The efficacy of hyperbaric oxygen therapy in the treatment of radiation-induced late side effects

Bui, Quoc-Chuong; Lieber, M; Withers, H. Rodney; Corson, K; Rijnsoever, Marius van; Elsaleh, Hany

doi:10.1016/j.ijrobp.2004.04.019

Cited by 90 publications

(55 citation statements)

References 37 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found significant improvements in patients with stroke following HBOT, and it can lead to neurological improvements even at late chronic stages (11). Gennady G. Rogatsky et al demonstrated the efficacy of HBOT in neurologic status of acute ischemic stroke (35).…”

Section: Strokementioning

confidence: 59%

See 1 more Smart Citation

Hyperbaric Oxygen Therapy and Quality of Life: A Systematic Review

Nourmohammadi

Doaee

Fazel

et al. 2017

Ann Mil Health Sci Res

View full text Add to dashboard Cite

Objective: Hyperbaric oxygen therapy (HBOT) involves breathing pure oxygen in a high-pressure chamber. HBOT is a wellestablished treatment for several diseases, such as serious infections, chronic diabetic foot ulcer, radiation injury, and hidradenitis suppurativa. There are various troublesome diseases that decrease pleasure in life in patients. HBOT has excellent effects in improving QOL in patients with acute and chronic diseases. The present study aimed at assessing the researches that focus on improving the QOL after HBO treatments. Methods:A systematic quest was conducted to evaluate English papers (clinical trials) that were published before April 2017. We searched PubMed, institute of scientific information (ISI), SCOPUS, Web of Science, Ovid, Science direct, ProQuest, Wiley, Cochran, Ebsco host, and Google Scholar. The reference lists of all the articles and electronic journals were searched for further studies. The JAMA users guide evaluation scales for RCTs was used to assess quality of the researched articles. Inclusion and exclusion criteria were extracted according to the scientific criteria. Sample size was 806 patients.Results: Finally, 15 published articles were extracted. Most researches were done in UK (26.7%), Israel (20%), and Sweden (20%). The mean age in HBOT group was 41.88, with a male to female ratio of 1.52. The mean age in the control group was 38.29, with a male to female ratio of 2.14. The most frequent clinical trials were those on the treatment of diabetic foot ulcer (20%), post-concussion syndrome (13.3%), pelvic radiotherapy (13.3%), and chronic arm lymphedema after radiotherapy (13.3%). The most QOL questionnaires used were SF-36 (21.4%), EORTC (European organization for research and treatment of cancer) QLQ-C30, head and neck cancer module (H&N35), and performance status scale (PSS).Conclusions: A significant effect of HBOT on improving QOL in patients' outcomes and symptoms was found compared with the control group. We found improved QOL in patients with diabetic foot ulcer, post-concussion syndrome, pelvic radiotherapy, post stroke, hidradenitis suppurativa, tonsillar fossa tumor radiotherapy, jaw osteonecrosis, and fibromyalgia syndrome. We suggest that HBOT be added to conventional treatment of these patients as an adjuvant.

show abstract

Section: Strokementioning

confidence: 59%

“…Hyperbaric oxygen therapy cures radiation soft tissue necrosis, cystitis, and proctitis (11). There are various troublesome diseases that affect QOL in patients.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric Oxygen Therapy and Quality of Life: A Systematic Review

Nourmohammadi

Doaee

Fazel

et al. 2017

Ann Mil Health Sci Res

View full text Add to dashboard Cite

show abstract

“…Approximately 80% of the cases required surgical management 15) . Moreover, some reports agreed that HBO was effective on only minor ORNJ 16) . Our data also showed no obvious shortening of the healing term for ORNJ (Table 7).…”

Section: Discussionmentioning

confidence: 98%

“…In addition, in 2004 the European Committee for Hyperbaric Medicine (ECHM) strongly recommended HBO for the treatment of patients with radionecrosis of the mandible 14) . However, while the effectiveness of HBO on ORNJ has been reported, there have been reports which questioned that effect 15,16) . As a result, the effectiveness of HBO on ORNJ thus remains controversial 17) .…”

