The efficacy of fesoterodine in patients after transurethral resection of the  prostate

Kuzmenko, A V; Kuzmenko, V V; Gyaurgiev, T A

doi:10.18565/urology.2019.1.52-55

Cited by 3 publications

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“…Метод имеет наибольшую доказательную базу относительно эффективности в восстановлении оттока мочи из мочевого пузыря вследствие простатической инфравезикальной обструкции [16]. Однако, несмотря на свои достоинства, данная операция сопровождается достаточно высокой частотой осложнений, из которых наиболее опасные для здоровья пациента -кровотечение (2,9 %), тампонада мочевого пузыря (4,9 %), инфекционно-воспалительные заболевания (4,1 %), стриктура уретры (5-7 %), склероз шейки мочевого пузыря (2-4 %) [17][18][19][20].…”

Section: Introductionunclassified

Evaluation of the effectiveness of personalized complex therapy in patients with benign prostatic hyperplasia and chronic prostatitis

Barannikov

Kuzmenko

Gyaurgiev

et al. 2021

Urology reports (St. - Petersburg)

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PURPOSE OF THE STUDY: to evaluate the effectiveness of personalized complex treatment of patients with benign prostatic hyperplasia (BPH) in combination with chronic prostatitis using a combined physiotherapeutic effect, taking into account the individual chronobiological characteristics of patients. MATERIALS AND METHODS: We examined 60 patients with benign prostatic hyperplasia and chronic prostatitis who were sent to the TUR of the prostate. Patients were divided into two groups (n = 30). The comparison group (CG) was treated with alpha-blockers and fluoroquinolones for 28 days. In the main group (MG) personalized complex therapy. The effectiveness of treatment was evaluated at the time of treatment (visit 1), two weeks later (visit 2) and 4 weeks later (visit 3). The severity of lower urinary tract symptoms, prostate volume and residual urine volume, hemodynamic parameters in the gland were evaluated, and a bacterioscopic and bacteriological examination of prostate secretion was performed. RESULTS: At the end of 4 weeks of therapy, statistically significant differences (p 0.05) were found in the MG for all the studied parameters. In the bacteriological study of prostate secretions at visit 1 Escherichia coli prevailed in the crops. At visit 2 to the CG bacteria were detected in 11 (36.7%) crops, and in 10 (33.3%) patients in the MG. At visit 3, no microbial growth was detected in both groups based on the results of a bacteriological examination of prostate secretions. Initially, both groups had low hemodynamic parameters in the prostate. After the treatment, a more pronounced dynamics of improvement of blood flow in the gland by visit 2 was noted in the MG than in the GP. By visit 3, statistically significant differences were found in all the studied indicators (p 0.05). CONCLUSION: Thus, according to the results, a personalized comprehensive treatment of patients with benign prostatic hyperplasia and chronic prostatitis reduced the severity of lower urinary tract symptoms and manifestations of the inflammatory process in the prostate, improved hemodynamic parameters and increase of efficiency of antibacterial therapy, as evidenced by the results of bacteriological studies. PURPOSE OF THE STUDY: to evaluate the effectiveness of personalized complex treatment of patients with benign prostatic hyperplasia (BPH) in combination with chronic prostatitis using a combined physiotherapeutic effect, taking into account the individual chronobiological characteristics of patients. MATERIALS AND METHODS: We examined 60 patients with benign prostatic hyperplasia and chronic prostatitis who were sent to the TUR of the prostate. Patients were divided into two groups (n = 30). The comparison group (CG) was treated with alpha-blockers and fluoroquinolones for 28 days. In the main group (MG) personalized complex therapy. The effectiveness of treatment was evaluated at the time of treatment (visit 1), two weeks later (visit 2) and 4 weeks later (visit 3). The severity of lower urinary tract symptoms, prostate volume and residual urine volume, hemodynamic parameters in the gland were evaluated, and a bacterioscopic and bacteriological examination of prostate secretion was performed. RESULTS: At the end of 4 weeks of therapy, statistically significant differences (p 0.05) were found in the MG for all the studied parameters. In the bacteriological study of prostate secretions at visit 1 Escherichia coli prevailed in the crops. At visit 2 to the CG bacteria were detected in 11 (36.7%) crops, and in 10 (33.3%) patients in the MG. At visit 3, no microbial growth was detected in both groups based on the results of a bacteriological examination of prostate secretions. Initially, both groups had low hemodynamic parameters in the prostate. After the treatment, a more pronounced dynamics of improvement of blood flow in the gland by visit 2 was noted in the MG than in the GP. By visit 3, statistically significant differences were found in all the studied indicators (p 0.05). CONCLUSION: Thus, according to the results, a personalized comprehensive treatment of patients with benign prostatic hyperplasia and chronic prostatitis reduced the severity of lower urinary tract symptoms and manifestations of the inflammatory process in the prostate, improved hemodynamic parameters and increase of efficiency of antibacterial therapy, as evidenced by the results of bacteriological studies.

