The efficacy of ginger root in the prevention of postoperative nausea and vomiting after outpatient gynaecological laparoscopy

Visalyaputra, Shusee; Petchpaisit, N.; Somcharoen, Kanchana; Choavaratana, Roungsin

doi:10.1046/j.1365-2044.1998.00369.x

Cited by 75 publications

(61 citation statements)

References 19 publications

(19 reference statements)

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“…nih.gov), EMBASE (http://stneasy.fiz-karlsruhe.de) und dem Cochrane controlled trials register (http://www.cochrane.de) durchgeführt. Anhand der Begriffe «ginger OR ingwer», «ginger AND nausea», «ginger AND vomiting» wurde systematisch nach randomisierten klinischen Studien zum Thema [8,[10][11][12][13], in einer weiteren Studie Laparotomien und vaginale Hysterektomien untersucht [9]. In zwei dieser Untersuchungen [9,11] [10].…”

Section: Materials Und Methodenunclassified

“…Die Kommission E des damaligen Bundesgesundheitsamtes publizierte daraufhin eine Positivmonographie für die Indikationsgebiete «Dyspeptische Beschwerden» sowie «Verhinderung der Symptome der Reisekrankheit» [7]. Klinische Studien wurden darüber hinaus auch zum Thema Übelkeit und Erbrechen in der postoperativen Phase (PONV = postoperative nausea and vomiting) [8][9][10][11][12][13] sowie zum Thema Schwangerschaftsübelkeit bzw. Hyperemesis gravidarum durchgeführt [14][15][16][17].…”

Section: Introductionunclassified

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Ist Ingwer ein klinisch relevantes Antiemetikum? Eine systematische Übersicht randomisierter kontrollierter Studien

Betz

Kranke²,

Geldner³

et al. 2005

Complement Med Res

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Background and Objective: The aim of this systematic review was to evaluate the clinical impact of ginger (Zingiber officinale) as an antiemetic. Methods: A systematic search of the literature was performed using the databases of MEDLINE, EMBASE, and the Cochrane-Library. Results: Of 100 published reports discerned as potentially relevant, 24 randomized controlled trials were evaluated, covering 1073 patients which had received ginger. Of these reports, 16 contained information regarding the antiemetic activity of the phytotherapeutic agent against kinetosis, postoperative nausea and vomiting (PONV), and morning sickness and hyperemesis gravidarum, respectively. Only a few studies were eligible for a quantitative analysis (meta-analysis). Thus, the majority of the reports were analyzed descriptively. To analyze the potential side effects of the drug, 15 reports with 777 patients were eligible. Of these, 3.3% suffered from slight side effects, mainly mild gastrointestinal symptoms and sleepiness, both not requiring specific treatments. One severe adverse event was reported in a study: an abortion occurred in the 12th week of gestation. However, a total of 136 patients were treated with ginger within the first trimenon of pregnancy without complications. Conclusion: There is no clear evidence for the efficacy of ginger in the treatment of PONV and of kinetosis. The results for the treatment of nausea and vomiting in pregnancy are encouraging, however, ginger should be applied for the time being only in controlled clinical studies. Applied in daily doses up to 6 g ginger seems to be a drug with few side effects.

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Section: Materials Und Methodenunclassified

Section: Introductionunclassified

Ist Ingwer ein klinisch relevantes Antiemetikum? Eine systematische Übersicht randomisierter kontrollierter Studien

Betz

Kranke²,

Geldner³

et al. 2005

Complement Med Res

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show abstract

“…18,19 The powdered rhizome of Z officinale has long been used as a herbal remedy for gastrointestinal disorders such as nausea, vomiting, dyspepsia, constipation, flatulence, and colic. 18,19 Modern scientific research has also confirmed that ginger might be effective against nausea and vomiting induced by motion sickness, sea sickness, surgery, and pregnancy. [20][21][22][23][24][25] With respect to CINV, there is evidence on the efficacy of ginger in animals.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting

et al. 2012

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Nausea and vomiting are among the most prevalent and disturbing side effects of chemotherapy.1,2 These side effects may lead to several adverse impacts in patients receiving chemotherapeutic agents, such as decreased quality of life, anxiety, depression, and lack of compliance to the medication.2,3 Chemotherapy-induced nausea and vomiting (CINV) is classified into 3 types: acute CINV, which occurs during the first 24 hours postchemotherapy; delayed CINV, which begins after24 hours postchemotherapy and may last for up to 6 or 7 days; and finally anticipatory CINV, which affects people who have experienced severe nausea and vomiting in their previous administrations of chemotherapeutic agents. AbstractBackground. Nausea and vomiting are among the most prevalent and disturbing side effects of chemotherapy. Therefore, there is a need for additional antiemetic agents that could effectively reduce chemotherapy-induced nausea and vomiting (CINV), whether alone or in combination with current standard therapies. Since clinical data on the effectiveness of ginger in patients with advanced breast cancer is lacking, the present study aimed to evaluate the effects of ginger against both acute and delayed forms of CINV in a population with advanced breast cancer as the main malignancy. Methods. In this pilot, randomized, open-label clinical trial, 100 women (mean age = 51.83 ± 9.18 years) with advanced breast cancer who were initially assigned to standard chemotherapy protocol with docetaxel, epirubicin, and cyclophosphamide (the TEC regimen) were randomized to receive ginger (1.5 g/d in 3 divided doses every 8 hours) plus standard antiemetic regimen (granisetron plus dexamethasone; the ginger group) or standard antiemetic regimen alone (control group). The duration of treatment with ginger was specified to 4 days from the initiation of chemotherapy. Prevalence, score, and severity of nausea, vomiting, and retching were assessed using a simplified form of Rhodes index in the first 6 hours, between 6 to 24 hours, and days 2, 3, and 4 postchemotherapy. Results. A significantly lower prevalence of nausea was observed in the ginger group during 6 to 24 hours postchemotherapy. Despite this effect, no other significant additional benefit from ginger (1.5 g/d) was observed against prevalence or severity of nausea, vomiting, and retching in any of the assessed periods. Conclusion. Addition of ginger (1.5 g/d) to standard antiemetic therapy (granisetron plus dexamethasone) in patients with advanced breast cancer effectively reduces the prevalence of nausea 6 to 24 hours postchemotherapy. However, there is no other additional advantage for ginger in reducing prevalence or severity of acute or delayed CINV.

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“…Drei Studien zeigten ein negatives Ergebnis [11,13,21], drei weitere ein positives [9,10,14]! Morin et al [22] poolten die Daten dieser sechs Studien und kamen zu dem Ergebnis, dass für Ingwer zur Behandlung von postoperativer Nausea keine Signifikanz vorhanden ist.…”

Section: Klinische Studien 2000-2009unclassified

Ingwer: Gewürz und Arzneipflanze - wenig bekannte und unterschätzte therapeutische Eigenschaften

Bachmann¹

2016

Schweiz Z Ganzheitsmed

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The efficacy of ginger root in the prevention of postoperative nausea and vomiting after outpatient gynaecological laparoscopy

Cited by 75 publications

References 19 publications

Ist Ingwer ein klinisch relevantes Antiemetikum? Eine systematische Übersicht randomisierter kontrollierter Studien

Ist Ingwer ein klinisch relevantes Antiemetikum? Eine systematische Übersicht randomisierter kontrollierter Studien

Effect of Ginger on Acute and Delayed Chemotherapy-Induced Nausea and Vomiting

Ingwer: Gewürz und Arzneipflanze - wenig bekannte und unterschätzte therapeutische Eigenschaften

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