The efficacy of fibrin sealant in knee surgery: A meta-analysis

Yang, Ti-min; Geng, Xilin; Ding, M.C.; Yang, Minghan; Zhang, Q.

doi:10.1016/j.otsr.2014.07.035

Cited by 13 publications

(11 citation statements)

References 27 publications

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“…Therefore, we used changes in Hb levels after 24 to 48 hours as a tool to determine the effect of hemostasis. Several studies have reported that the use of FS in orthopedic knee surgery was effective in reducing vascular bleeding and the need for routine blood transfusion [10,11]. FS reduced the complications related to blood transfusions and decreased the costs related to the transfusions and acute postoperative bleeding control.…”

Section: Discussionmentioning

confidence: 99%

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Will a Fibrin Sealant be Effective as a Seroma Reductant and a Hemostatic Agent in Breast Reconstruction Using a Latissimus Dorsi Flap?

Lee

Kang

Tak

2017

Arch Aesthetic Plast Surg

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BackgroundThe latissimus dorsi (LD) flap is widely used in breast cancer reconstruction, but donor-site morbidity is one of the major limitations of this surgery. Donor-site seroma is the most common complication. To prevent seroma formation, we consider the use of a fibrin sealant (FS) because of its hemostatic and sealing effects. In this study, we investigate the effect of a FS on seroma prevention and as a hemostatic agent at the LD donor site. Methods A retrospective study was conducted from 2011 to 2015. Herein, we analyzed the preoperative status, changes in the hemoglobin (Hb) level according to the postoperative day, postoperative drain amount, and the drain removal time. Results The decline in the Hb level was not statistically significantly less in the FS group than in the control group. Further, the difference in the drain amount between the 2 groups was not statistically significant either. The seroma rate and the drain removal time between the 2 groups also did not show any statistically significant difference. Conclusions The FS does not have hemostatic effect and the drain amount reduction in the early phase of recovery and does not prevent seroma. Therefore, an empirical use of the FS alone is no longer recommended to prevent seroma. In contrast, the quilting suture has been reported to be effective in seroma prevention. Therefore, it is necessary to study the effects of a combination of quilting sutures and the FS on seroma and the other risk factors of this surgical complication.

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Section: Discussionmentioning

confidence: 99%

“…Several studies reporting that the use of FS in knee surgery was effective in reducing vascular bleeding and routine blood transfusions have been published [10,11]. However, thus far, no study on the hemostatic effect of FS on the donor-site morbidity of LD flaps has been reported.…”

Section: Introductionmentioning

confidence: 99%

Will a Fibrin Sealant be Effective as a Seroma Reductant and a Hemostatic Agent in Breast Reconstruction Using a Latissimus Dorsi Flap?

Lee

Kang

Tak

2017

Arch Aesthetic Plast Surg

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“…Blood loss control and prevention strategies include the use of pneumatic tourniquets, hypotensive anesthesia, blood transfusions, and pharmacological agents; the latter, however, may be related to complications inherent to their use. 5 6…”

Section: Introductionmentioning

confidence: 99%

“…As estratégias de controle e de prevenção da perda sanguínea incluem o uso de torniquetes pneumáticos, anestesia hipotensiva, hemotransfusões e agentes farmacológicos, sendo que estes últimos podem se relacionar a complicações inerentes ao seu uso. 5 6…”

Section: Introductionunclassified

Estudo prospectivo sobre o impacto do uso do selante de fibrina humano livre de agentes estabilizadores de coágulo na artroplastia total de joelho

et al. 2019

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Resumo Objetivo O objetivo do presente estudo foi avaliar os resultados do uso tópico intraoperatório do selante de fibrina humano livre de agentes estabilizadores de coágulo em pacientes com osteoartrite (OA) submetidos a artroplastia total de joelho (ATJ), buscando diferenças entre os grupos em relação à perda sanguínea, à necessidade transfusional, ao tempo de internação hospitalar, à percepção de dor, à amplitude de movimento e à incidência de complicações. Métodos Foram analisados prospectivamente um grupo de intervenção (Selante) com 32 pacientes e um grupo controle (Controle) com 31 pacientes, com OA sintomática dos joelhos, submetidos a ATJ. Resultados Os resultados foram semelhantes entre os grupos, em relação à perda sanguínea visível no dreno em 24 horas (Controle 276,5 mL ± 46,24 versus Selante 365,9 mL ± 45,73), à perda sanguínea total em 24 horas (Controle 930 mL ± 78 versus Selante 890 mL ± 67) e em 60 horas de pós-operatório (Controle 1.250 mL ± 120 versus Selante 1.190 mL ± 96), à necessidade de hemotransfusão (ocorreu em apenas 1 controle), ao tempo de dias na permanência hospitalar (Controle 5,61 ± 0,50 [n = 31] versus Selante 4,81 ± 0,36), dor pós-operatória e amplitude de movimento. O uso do agente selante de fibrina não se relacionou à ocorrência de complicações da cicatrização de ferida, de infecção ou de trombose venosa profunda. Conclusão Concluímos que o agente hemostático de fibrina humana não foi eficaz em reduzir o volume de sangramento e a necessidade de hemotransfusão ou em interferir no tempo de internação hospitalar, na percepção de dor e na amplitude de movimento. Seu uso não se relacionou a nenhuma complicação.

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“…Some approaches to reduce the bleeding during orthopedic surgery, such as the use of fibrin sealant and/or tranexamic acid, have been used. 12,13 A clear understanding of the fibrinolytic dysregulation in these patients will help to develop adequate approaches to control bleeding. It has been reported that controlling the blood loss during surgery contributes to shorter hospital stay.…”

Section: Introductionmentioning

confidence: 99%