The efficacy of diffusion weighted imaging and apparent diffusion coefficients mapping for liver metastasis of colonic adenocarcinomas

Abstract

Objectives:To establish retrospectively the relation between the histopathologic grade of colorectal liver metastasis and apparent diffusion coefficient (ADC) values of hepatic metastases of colorectal adenocarcinomas.Methods:The diagnoses of liver metastases were confirmed with biopsy, surgery, and follow-up imaging findings. Twenty-six patients with 94 liver metastasis were included in the study. Of 94 masses, 59 were poorly-differentiated adenocarcinoma, 18 were moderately-differentiated adenocarcinoma, and 17 were well-differentiated regarding the diameters, ADC values, and ratio index (RI) values. Kolmogorov-smirnov normality test, Kruskal-wallis analysis of variance, Mann-Whitney U test with Bonferroni correction, Spearman correlation analysis, and receiver operating characteristics curve methods were applied to evaluate the statistical relations.Results:There was a statistically significant difference in terms of ADC values and RI between poorly-differentiated adenocarcinoma and moderately-differentiated adenocarcinoma plus well-differentiated adenocarcinomas. Poorly-differentiated adenocarcinomas have the lowest ADC values and highest RI values among other groups.Conclusion:Use of ADC values alone can be executed for the diagnosis of focal hepatic masses and also can aid in the differentiation of benign and malignant hepatic lesions.

Renal Cell Carcinoma or Oncocytoma? The Contribution of Diffusion-Weighted Magnetic Resonance Imaging to the Differential Diagnosis of Renal Masses

“…The sensitivity and specificity of the ADC at this value was 59.1 and 85.7%, respectively. Taouli B et al [22] concluded that DWI could provide additional information to contrast enhanced studies in the diagnosis of oncocytoma and histologic subtypes of RCC that was consistent with our findings. Anna K. et al [24] stated that they included 26 oncocytomas, 97 ccRCC and 29 pRCC patients, and found a significant statistical difference between the papillary type RRC and clear cell RCC, but they did not find a significant difference between clear cell RCC and oncocytoma.…”

“…Measurable data obtained with DWI could give an idea about the nature of the lesions in various parts of the body and helped to characterize them without using any intravenous contrast agents [21]. Recent research based on the MRI of renal tumors has shown that ADC values obtained by DWI could provide new quantitative data to distinguish benign tumors from malignant ones, and consequently might help to identify pathological subtypes of neoplasms [22,23].…”

Estimation of colon cancer grade and metastatic lymph node involvement using DWI/ADC sequences

“…A non-invasive assessment of tumor grade can be an important stage-independent prognostic variable, and a high grade is associated with poor patient survival (35). Another study conducted by Metin et al (36) investigated the relationship between the histopathologic grade of colorectal adenocarcinomas in liver metastases and ADC values. They showed that poorly differentiated adenocarcinomas have the lowest ADC values among other groups.…”