“…Acupuncture has been shown to regulate bone morphogenetic protein, retinoic acid [84], wnt, nerve growth factor, [85,86] IGF-1 [87,87,88] , platelet derived growth factor [89], atrogin-1, protein kinase Akt1, [70] vascular endothelial growth factor, angiogenesis, [90] increase bone density [91,91,92], neuroplasticity (as in the healing of spinal cord injury) [87], and stem cell proliferation. [93] , [69] Acupuncture showed promise in ameliorating muscle atrophy, [70] osteoporosis [94] , [91] obesity [95], diabetes [96], polycystic ovary syndrome [86], stroke [90], and sepsis [97,98]. The perturbation at singular points of a system can stimulate self-organizing activities and cause a process of normalization by shaking a system out of a suboptimal state similar to simulated annealing.…”