Section: Introductionmentioning

confidence: 99%

The Influence of Radiation Therapy and Hyperbaric Oxygen Therapy on Osteoradionecrosis of the Jaw

Ohba¹,

Yoshimura²,

Kobayashi³

et al. 2013

J. Hard Tissue Biology.

View full text Add to dashboard Cite

The object of this study was to estimate the influence of radiation therapy (RT) and hyperbaric oxygen therapy (HBO) on osteoradionecrosis of the jaw (ORNJ). This retrospective study included patients who were diagnosed with ORNJ from 1998 to 2012 (15 years) and who recieved a total dose of RT (Gy) for the duration of the study. The duration of ORNJ development and the healing period of ORNJ were examined. The mean dose of RT was 64.0 Gy. The mean healing period of ORNJ was 30.3 months in the continuous RT group, and 20.8 months in the pre-and post-operative irradiation group. The healing term for ORNJ with HBO was approximately the same as that without HBO. We concluded continuous RT may induce more severe ORNJ than pre-and postoperative RT, and that the effectiveness of HBO on ORNJ is suspicious.

show abstract

“…In a small placebo controlled prospective trial, Carl et al reported significant improvements in pain and swelling in 44 patients with late radiation induced injury post-radiotherapy for breast cancer [4]. In another retrospective trial of 75 patients with osteoradionecrosis, 81% of patients responded to HBOT [12]. The Consensus Conference, led by the European Society for Therapeutic Radiology and Oncology and the European Committee for Hyperbaric Medicine, recommended prospective collection of toxicity data and setting up of multi-centre randomized controlled trials to obtain higher levels of evidence for indications of HBOT [11].…”

Section: Discussionmentioning

confidence: 99%

A randomised prospective study of extended tocopherol and pentoxifylline therapy, in addition to carbogen, in the treatment of radiation late effects

Brennan¹,

Salib²,

O'Shea³

et al. 2008

ecancer

View full text Add to dashboard Cite

Purpose: pentoxifylline (PTX) and tocopherol (vitamin E) are antioxidants previously shown to be useful in combination in the treatment of late radiation induced toxicity. The purpose of this study was to investigate the benefit of combination therapy with carbogen pentoxifylline and tocopherol in the mitigation of late radiation effects. As the optimal duration of PTX and tocopherol treatment has not been fully established, we studied short versus extended treatment duration.Methods: we conducted a phase II prospective randomized study of short versus prolonged treatment with pentoxifylline (800 mg) and tocopherol (1000 IU) orally once daily in patients with grade three toxicity post-radical radiotherapy. In addition, all 18 patients received inhaled carbogen (95% O + 5% CO 2 ) over 90 minutes, five days/week, for three weeks. The primary end point was improved in maximum Lent-Soma toxicity scores.Results: maximum Lent-Soma scores improved in six of the 18 patients (response rate 33%). The proportion of patients responding to treatment in the prolonged treatment arm B was more than double than in the shorter arm A, but this did not reach statistical significance (p=0.321). Two patients who had prolonged treatment (arm B) had complete resolution of their symptoms, which was maintained at two and three year follow-ups.Conclusions: we recommend prolonged treatment for 12 months, with PTX and tocopherol in combination with carbogen therapy, in the management of late radiation effects.

show abstract

The efficacy of hyperbaric oxygen therapy in the treatment of radiation-induced late side effects

Cited by 90 publications

References 37 publications

Hyperbaric Oxygen Therapy and Quality of Life: A Systematic Review

Hyperbaric Oxygen Therapy and Quality of Life: A Systematic Review

The Influence of Radiation Therapy and Hyperbaric Oxygen Therapy on Osteoradionecrosis of the Jaw

A randomised prospective study of extended tocopherol and pentoxifylline therapy, in addition to carbogen, in the treatment of radiation late effects

Contact Info

Product

Resources

About