The Efficacy of Intravenous Contrast-enhanced 16-raw Multidetector CT Colonography for Detecting Patients With Colorectal Polyps in an Asymptomatic Population in Korea

Kim, Young Sun; Kim, Nayoung; Kim, Se Hyung; Park, Min Jung; Lim, Seon Hee; Yim, Jeong Yoon; Cho, Kyung Ran; Kim, Sun Sin; Kim, Dong Hee; Eun, Hyo Won; Cho, Kyoung Soo; Kim, Jeong Hoon; Choi, Byung Inhn; Jung, Hyun Chae; Song, In Sung; Shin, Chan Soo; Cho, Sang Heon; Oh, Byung Hee

doi:10.1097/mcg.0b013e31811edcb7

Cited by 31 publications

(35 citation statements)

References 24 publications

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“…We included five studies with in total 4,086 patients (54% male). Four studies [26–28, 30, 31] did have a study population of over 200 average risk subjects, the largest population comprised 2,249 average risk subjects [27]. The smallest study had a population of 68 participants at average risk [29].…”

Section: Resultsmentioning

confidence: 99%

Diagnostic value of CT-colonography as compared to colonoscopy in an asymptomatic screening population: a meta-analysis

Haan

Gelder

Graser³

et al. 2011

Eur Radiol

128

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ObjectivesPrevious meta-analyses on CT-colonography included both average and high risk individuals, which may overestimate the diagnostic value in screening. A meta-analysis was performed to obtain the value of CT-colonography for screening.MethodsA search was performed using PubMed, Embase and Cochrane. Article selection and critical appraisal was done by two reviewers. Inclusion criteria: prospective, randomized trials or cohort studies comparing CT-colonography with colonoscopy (≥50 participants), ≥95% average risk participants ≥50 years. Study characteristics and 2 × 2 contingency Tables were recorded. Sensitivity and specificity estimates were calculated per patient and per polyp (≥6 mm, ≥10 mm), using univariate and bivariate analyses.ResultsFive of 1,021 studies identified were included, including 4,086 participants (<1% high risk). I2-values showed substantial heterogeneity, especially for 6–9 mm polyps and adenomas: 68.1% vs. 78.6% (sensitivity per patient). Estimated sensitivities for patients with polyps or adenomas ≥ 6 mm were 75.9% and 82.9%, corresponding specificities 94.6% and 91.4%. Estimated sensitivities for patients with polyps or adenomas ≥ 10 mm were 83.3% and 87.9%, corresponding specificities 98.7% and 97.6%. Estimated sensitivities per polyp for advanced adenomas ≥ 6 mm and ≥ 10 mm were 83.9% and 83.8%.ConclusionCompared to colonoscopy, CT-colonography has a high sensitivity for adenomas ≥ 10 mm. For (advanced) adenomas ≥ 6 mm sensitivity is somewhat lower.

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Section: Resultsmentioning

confidence: 99%

Diagnostic value of CT-colonography as compared to colonoscopy in an asymptomatic screening population: a meta-analysis

Haan

Gelder

Graser³

et al. 2011

Eur Radiol

128

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“…We included 47 prospective studies involving 10,546 patients that compared CTC to the reference standard of CC or surgery [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63]. Table 2 shows detailed information from individual studies.…”

Section: Resultsmentioning

confidence: 99%

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

et al. 2009

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Background: The real accuracy of computed tomographic colonography (CTC) is still unknown. Objective: To perform a meta-analysis of the diagnostic accuracy of CTC for the detection of polyps and colorectal tumors. Methods: Selection of studies:Studiesassessing the accuracy of CTC for the detection of colorectal polyps and tumors were selected. Data synthesis:Meta-analyses combining sensitivities, specificities and likelihood ratios (LRs) for the diagnosis of polyps and colorectal tumors were carried out. Results: Forty-seven studies, providing data of 10,546 patients, were included. Overall per-polyp sensitivity of CTC was 66% (64–68%), for polyps 6–9 mm in size it was 59% (56–61%), and 76% (73–79%) for polyps larger than 9 mm. Overall per-patient sensitivity was 69% (66–72%), for polyps 6–9 mm 60% (56–65%), and 83% (70–85%) for lesions larger than 9 mm. Overall CTC specificity was 83% (81–84%). Positive and negative LRs were 2.9 (1.8–4) and 0.38 (0.27–0.53), respectively; for polyps 6–9 mm in size, they were 3.8 (2.5–5.7) and 0.4 (0.27–0.59), and 12.3 (7.7–19.4) and 0.19 (0.12–0.3) for polyps larger than 9 mm. Conclusion: CTC is highly specific for the detection of colorectal polyps and tumors. Some studies reported high sensitivities, but the results of the studies were highly heterogeneous, while the studied variables explained only part of this discrepancy.

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“…The trial was registered in the Dutch trial register (trial NTR1829; www .trialregister.nl). C omputed tomographic (CT) colonography is an accurate technique for the detection of advanced neoplasia (colorectal cancer and advanced adenomas), the target lesion in colorectal cancer screening (1)(2)(3)(4)(5). Revised colorectal screening guidelines recommend that screening with CT colonography be performed every 5 years, and other guidelines have indicated that CT colonography is a promising screening technique (6)(7)(8).…”

Section: Patients and Settingsmentioning

confidence: 99%

Comparing the Diagnostic Yields of Technologists and Radiologists in an Invitational Colorectal Cancer Screening Program Performed with CT Colonography

Haan¹,

Nio²,

Thomeer³

et al. 2012

Radiology

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The Efficacy of Intravenous Contrast-enhanced 16-raw Multidetector CT Colonography for Detecting Patients With Colorectal Polyps in an Asymptomatic Population in Korea

Abstract: Screening by CTC with asymptomatic population was not promising in Korea despite using advanced CT technology (16-row detector). Bowel preparation was one of the key determinants of the specificity of CTC.

Cited by 31 publications

References 24 publications

Diagnostic value of CT-colonography as compared to colonoscopy in an asymptomatic screening population: a meta-analysis

Diagnostic value of CT-colonography as compared to colonoscopy in an asymptomatic screening population: a meta-analysis

Accuracy of Computed Tomographic Colonography for the Detection of Polyps and Colorectal Tumors: A Systematic Review and Meta-Analysis

Comparing the Diagnostic Yields of Technologists and Radiologists in an Invitational Colorectal Cancer Screening Program Performed with CT Colonography

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