascaris spp. in horses in Saudi Arabia. Methods: Three hundred and forty-one foals from eleven different farms were examined by faecal egg count (FEC). The foals were all Arab horses aged 17.2 § 4.5 (SD) months. Ivermectin (n = 46 foals), abamectin and praziquantel combined (n = 46), and fenbendazole (n = 46) were administered on day 0 and faeces were collected on day 14. The study comprised 41 untreated foals as controls. Animals that have FEC of 100 eggs per gram (EPG) were used to measure anthelmintic efficacy. Parascaris spp. populations were considered susceptible when faecal egg count reduction (FECR) was 95% associated with a lower 95% confidence limit (LCL) >90%, suspected resistant when FECR 90% or LCL <90% and resistant when FECR <90% and LCL <90%. Results: Prevalence of Parascaris spp. infection was 53% (179/341 horses). Anthelmintic resistance to Parascaris spp. were highest following fenbendazole (55% of farms and 65% of foals) and to a lower extent following ivermectin or the combination of abamectin and praziquantel which comprised 27% of farms (and 46% of foals) and 18% of farms (and 10% of foals), respectively. Conclusion: These data indicate that anthelmintics-resistant Parascaris spp. populations are present on horse farms in Saudi Arabia.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia

Alanazi

Mukbel

Alyousif

et al. 2017

Veterinary Quarterly

View full text Add to dashboard Cite

show abstract

“…Resistance against ivermectin has been described on several occasions in P equorum populations (Table 3) (Peregrine and others 2014) and, at the time of writing, resistance to pyrantel in this species has been reported in the USA (Matthews 2014, Peregrine and others 2014). An Australian study has described benzimidazole-resistant P equorum and also multiple drug resistance on individual yards (Armstrong and others 2014). Benzimidazole-resistant P equorum populations have not been described in the UK but there have been anecdotal reports of reduced efficacy of fenbendazole on UK stud farms.…”

Section: Anthelmintic Resistancementioning

confidence: 99%

Anthelmintic resistance in equine helminths and mitigating its effects

Tzelos¹,

Matthews²

2016

In Practice

View full text Add to dashboard Cite

Helminth control in horses has been based on the administration of broad-spectrum anthelmintics for over 50 years, but although this has reduced clinical disease, anthelmintic-resistant populations of nematodes (for example, cyathostomins and Parascaris equorum) have developed due to frequent ‘blanket’ treatments. Resistance to benzimidazole, pyrantel and, more recently, macrocyclic lactones is not uncommon so strategies that balance the use of anthelmintics for parasite control with the need to limit selection pressure for resistance should be adopted. An inability to control burdens of these nematodes could cause serious health problems, particularly in younger horses, as well as in the small number of individuals that have a higher susceptibility to high levels of infection throughout life. This article reviews anthelmintic resistance in equine nematodes and the measures that can be taken in practice to try to mitigate its spread.

show abstract

Diseases of the Small Intestine

Archer

2017

The Equine Acute Abdomen

View full text Add to dashboard Cite

The efficacy of ivermectin, pyrantel and fenbendazole against Parascaris equorum infection in foals on farms in Australia

Cited by 68 publications

References 28 publications

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia

A field study on the anthelmintic resistance of Parascaris spp. in Arab foals in the Riyadh region, Saudi Arabia

Anthelmintic resistance in equine helminths and mitigating its effects

Diseases of the Small Intestine

Contact Info

Product

Resources

About