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Section: Introductionunclassified

Evaluation of the effectiveness of personalized complex therapy in patients with benign prostatic hyperplasia and chronic prostatitis

Barannikov

Kuzmenko

Gyaurgiev

et al. 2021

Urology reports (St. - Petersburg)

View full text Add to dashboard Cite

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“…В течение длительного времени «золотым стандартом» хирургического лечения АП является трансуретральная резекция (ТУР) простаты [1][2][3][9][10][11][12][13][14][15]. Данное вмешательство имеет высокую эффективность, достигающую 80%, но, как и любая хирургическая операция, оно сопровождается рядом осложнений.…”

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“…Наиболее значимыми и распространенными из них являются стриктуры уретры (5-7%), тампонада мочевого пузыря (4,9%), инфекционно-воспалительные заболевания (4,1%), кровотечение (2,9%), склероз шейки мочевого пузыря (2-4%) и др. [9][10][11][12][13][14][15].…”

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Efficacy of personalized combined treatment for preventing postoperative complications in patients with benign prostatic hyperplasia and chronic prostatitis

Barannikov¹,

Kuzmenko²,

Kuzmenko³

et al. 2021

Russian Medical Inquiry

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Aim: to assess the efficacy of personalized combined treatment for preventing postoperative complications after transurethral resection of the prostate (TURP) in patients with benign prostatic hyperplasia (BPH) and chronic prostatitis (CP) that involves complex physiotherapy using “SMART-PROST” device considering individual chronobiological characteristics. Patients and Methods: 60 patients with BPH and CP who were referred for TURP were examined. α-blockers and fluoroquinolones were prescribed for 28 days in the control group (n=30). Personalized complex therapy was additionally prescribed in the study group (n=30). Treatment efficacy was assessed at baseline (visit 1), after two weeks (visit 2), and after four weeks (visit 3). The severity of lower urinary tract symptoms, prostate volume and postvoid residual volume, and prostatic hemodynamics were evaluated. Additionally, expressed prostatic secretion bacterioscopy and culture and TURP specimen histology were performed. Results: significant differences (p<0.05) in all clinical laboratory tests and prostatic hemodynamics were demonstrated between the groups by the end of week 4. Histology of TURP specimens revealed more severe fibrosis and inflammatory infiltration in the control group. During a 6-month follow-up, acute urinary retention was detected in 2 patients (6.7%), leukocytes in the urine in 18 patients (60%), blood in the urine in 5 patients (16.7%), and bacteria in the urine in 14 patients (46.7%) of the control group. Meanwhile, acute urinary retention was detected in 1 patient (3.3%), leukocytes in the urine in 10 patients (33.3%), blood in the urine in 2 patients (6.7%), and bacteria in the urine in 7 patients (23.3%) of the study group. Conclusion: personalized combined therapy for BPH and CP reduced the severity of lower urinary tract symptoms and the signs of prostatic inflammation, improved prostatic hemodynamics, and increased the efficacy of antibacterial therapy as demonstrated by bacteriological tests. KEYWORDS: chronic prostatitis, benign prostatic hyperplasia, TURP, chronotherapy, personalized combined physiotherapy, TRUS, Doppler ultrasound, immunohistochemistry. FOR CITATION: Barannikov I.I., Kuzmenko A.V., Kuzmenko V.V., Gyayrgiev T.A. Efficacy of personalized combined treatment for preventing postoperative complications in patients with benign prostatic hyperplasia and chronic prostatitis. Russian Medical Inquiry. 2021;5(3):110– 117. DOI: 10.32364/2587-6821-2021-5-3-110-117.

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Chronobiological approach to the treatment of patients with benign prostate hyperplasia and chronic prostatitis: results of a morphological examination

Kuzmenko

Владимирович²,

Gyaurgiev

et al. 2021

Urology reports (St. - Petersburg)

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MATERIALS AND METHODS: 60 patients with benign prostatic hyperplasia (BPH) and category II chronic prostatitis (NIH, 1995) were examined. The average age of the patients was 60.55.5 years. The patients were divided into two groups of 30 people each. The comparison group (GC) included patients who received standard therapy with drugs from the group of alpha-blockers and fluoroquinolones. The main group (MG) consisted of patients who received standard therapy in combination with physiotherapy sessions with the device SMART-PROST, which were carried out in the acrophase of the chronorhythm. After the end of the course of therapy all patients underwent transurethral resection of the prostate, after which a morphological and morphometric (immunohistochemical) study of the obtained material was carried out. RESULTS: According to the results of the morphological and morphometric examination of the histological material in patients of the CG and MG, statistically significant differences were revealed in all the studied parameters, which testify to the persistence of signs of the inflammatory process in the CG, while in the MG, the severity of inflammation was significantly lower. CONCLUSION: According to the results of the study, personalized complex therapy of patients with benign prostatic hyperplasia in combination with chronic prostatitis using a combined physiotherapeutic effect of the SMART-PROST device, taking into account the individual chronobiological characteristics of patients, allows to more effectively arrest the inflammatory process in the prostate tissue, which can lead to a decrease in the number of postoperative complications. However, the last statement requires further more detailed study.

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The efficacy of fesoterodine in patients after transurethral resection of the prostate

Cited by 3 publications

References 0 publications

Evaluation of the effectiveness of personalized complex therapy in patients with benign prostatic hyperplasia and chronic prostatitis

Evaluation of the effectiveness of personalized complex therapy in patients with benign prostatic hyperplasia and chronic prostatitis

Efficacy of personalized combined treatment for preventing postoperative complications in patients with benign prostatic hyperplasia and chronic prostatitis

Chronobiological approach to the treatment of patients with benign prostate hyperplasia and chronic prostatitis: results of a morphological examination

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